1,720,996 research outputs found
GENIAC: METODICHE INNOVATIVE PER LO SVILUPPO DI NUOVI INGREDIENTI E FORMULAZIONI PERSONALIZZATE NEL TRATTAMENTO DEL FOTOINVECCHIAMENTO INDOTTO DA STRESS OSSIDATIVO
No full textFirst microsatellite loci of red mullet (Mullus barbatus) and their application to genetic structure analysis in transboundaries Adriatic shared stock
No full textIn order to study the genetic structure of the Adriatic shared stock of red mullet (Mullus barbatus), we developed a set of dinucleotide microsatellite markers. A dinucleotide-enriched genomic library was obtained, and 6 polymorphic dinucleotide loci were successfully optimized. The markers showed high expected heterozygosity (from 0.68 to 0.92) and allele number (from 12 to 33); thus they appear to be suitable for detecting genetic differences in the population of red mullet. Four Adriatic samples were subsequently analyzed for microsatellite variation, and the results showed subtle but statistically significant genetic differentiation, indicating that the Adriatic red mullet may group into local, genetically isolated populations. No correlation between geographic distance and genetic differentiation was observed. In addition, the evidence of recent bottlenecks in the Adriatic samples indicates that the observed population subdivision might reflect random local allelic variations, generated by reproductive success, survival rates, or fishing pressure
Do we need a novel approach to the research and development of ingredients used for a customized treatment of photo-induced oxidative stress?
No full textCosmetogenomic is a branch of welfare science that studies the interaction between the genetic identity of an individual and his response to cosmetic treatments. It is widely documented that the bio-mechanical properties of skin are influenced by physiological processes and environmental agents that alter the structure. The aging process is directly related to the formation of free radicals, which accumulate in response to normal biochemical processes and environmental insults, including UV exposure. The main effect of UV exposure is the increase of the accumulation of mutations in nuclear and mitochondrial DNA. Mutations of mitochondrial DNA (mtDNA) have been extensively studied and it’s clear their correlation with the process of photoaging of the skin and many degenerative diseases.
Many studies have shown that the susceptibility to UV-induced damage is different in each person suggesting that preventive treatment can be customized on the base of individual genetic characteristics.
We have then decide to developed a new method (GENIAC) for the selection and evaluation of ingredients and formulations truly innovative and effective against DNA damage linked to free radicals
Nitric Oxide signaling disruption is associated with the maintenance of an undifferentiated status in imaginal tissues of D. melanogaster
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Developmental instability of the Drosophila wing as an index of genomic perturbation and altered cell proliferation
No full text: We experimentally induced different levels of instability affecting the development of specific wing regions of Drosophila melanogaster using the UAS-GAL4 system. A common index of developmental instability is fluctuating asymmetry (FA), that is, random differences between body sides of single individuals. We studied the FA in transgenic strains carrying random genomic insertions (UAS strains), as well as insertions in the regulatory region of genes involved in the organization of wing development (GAL4 strains). In addition, the expression of genes that increase (dp110 and 3622) or decrease (dPTEN) cell proliferation was ectopically induced. Our results are related to different levels of perturbation. Through the first kind of perturbation, genome integrity was compromised by the insertion of foreign DNA. In all cases, we observed a general increase in FA, although it was rarely found significant. The second kind of perturbation involved a modification of genes controlling wing development through the insertion of a GAL4 sequence in their promoter region. The third kind involved the ectopic expression of genes controlling cell proliferation. Our results show that (i) the level of FA is connected with the level of morphological perturbation induced, (ii) FA increase was higher in the wing regions that were the target of the genetic perturbation, and (iii) developmental instability was also observed in regions that were not directly addressed by the perturbation. The results were discussed on the basis of the running models about Drosophila wing development
The human protein Hugl-1 substitutes for Drosophila Lethal giant larvae tumour suppressor function in vivo
No full textFluctuating asymmetry as a measure of ecological stress in Drosophila melanogaster (Diptera: Drosophilidae)
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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