1,720,981 research outputs found
Multi-therapies in androgenetic alopecia: review and clinical experiences.
Full text linkAndrogenetic alopecia (AGA) is a genetically determined progressive hair-loss condition
which represents the most common cause of hair loss in men. The use of the medical term
androgenetic alopecia reflects current knowledge about the important role of androgens and genetic
factors in its etiology. In addition to androgen-dependent changes in the hair cycle, sustained
microscopic follicular inflammation contributes to its onset. Furthermore, Prostaglandins have been
demonstrated to have the ability in modulating hair follicle cycle; in particular, PGD2 inhibits hair
growth while PGE2/F2a promote growth. Due to the progressive nature of AGA, the treatment should
be started early and continued indefinitely, since the benefit will not be maintained upon ceasing
therapy. To date, only two therapeutic agents have been approved by the Food and Drug
Administration and European Medicines Agency for the treatment of AGA: topical minoxidil and oral
finasteride. Considering the many pathogenetic mechanisms involved in AGA, various treatment
options are available: topical and systemic drugs may be used and the choice depends on various
factors including grading of AGA, patients’ pathological conditions, practicability, costs and risks. So,
the treatment for AGA should be based on personalized therapy and targeted at the different
pathophysiological aspects of AG
Chemotherapy-induced alopecia management: Clinical experience and practical advice
Full text linkBackground:
Chemotherapy-induced alopecia (CIA) is probably one of the most
shocking aspects for oncological patients and underestimated by physicians. Among
hair loss risk factors, there are treatment-related aspects such as drug dose, admin-
istration regimen, and exposure to X-rays, but also patient-related characteristics. To
the best of our knowledge, no guidelines are available about CIA management.
Aims and methods:
With this study, based on literature background and our clinical
experience, we would like to propose a list of actions in order to estimate the risk
of hair loss before starting chemotherapy and to manage this condition before, dur-
ing, and after drug administration and to create a sort of practical guide for derma-
tologists and oncologists.
Results and conclusion:
There is an urgent need for prospective studies to clarify
the mechanistic basis of alopecia associated with these drugs and consequently to
design evidence-based management strategies
Dissecting cellulitis: Responding to topical steroid and oral clindamycin
No full textDissecting cellulitis of the scalp (DCS) is a rare disease, characterized by painful deep nodules and sinus tracts, discharging purulent secretions, principally localized at vertex and occiput. The development of chronic inflammation, caused by the primitive occlusion of the follicles, can lead to a patchy alopecia
A case of Scalp Rosacea treated with low dose doxycycline and probiotic therapy and literature review on therapeutic options
Full text linkRosacea is a common chronic inflammatory disorder showing a wide range of clinical features such as telangiectasia, erythema, papules, and pustules primarily involving the central part of face (forehead, cheeks and nose) although extra facial manifestation have been described. We describe a case of rosacea with predominant scalp involvement successfully treated with a 8-week-course of doxycycline 40 mg once a day and probiotic therapy twice a day (Bifidobacterium breve BR03, Lactobacillus salivarius LS01 1 × 10(9) UFC/dose)
Unusual patterns of presentation of frontal firbosing alopecia: a clinical and trichoscopic analysis of 98 patients
No full textClinical and trichoscopic correlation of primary neutrophilic scarring alopecia: folliculitis decalvans and dissecting cellulitis
No full textTrichoscopy is the term coined for the dermoscopic imaging of scalp and hair. This diagnostic technique, simple and noninvasive, can be used as a handy bedside tool for the diagnosis and follow-up of hair and scalp disorders.
It allows the recognition of morphologic structures not visible by the naked eye and provides the clinician with a range of dermoscopic findings necessary for differential diagnosis. Trichoscopy observation can be broadly grouped as interfollicular patterns and follicular patterns. Recently, a third mixed class, called the follicular plus interfollicular pattern, has been introduced. Some of these features are specific to a certain scalp disease, while others can be found in many hair disorders. Although studies suggest that the use of trichoscopy can improve clinical accuracy, further investigation is needed.
This review provides update information on the trichoscopic features of the most common scalp disorders, striving to show a histopathological and clinical correlation
Treatment of facial actinic keratoses with a cream containing octatrienoic acid: a multi center clinical experience
Full text linkActinic keratosis (AKs) are premalignant skin lesions characterized by high rate of transformation in squamous cell carcinoma if not treated. Pre-clinical published data on parrodiene-derivative 2,4,6-octatrienoic acid, encourages us to study andto evaluate the effect of a topical product containing it in patients affected by mild to moderate actinic keratosis
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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