1,721,062 research outputs found
Uncovering an IL-10-dependent NF-{kappa}B recruitment to the IL-1ra promoter that is impaired in STAT3 functionally defective patients
No full textThe interleukin 1 receptor antagonist (IL-1ra) is an important negative regulator of the inflammatory response, whose genetic deficiency has been recently shown to cause a severe autoinflammatory syndrome in humans. In this study we characterized the molecular mechanisms whereby interleukin 10 (IL-10) potentiates IL-1ra transcription in LPS-stimulated monocytes and neutrophils. Using chromatin immunoprecipitation, we show that although NF-kappaBp65 and NF-kappaBp50 proteins accumulate into the nuclei and bind to the IkappaBalpha promoter during LPS stimulation, they are not recruited to the kappaB sites of the IL-1ra promoter. However, in response to LPS plus IL-10, which were found to induce chromatin acetylation, recruitment of both NF-kappaBp65 and NF-kappaBp50 to the IL-1ra promoter efficiently occurs in a STAT3-dependent manner. Accordingly, in neutrophils from hyper-IgE syndrome patients, who carry a nonfunctional STAT3, IL-10 failed to promote NF-kappaBp65 recruitment to the IL-1ra promoter and consequently to potentiate LPS-induced IL-1ra transcription. Altogether our findings uncover a novel mechanism whereby IL-10-activated STAT3 modulates IL-1ra transcription in LPS-treated phagocytes by making IL-1ra promoter accessible to readily available nuclear NF-kappaB.-Tamassia, N., Castellucci, M., Rossato, M., Gasperini, S., Bosisio, D., Giacomelli, M., Badolato, R., Cassatella, M. A., Bazzoni, F. Uncovering an IL-10-dependent NF-kappaB recruitment to the IL-1ra promoter that is impaired in STAT3 functionally defective patients
Quantifying the Dynamical Complexity of Chaotic Time Series
Full text linkAcknowledgements The author wishes to acknowledge G. Giacomelli, M. Mulansky, and L. Ricci for early discussions.Peer reviewe
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Le infrastrutture verdi e l’organizzazione insediativa
No full textNel quadro di una crescita indefinita dell’urbano, in seguito a continue addizioni di aree naturali o seminaturali, gli spazi aperti devono essere ripensati per il ruolo strutturale che rappresentano nell’organizzazione insediativa. Se tali spazi vengono troppo spesso considerati residui in attesa di essere urbanizzati, da questa dimensione deve partire la riorganizzazione insediativa, concentrandosi sul valore fondamentale degli ecosistemi per la società.
Al fine di favorire la ricostruzione di spazi urbani più sostenibili, i sistemi naturali caratterizzanti le aree interne e rurali dell’area di studio possono essere concepiti come infrastrutture verdi a sostegno della comunità, riconoscendo le molteplici funzioni che svolgono per il vivere e l’abitare dei territori. Per la comprensione di tale ruolo, la governance regionale necessita però di strumenti analitici in grado di riconoscere la multifunzionalità degli spazi aperti, alle diverse scale e ai diversi livelli di governo. Il contributo presenta i risultati del progetto di ricerca V.A.U.TE.RE.CO. (Valutazione degli Assetti Urbani e TErritoriali per la REsilienza delle COmunità), progetto regionale a supporto della definizione della Strategia Nazionale per lo Sviluppo Sostenibile, che lavora nel caso studio dei territori della regione Marche colpiti dal sisma2016-17 in rapporto con l’intero territorio regionale
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Un’infrastruttura verde regionale basata sulla domanda e offerta di Bundles di Servizi Ecosistemici. Una sperimentazione per le Marche
No full textI paesaggi sono il risultato di una continua interazione società-natura, i cui elementi sono interconnessi al punto che dovrebbero essere concepiti come un unico sistema socio-ecologico. In questo contesto, la pianificazione si trova davanti alla sfida di conciliare interessi settoriali concorrenti, al fine di garantire la multifunzionalità dei paesaggi ed il loro sviluppo sostenibile. In ambito accademico, il concetto di “Bundles” sta attirando interesse per la sua capacità di identificare insiemi di Servizi Ecosistemici (SE) che appaiono ripetutamente insieme nel tempo o nello spazio. Ad oggi, poche applicazioni tengono conto della prospettiva domanda-offerta e mancano dimostrazioni su come le caratteristiche dei sistemi locali influenzino i Bundles. Questa ricerca propone una nuova caratterizzazione funzionale dei paesaggi basata sulla domanda e offerta di Bundles di SE, associandoli ad asset socio-economici locali nel caso studio della Regione Marche
Un’infrastruttura verde regionale basata sulla domanda e offerta di Bundles di Servizi Ecosistemici. Una sperimentazione per le Marche
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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