169,963 research outputs found
Testing for anti-glycolipid IgM antibodies in chronic immune-mediated demyelinating neuropathies
No full textAntibodies to several nerve antigens have been reported in patients with chronic immune-mediated demyelinating neuropathies including chronic inflammatory demyelinating polyradiculoneuropathy, multifocal motor neuropathy, and IgM paraproteinemic demyelinating polyneuropathy. The association of some reactivities with specific neuropathies, such as IgM antibodies to the myelin-associated glycoprotein in neuropathy associated with IgM monoclonal gammopathy, permitted to cast some light in their pathogenetic mechanisms and introduced new useful tools in their diagnosis. Other antibodies have been variably associated with other forms of neuropathy or with neuropathy itself, casting some doubts on their diagnostic relevance in the workout of these neuropathies. This is particularly true for IgM antibodies to glycolipids, including ganglioside and sulfatides, whose possible role in immune-mediated neuropathies is still debated and will be here reviewed
Increased sensitivity of anti-GM1-galactocerebroside complex IgM antibodies in the diagnosis of multifocal motor neuropathy
No full textAnti-ganglioside complex IgM antibodies in multifocal motor neuropathy and chronic immune-mediated neuropathies.
No full textAnti-ganglioside complexes (GSCs) IgG antibodies have been reported in patients with Guillain-Barré (GBS) or Fisher syndrome but little is known on their presence in multifocal motor neuropathy (MMN) or other chronic immune-mediated neuropathies. We examined 24 patients with MMN, 34 with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), 23 with neuropathy associated with IgM monoclonal gammopathy (PN+IgM), 13 with GBS, 34 with motor neuron disease (MND), 24 with other neuropathies and 20 normal subjects. Patients' sera were tested by ELISA for IgM reactivity to GM1, GM2, GD1a, GD1b and GT1b and with GSCs made by any combination of two of these gangliosides. In all GM1 positive patients with MMN (11), PN+IgM (1), CIDP (1) and POEMS (1), binding to GM1 was abolished or consistently reduced when tested in GSCs also containing GD1a or other gangliosides. This only occurred in one of the three GM1 positive MND patients. In a patient with PN-IgM and anti-GM2 and GD1a IgM, both reactivities were reduced when tested in GSCs also containing GM1. New reactivities were found in a patient with CIDP and anti-GD1b IgM who presented an additional reactivity to GT1b/GM1 and GT1b/GM2 GSCs, and in one with PN-IgM who had reactivity to GM2/GD1b but not to individual gangliosides. Testing for IgM antibodies to GSCs rarely permitted to identify new reactivities in chronic immune neuropathies. IgM binding to gangliosides was however often modified in GSCs suggesting that these reactivities may be affected by contiguous gangliosides possibly influencing their pathogenicity
Medieval Islamic type pottery from Siponto (Italy): an integrated physical-chemical and mineralogical investigation
No full textPhysical–chemical and morpho-mineralogical characterizations were performed on siliceous paste
fragments from the archaeological site at Siponto (Foggia, Italy). Analytical investigations, by optical
and scanning electron microscopy, powder x-ray diffraction, x-ray fluorescence and atomic spectroscopy,
were carried out on ceramic bodies, coatings and decorations in order to outline the technological features
and define the nature of coatings and pigments. The fragments, characterized by a siliceous paste bulk,
true stonepaste type,with alkali–lime or lead–alkali glaze, sometimes coloured by Cu andMn compounds
and decorated by incision, recall the ceramic production technologies typical of the Egyptian and the
Syrian–Palestinian areas. The discovery of these fragments and the results of the investigations carried
out prove the existence of extensive cultural exchanges between Apulia and the Middle East during the
Middle Ages. This research provides extremely valuable input for the evaluation of the historical and
artistic evolution of the relationship between different cultures, highlighting the relevance of scientific
investigations also in archaeological fields other than provenance and dating
Studio comparativo tra un rivestimento in idrossiapatite ed uno in vetro bioattivo delle fasi iniziali della crescita ossea
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