1,720,981 research outputs found
Cinacalcet normalizza la calcemia sierica nei pazienti con iperparatiroidismo primitivo con controindicazioni alla chirurgia: studio randomizzato a doppio cieco
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Regulatory B (BREG) lymphocytes are increased in patients Hashimoto's thyroiditis and related autoimmune disorders
No full textA novel therapeutic approach for patients with gastric disorders and T4 malabsorption: thyroxine softgel preparation
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
the individually tailored thyroxine dose as a tool to unveil occult autonomous thyroid functioning areas
No full textAutonomous functioning thyroid areas (AFTA), frequently associated to heart arrhythmias, are often occult and may be associated to TSH values in the low-normal range. Despite the administration of an individually tailored dose (ITD) of thyroxine (T4) in the treatment of multinodular goitre (MNG), a serum TSH lower than expected may be obtained as a consequence of the presence of AFTA. This study was aimed at characterizing the existence of hidden AFTA in patients hyperresponding to treatment with an ITD of thyroxine. In a cohort of about 3000 consecutively examined outpatients, we assessed 94 patients (84 F and 10 M; median age=56 years) with MNG in treatment with ITD, who showed an unexpected lower serum TSH as compared to the one observed in a reference group (n = 123; 109 F and 14 M; median age=54 years) in whom iodine and drug interferences, as well as AFTA, were positively excluded. Patients in the study group showed significantly lower median TSH (0.052 vs 0.20 mU/l, P 60 years (median TSH:0.05 vs 0.22 mU/l, P < 0.0025; median T 4 dose:0.94 vs 1.33 g/Kg/day, P < 0.0005). Interestingly, when treatment was withdrawn, 86/94 patients (91.5%) had serum TSH in the normal range and the median TSH of the whole study group was 1.09 mU/l.
The presence of autonomous functioning areas has been detected, through thyroid scintiscan and radioactive iodine uptake test (RAIU- 4 th and 24 th hour), in 65 out of 94 patients (69%). RAIU at 4 th hour (17 vs 13%, P < 0.0199) and 24 th hour (33.5 vs 28%, P < 0.001) were both significantly higher in patients with autonomous functioning areas. These results show that the TD of T4 represents a novel tool to detect hidden autonomous functioning thyroid area
Individually tailored dose of thyroxine: a novel tool to detect occult autonomous thyroid functioning nodules
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