116,405 research outputs found
Estimation of Geomagnetically Induced Currents (GICS) in the Namibian transmission network
No full textIncludes bibliographical references.Geomagnetically Induced Currents (GICs) have become a matter of concern not only to networks located in high magnetic latitude regions but also in networks located in mid-latitude regions. GICs pose a threat of transmission equipment damage which could lead to short power interruptions and potentially long term blackouts. Improved modelling techniques are essential in predicting the GICs flowing in the network in order to enable power utilities to reduce the risk of damage to equipment and improve the reliability of their power supply. This dissertation, entitled ESTIMATION OF GEOMAGNETICALLY INDUCED CURRENTS (GICS) IN THE NAMIBIAN TRANSMISSION NETWORK, aims at improving GIC estimation by installing measurement equipment in order to compare measured GIC results with modelled results. The purpose of which is to validate the calculation technique. The Nodal Admittance technique was proposed for the study and was first validated using published data obtained using the a&b parameter method. For the measurement techniques, two methods were found namely direct measurements in the transformer neutral conductor and indirect measurements in the transmission lines. In this dissertation, the former was implemented due to its simplicity in usage
Tuneable graphite intercalates for hydrogen storage
Get PDFThe development of hydrogen as an energy transfer mechanism is of great
importance to alleviate environmental damage and economic destabilisation
caused by over-reliance on oil, as long as the hydrogen can be generated renewably. To be suitable for road transport applications, safe and compact
hydrogen storage systems need to be developed, the primary technological
motivation for this PhD project which investigates hydrogen absorbed into
graphite intercalation compounds (GICs), to gain a fundamental physical understanding of the sorption processes to improve such materials' capacity for
hydrogen storage. Literature searching has led to a principal investigation,
primarily using neutron scattering and thermogravimetry, of potassium and
calcium-GICs with hydrogen. Inelastic neutron scattering on hydrogenated
KC24 has shown hydrogen sorption in this system to be quantitatively different from its analogues RbC24 and CsC24. A consistent model of the H2 sites
and dynamics has been proposed. Time-resolved structural data on the hydriding phase transition in KC8Hx have been obtained. A calcium-ammonia
intercalate has shown most promise for hydrogen storage, with uptake of 3.2
wt.% H2 at 77 K and 2 bar, a signifcant amount of the 6 wt.% target set by
the US DoE. It is concluded that available internal volume and donor charge
in GICs are critical parameters for optimising hydrogen uptake
Final report and recommendations of the Health Information Exchange Use Case Design Group : report prepared for : the Connecticut Health IT Advisory Council / prepared by Michael Matthews (chief strategy officer), Carol Robinson (chief executive officer)
No full text1 online resource (19 pages)"Contributors: Stacy Beck, Pat Checko, DrPH, Kathy DeMatteo, Gerard Muro, MD, Mark Raymond, Jake Star, Lisa Stump, MS, RPh."; "October 31, 2017."; Includes bibliographical reference
FTH1 knockdown lowers cell viability of T3691 but not T387 GICs following radiation.
