1,721,049 research outputs found
The skill of probabilistic precipitation prediction under observational uncertainties within the Generalized Likelihood Uncertainty Estimation framework for hydrological applications
No full textA methodology for evaluating ensemble forecasts, taking into account observational uncertainties for catchment-based precipitation averages, is introduced. Probability distributions for mean catchment precipitation are derived with the Generalized Likelihood Uncertainty Estimation (GLUE) method. The observation uncertainty includes errors in the measurements, uncertainty as a result of the inhomogeneities in the rain gauge network, and representativeness errors introduced by the interpolation methods. The closeness of the forecast probability distribution to the observed fields is measured using the Brier skill score, rank histograms, relative entropy, and the ratio between the ensemble spread and the error of the ensemble-median forecast (spread-error ratio). Four different methods have been used to interpolate observations on the catchment regions. Results from a 43-day period (20 July-31 August 2002) show little sensitivity to the interpolation method used. The rank histograms and the relative entropy better show the effect of introducing observation uncertainty, although this effect on the Brier skill score and the spread-error ratio is not very large. The case study indicates that overall observation uncertainty should be taken into account when evaluating forecast skill.</p
Methods and models for functional studies on mtDNA mutations
No full textAfter 30 years of mitochondrial medicine, several models and methods for studying the pathogenic effects of mtDNA mutations have been developed. However, considering the difficulty to manipulate mtDNA, the possibility to obtain models for mitochondrial diseases remains challenging. Recently, the perspective to generate induced pluripotent stem cells from patients’ fibroblasts and differentiate them in specific cell populations or organoid has raised great interest for studying the molecular mechanisms of mitochondrial dysfunctions and for drug screening. Despite the technical hurdles, some animal models with mutations in mtDNA have been generated and represent valuable tools for the study of pathogenetic mechanisms and the test of new therapies. In parallel, biochemical methods for assessing mitochondrial function and efficiency are more and more sophisticated and developed on a small scale. Here, we summarize and discuss the different models and methods currently used to investigate the impact of mtDNA alterations on OXPHOS complexes function and structure
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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