1,721,094 research outputs found
Health and economic impact associated with a quadrivalent HPV vaccine in Italy
No full textObjective:
The aim of this study was to determine the health impact and cost-effectiveness of introducing a human papillomavirus (HPV) vaccination programme with a quadrivalent vaccine alongside the existing cervical cancer screening programme in comparison to the current context in Italy.
Methods.
A US Markov model was adapted to the Italian context, assuming under base case 80% vaccine coverage rate, lifetime duration of protection in a cohort of girls aged 12 years and discount rates of 1.5% and 3% for health benefits and costs, respectively, and estimating direct medical costs.
Results.
The HPV vaccination in association with the current screening programme would allow to avoid 1432 cases of cervical cancer (− 63.3%) and 513 deaths (− 63.4%) compared to screening only, with an incremental cost-effectiveness ratio (ICER) of €9569 per additional quality-adjusted life-year (QALY) gained. The sensitivity analysis highlighted that this model was robust to all parameters presenting uncertainties as the ICERs ranged from €2,781 to €48,122 per QALY gained.
Conclusion.
This study showed that HPV vaccination in adolescent girls would be a beneficial and cost-effective public health programme in Italy
Timing of gene expression and oolemma localization of mouse alpha 6 and beta 1 integrin subunits during oogenesis.
No full textRecruitment strategies and interventions to increase participation in lung cancer screening programmes: A systematic review protocol
Full text linkIntroductionDespite strong evidence for the efficacy of low-radiation dose CT (LDCT) in reducing lung cancer (LC) mortality, implementing LC screening (LCS) programmes remains a challenge. We aim to systematically review the evidence on the strategies used to recruit the adult population at risk of LC to LDCT within LCS programmes and to estimate the effectiveness of interventions identified, used to reach the potentially eligible population, increase participation and informed choice, and ensure equitable access.Methods and analysisThis sequential systematic literature review will consist of three steps: (1) a scoping review of existing strategies and organisational models for LCS; (2) selecting papers reporting relevant outcomes (test coverage, screening participation and informed choice) and comparing results among different models; (3) a systematic review of interventions implemented to increase participation in LCS programmes. Each step will follow the methodological guidelines provided by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Data sources include electronic databases such as Medline (PubMed version), Embase, CINAHL (Ebsco version), Scopus and Cochrane CENTRAL. The search will be limited to studies published from January 2000 to March 2023 in English, Italian, French, Spanish, Serbian and Croatian language. Findings will be synthesised quantitatively and qualitatively as appropriate. Risk of bias assessment will be only applied to studies selected in the second and third steps. The quality of evidence will be summarised for each outcome using the Grading Recommendation Assessment, Development and Evaluation methodology.Ethics and disseminationGiven that this is a review of existing literature, ethics approval is not required. The results will be published in peer-reviewed scientific journals and presented at relevant conferences. The findings of this review will help guide health authorities in organising LCS programmes and developing recommendations, policies, and actions at national and regional levels.PROSPERO registration numberCRD42023408357
Corrigendum to “Associations between cervical, breast and colorectal cancer screening uptake, chronic diseases and health-related behaviours: Data from the Italian PASSI nationwide surveillance” (Preventive Medicine (2019) 120 (60–70), (S0091743519300155), (10.1016/j.ypmed.2019.01.007))
No full textThe purpose of this Corrigendum is to correct the authorship masthead of the article to indicate that the PASSI Working Group is the last item in the list, as shown above. This correction was requested by the authors of the paper to allow compliance with rules of authorship set forth by the Italian Ministry of Health. The contents of the article remain unchanged. The authors would like to apologise for any inconvenience caused
Response to: COVID-19 in paediatric rheumatology patients treated with b/tsDMARDs: A cross-sectional patient survey study' by Cuceoglu et al
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