125,307 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Progetto per componenti automotive
No full textI dati attualmente disponibili ai progettisti sul comportamento meccanico a fatica delle leghe d’alluminio da fonderia sono svariati, ma sfortunatamente, non essendo organizzati in maniera organica, risultano di difficile reperibilità. Da qui è sembrata evidente la necessità di sviluppare un database che raccogliesse e organizzasse, in modo strutturato, le informazioni attualmente disponibili sulle caratteristiche a fatica delle leghe d’alluminio da fonderia. La decisione di implementare questo database proprio su questa tipologia di leghe è accompagnata poi dal loro crescente utilizzo in ambito tecnico e industriale; tali leghe offrono infatti una elevata versatilità, favorendone l’utilizzo in svariati settori. Componenti strutturali realizzati in leghe d’alluminio sono vitali nell’industria aerospaziale, e in altri settori, quali quello dei trasporti e delle costruzioni, nei quali leggerezza, durata e resistenza statico-dinamica sono necessari
Elucidating RAD52 architecture through an integrated structural biology approach
No full textHuman RAD52 (hRAD52) is a 47 kDa protein of 418 amino acids, which plays important functions in many DNA repair mechanisms such as HR and SSA. Recent studies have shown that simultaneous loss of hRAD52 and other DNA repair proteins, such as BRCA1, BRCA2, PALB2, XAB2 or RAD51 paralogs results in synthetic lethal. This evidence highlights hRAD52 as a promising target for drug discover studies aimed at triggering synthetic lethality in BRCA2 deficient cells. hRAD52 consists of two functionally different domains: the highly conserved N-terminal domain (a.a. 1-208), responsible for oligomerization and DNA binding, and the less conserved C-terminal domain (209-418), which contains the nuclear localization signal sequence (NLS), and binding regions for hRAD51 and RPA. Although the interest in hRAD52 has exponentially grown in the last decade, much remains unknown about its structure and mechanism of action. In particular, the absence of structural information for the C-terminal domain of hRAD52 FL hinders a comprehensive understanding of its interactions with partner interactors. To get novel structural insights on this interesting target, Cryo-EM studies were performed on the hRAD52 FL. While the N-terminal region of RAD52 FL is structured in an undecameric ring, as demonstrated by previous X-ray crystallography studies, the C-terminal domain was poorly resolved and largely absent, highlighting that this region is intrinsically disordered. To address the flexibility of the C-terminal domain and gain additional structural insights, we combined AlphaFold2 simulations and SEC-SAXS experiments. These analyses confirmed the extreme flexibility of the RAD52 C-terminal domain, which can be described as an intrinsically disordered region. This observation further draws attention on the role played by this portion of the protein, which may fold only upon partner binding. These results will significantly inform future investigations into RAD52’s mechanism of action and the development of inhibitors, especially within emerging synthetic lethality strategies
Pragmatic Case Studies as a Source of Unity in Applied Psychology
No full textTo unify or not to unify applied psychology: that is the question. In this article we review pendulum swings in the historical efforts to answer this question—from a comprehensive, positivist, “top-down,” deductive yes between the 1930s and the early 60s, to a postmodern no since then. A rationale and proposal for a limited, “bottom-up,” inductive yes in applied psychology is then presented, employing a case-based paradigm that integrates both positivist and postmodern themes and components. This paradigm is labeled “pragmatic psychology” and, its specific use of case studies, the “Pragmatic Case Study Method” (“PCS Method”). We call for the creation of peer-reviewed journal-databases of pragmatic case studies as a foundational source of unifying applied knowledge in our discipline. As one example, the potential of the PCS Method for unifying different angles of theoretical regard is illustrated in an area of applied psychology, psychotherapy, via the case of Mrs. B. The article then turns to the broader historical and epistemological arguments for the unifying nature of the PCS Method in both applied and basic psychology.Peer reviewe
Dr. Edwin Wright Collection: Author Unknown
No full textNotes - The author relates several short stories about his neighbours including Alex McDonell, homesteading and life around Meanook and Athabasca (1 page
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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