No full textGICs were transfected with FTH1 or control siRNA at siRNA (μg): liposome (μl) ratios of 2:4 (T3691) or 2:8 (T387) for 24h, followed by no radiation (0Gy) or radiation at 4Gy and 8Gy. Cell viability was assessed 24 and 48 hours after radiation exposure using MTS assay. (A, B) In T3691 GICs, at both 24h (a) and 48h (b) post radiation, cell viability in FTH1 siRNA treated group was significantly reduced relative to control siRNA irrespective of radiation at 0Gy, 4Gy and 8Gy (*** = p<0.001). FTH1 siRNA treated T3691 cells radiated at 8Gy showed an additive decrease in cell viability relative to un-irradiated controls (0Gy) (Λ = p<0.01) as well as cells radiated at 4Gy (Λ # = p<0.05). However, there was no significant reduction in viability at 4Gy relative to un-irradiated controls (0Gy). (C) 24h post radiation, T387 GICs also showed significant decrease in cell viability at all three doses (*** = p<0.001). (D) T387 GICs showed no decrease in cell viability at 48h post radiation (ns = not significant). T387 GICs showed no significant change in cell viability after radiation exposure relative to un-irradiated controls (ns = not significant). Data from three experiments was normalized to liposome treated controls.</p
The UN-SUSTAINABLE Match in HCV Recipients. Evidences from the Italian D-MELD Study on Balancing Donor-Recipient Risk Factors
No full textThe UN-SUSTAINABLE Match in HCV Recipients. Evidences from the Italian D-MELD Study on Balancing Donor-Recipient Risk Factor
Unlocking the mysteries of the past: Searching for clues in medieval manuscripts
No full textThis project looks at the reproduction of one mid-12th-century Roman text by analyzing sixteen versions of it that still exist, copied from c. 1160 through c. 1325. The author was Nicolaus Maniacutius, a cleric at St. John Lateran Basilica in Rome. That original copy is lost, but versions quickly appeared in monasteries and cathedrals in Italy, Germany, France, and England. Somehow, through networks of communication and travel, reproductions were made and collected by prominent monasteries and churches, and by the Guildhall, a secular institution in the City of London
Global Initiative for Children’s Surgery (GICS) Pediatric Trauma Care Initiative: A Call for a Comprehensive Approach to a Global Problem
Get PDFIntroduction: Trauma is a major problem which has a significant health, social, and economic impact. Particularly, pediatric trauma carries substantial mortality and morbidity. This is a great concern for subspecialized general and pediatric surgeons. Therefore, a global initiative for pediatric trauma care is warranted and should be initiated. Aim: The international association “Global Initiative for Children’s Surgery” (GICS) would like to propose and organize a children’s trauma care (CTC) initiative. This initiative should comprehensively address pediatric trauma management globally, especially in low- and middle-income countries (LMICs). The initiative seeks to achieve a structured cooperation and collaboration with respective sister organizations and local stakeholders. Methods: The initiative will address these relevant aspects: 1. first aid; 2. prehospital primary trauma care; 3. hospital primary trauma care; 4. advanced care (ATLS); 5. diagnostic facilities; 6. operation room (OR) equipment; 7. specialized surgical services; 8. rehabilitation; 9. registry, research, and auditing; 10. specialization in pediatric trauma; 11. capacity and confidence building in pediatric trauma; 12. prevention. The GICS CTC provided activities have been recorded and evaluated in a structured manner. This statement paper is based on data of a narrative review as well as expert opinions. Results: The Trauma Working Group of GICS provided specialized trauma prevention leaflets available for translation to different languages. A one-day children’s primary trauma course has been designed to be delivered at the physical GICS meetings. Exercising advocacy, the group addressed several meetings on prevention of pediatric trauma, which included the 75th United Nations General Assembly (UNGA) (2020), GICS IVth meeting in Johannesburg (2020), Norwich (UK) Joint SPRINT Symposium on Pediatric Surgery for Pediatricians (2021), the second online Pan African Pediatric Surgical Association (PAPSA) meeting (2021), the seventh World Congress of the World Federation of Associations of Pediatric Surgeons (WOFAPS) in Prague (2022), and GICS pediatric trauma webinar (2023). Additionally, the working group participated in the preparations of a pediatric trauma module for the World Health Organization (WHO) and published several related studies. The contents of the selected articles added relevant information to the categories stated above. Conclusions: The CTC initiative of GICS is proposed as a mean to address pediatric trauma comprehensively through a process of collaboration and advocacy with existing organizations to achieve awareness, health education, prevention, health, and training. Further, it will support the provision of suitable facilities to health institutions. The establishment of a specialization in pediatric trauma is encouraged. GICS CTC initiative aims to improve pediatric trauma care in LMICs by developing injury prevention strategies; optimizing the use of locally available resources; obtaining commitment by LMICs governments; improvement in all fields of hospital care; improvements in infrastructure, education and training, and attention to data registry and research
Pulse oximetry adoption and oxygen orders at paediatric admission over 7 years in Kenya: a multihospital retrospective cohort study
Get PDFObjectives To characterise adoption and explore specific clinical and patient factors that might influence pulse oximetry and oxygen use in low-income and middle-income countries (LMICs) over time; to highlight useful considerations for entities working on programmes to improve access to pulse oximetry and oxygen.
