1,721,044 research outputs found
Nose-to-brain delivery
No full textNose-to-brain delivery represents a big challenge. In fact there is a large number of neurological diseases that require therapies in which the drug must reach the brain, avoiding the difficulties due to the blood–brain barrier (BBB) and the problems connected with systemic administration, such as drug bioavailability and side-effects. For these reasons the development of nasal formulations able to deliver the drug directly into the brain is of increasing importance. This Editorial regards the contributions present in the Special Issue “Nose-to-Brain Delivery”
Tabletted polylactide microspheres prepared by a w/o emulsion-spray drying method
No full textNon disponibil
Spray-dried microspheres for ocular administration of piroxicam: in vitro/in vivo evaluation
No full text
Therapeutic application of intrabodies against age-related neurodegenerative disorders.
No full textMany neurodegenerative diseases, referred to as misfolding diseases, are characterized by the formation and accumulation of pathological extracellular and intracellular misfolded aggregates. Ageing is considered the major risk factor for neurodegenerative disorders and, due to increase of mean lifespan, the clinical relevance is growing dramatically with a urgent need to find new effective therapeutic approaches. The intracellular antibody technology is a gene-based strategy which exploits the specificity of recombinant antibodies to neutralize or modify the function of intracellular and extracellular target antigens. Intrabodies can potentially recognize all the pathological conformers of a misfolding-prone protein, and therefore they are emerging as therapeutic agents for the treatment of misfolding diseases as well as molecular tools for the understanding of their pathogenesis. Here we focus on the application of intrabodies against two major age-related neurodegenerative disorders, Alzheimer's disease (AD) and Parkinson's disease (PD) and the description of in vivo gene delivery systems available for their potential entering in the clinical setting
Supramicellar solutions of sodium dodecyl sulphate as dissolution media to study the in vitro release characteristics of sustained-release formulations containing an insoluble drug: nifedipine
No full textNanotechnology-based rose Bengal: A broad-spectrum biomedical tool
No full textRose Bengal is an anionic xanthene dye, a derivative of fluorescein, born in the 19th century as a textile dye; to date, it is known primarily in ophthalmology as a diagnostic tool and demonstrated to be promising in the biomedical field. Rose Bengal intrinsic cytotoxicity against tumor and microbial cells is responsible for its therapeutic potential; moreover, it is a sono-photosensitizer drug suitable for sono-photodynamic therapy. Due to its disadvantageous bio-pharmaceutical profile, Rose Bengal is approved only as an ocular diagnostic stain and has been designated by the Food and Drug Administration as an orphan drug to treat certain cancers. Two main pharmaceutical approaches such as molecular structural changes and drug delivery systems were investigated to overcome Rose Bengal limits. The current review reports the physical-chemical profile and pharmacokinetic properties of Rose Bengal and presents a short overview of its biomedical applications. The review focuses on Rose Bengal nanosized delivery systems already developed to outline the current research topics and to assess whether nanotechnology can maximize its therapeutic potential overcoming its limits. Through the revision of Rose Bengal research articles about this topic, it emerges that a proper Rose Bengal nanosized delivery system can efficiently improve its biopharmaceutical profile and enhance Rose Bengal-based therapy
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