1,721,234 research outputs found
Gastrointestinal stromal tumors treatment in the Imatinib era. The role of fair indication
No full textMinerva Chirurgica 2012 Aprile;67(2):165-73 lingua: Inglese Tumori stromali gastrointestinali nell’era dell’Imatinib. Il ruolo della corretta indicazione Vendettuoli M., Pironi D., Pontone S., Panarese A., La Gioia G., Arcieri S., Romani A. M., Palazzini G., Filippini A. ✉ Department of Surgical Sciences, La Sapienza University, Rome, Italy PDF Obiettivo. I tumori stromali gastrointestinali (gastrointestinal stromal tumors, GIST) rappresentano la più comune causa di tumori mesenchimali dell’apparato digerente. La chirurgia rimane il trattamento di prima scelta. Nel nostro studio abbiamo analizzato i tassi di sopravvivenza e recidiva in due gruppi di pazienti trattati chirurgicamente prima e dopo l’avvento dell’Imatinib. Metodi. Sono stati analizzati due gruppi di pazienti sottoposti a chirurgia per GIST selezionati tra il gennaio del 1997 e il dicembre 2002 (gruppo Pre-IM) e tra il gennaio 2003 e il dicembre 2008 (gruppo Post-IM). Caratteristiche anagrafiche e anamnestiche, manifestazioni cliniche, sede e stadiazione dei tumori sono state registrate e confrontate. Risultati. Nel gruppo Pre-IM il tasso di sopravvivenza media e stato di 24,6 mesi (15-51). I pazienti appartenenti al gruppo Post-IM sono attualmente sotto stretto controllo oncologico (follow-up medio 50,7 mesi; range 26-74) manifestando una ottima risposta alla terapia farmacologica. Conclusioni. La diagnosi precoce e la chirurgia radicale rimangono ad oggi le armi più efficaci nel trattamento dei GIST. Gli ottimi risultati ottenuti con l’utilizzo dell’Imatinib suggeriscono un più ampio utilizzo nel trattamento farmacologico. La nostra esperienza suggerisce un’elevata correlazione tra lo stato mutazionale della proteina KIT e la prognosi clinica. Questo aspetto merita ulteriori approfondimenti in futuri studi randomizzatiMinerva Chir. 2012 Apr;67(2):165-73. Gastrointestinal stromal tumors treatment in the Imatinib era. The role of fair indication. Vendettuoli M1, Pironi D, Pontone S, Panarese A, La Gioia G, Arcieri S, Romani AM, Palazzini G, Filippini A. Author information Abstract AIM: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Surgery remains the elective treatment. We retrospectively compared two group of patients, who underwent surgery for GIST before and after Imatinib advent in order to analyze the recurrence and survival rate. METHODS: Two patient groups who underwent surgery for GIST, from January 1997 to December 2002 (Pre-Imatinib group) and from January 2003 to December 2008 (Post-Imatinib group) were compared. Patients were evaluated on the base of gender, age, clinical manifestations, primary location and metastasis positivity, tumor size, mitotic index, immunoreactivity for CD117 and the outcome, including date of death. RESULTS: In the Pre-IM group only one patient died for prostate cancer, 12 months after operation, the other died because of GIST with a 24.6 months of median survival rate (range 15-51). In the remaining 12 patients the median follow up period was 55 months (range 6-152 months). In the Post-IM group the mean follow up was 50.7 months (range 26-74) and they are still being assessed for oncological as well as surgical treatment. CONCLUSION: Early diagnosis and radical resection remain the standard of cure for GISTs. To date, the use of Imatinib lead to its utilization as adjuvant and neo-adjuvant therapy in adults. Our experience suggests that there is a correlation between the mutational status of KIT and clinical outcome. These aspects should be explored for targeted therapy that can effectively combine biological therapy to surgery. PMID: 22487918 [PubMed - indexed for MEDLIN
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Applicabilità di un modello di valutazione del deflusso superficiale nell’analisi di frequenza delle piene
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Rappresentazione delle precipitazioni in Puglia mediante un modello multifrattale ad impulsi
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La turbolenza nella camera di mescolamento dell’iniettore idraulico indagine sperimentale sulla sua lunghezza.
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