Design A multihospital retrospective cohort study.
Settings All admissions (n=132 737) to paediatric wards of 18 purposely selected public hospitals in Kenya that joined a Clinical Information Network (CIN) between March 2014 and December 2020.
Outcomes Pulse oximetry use and oxygen prescription on admission; we performed growth-curve modelling to investigate the association of patient factors with study outcomes over time while adjusting for hospital factors.
Results Overall, pulse oximetry was used in 48.8% (64 722/132 737) of all admission cases. Use rose on average with each month of participation in the CIN (OR: 1.11, 95% CI 1.05 to 1.18) but patterns of adoption were highly variable across hospitals suggesting important factors at hospital level influence use of pulse oximetry. Of those with pulse oximetry measurement, 7% (4510/64 722) had hypoxaemia (SpO2 <90%). Across the same period, 8.6% (11 428/132 737) had oxygen prescribed but in 87%, pulse oximetry was either not done or the hypoxaemia threshold (SpO2 <90%) was not met. Lower chest-wall indrawing and other respiratory symptoms were associated with pulse oximetry use at admission and were also associated with oxygen prescription in the absence of pulse oximetry or hypoxaemia.
Conclusion The adoption of pulse oximetry recommended in international guidelines for assessing children with severe illness has been slow and erratic, reflecting system and organisational weaknesses. Most oxygen orders at admission seem driven by clinical and situational factors other than the presence of hypoxaemia. Programmes aiming to implement pulse oximetry and oxygen systems will likely need a long-term vision to promote adoption, guideline development and adherence and continuously examine impact
Multi-Industry Simplex : A Probabilistic Extension of GICS
Get PDFAccurate industry classification is a critical tool for many asset management
applications. While the current industry gold-standard GICS (Global Industry
Classification Standard) has proven to be reliable and robust in many settings,
it has limitations that cannot be ignored. Fundamentally, GICS is a
single-industry model, in which every firm is assigned to exactly one group -
regardless of how diversified that firm may be. This approach breaks down for
large conglomerates like Amazon, which have risk exposure spread out across
multiple sectors. We attempt to overcome these limitations by developing MIS
(Multi-Industry Simplex), a probabilistic model that can flexibly assign a firm
to as many industries as can be supported by the data. In particular, we
utilize topic modeling, an natural language processing approach that utilizes
business descriptions to extract and identify corresponding industries. Each
identified industry comes with a relevance probability, allowing for high
interpretability and easy auditing, circumventing the black-box nature of
alternative machine learning approaches. We describe this model in detail and
provide two use-cases that are relevant to asset management - thematic
portfolios and nearest neighbor identification. While our approach has
limitations of its own, we demonstrate the viability of probabilistic industry
classification and hope to inspire future research in this field.Comment: 17 pages, 10 figure
Low-cost GICs reduce survival rate in occlusal ART restorations in primary molars after one year: A RCT
No full textIntroduction: The high costs of the worldwide recommended GICs might be a barrier for the implementation of ART. To overcome this problem, low cost GIC are used even though there is a lack of evidence for the survival rate of restorations. Objectives: To evaluate the performance of low-cost GICs used on occlusal ART restorations after one year. Methods: A total of 150 primary molars in 150 children with occlusal caries lesions were selected in 4–8 year-old children. The patients were randomly allocated in three groups: G1–GC Gold Label 9 (GC Corp); G2–Vitro Molar (DFL) and G3–Maxxion R (FGM). All treatments were performed following the ART premises in school setting. Restorations were evaluated after 2, 6 and 12 months. Restoration survival was evaluated using Kaplan-Meier survival analysis and Log-rank test and Cox regression was used for testing association with clinical factors (α = 5%). Results: GC Gold Label 9 had better performance compared to the low-cost GICs (HR = 1.47, CI = 1.04–2.08, p = 0.027). The overall SR of restorations was 65.33% and the SR per group was G1 = 77.55%; G2 = 61.11% and G3 = 42.55%. Conclusions: The low-cost GICs have a poorer performance than GC Gold Label 9 in occlusal ART restoration in primary molars
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