1,721,010 research outputs found
The impact of recent next generation sequencing and the need for a new classification in gastric cancer
No full textThe phenotypical and molecular heterogeneity of gastric cancer has hampered the introduction in clinical practice of a unifying classification of the disease. However, as next generation sequencing (NGS) technologies enhanced the comprehension of the molecular landscape of gastric cancer, novel molecular classification systems have been proposed, allowing the dissection of molecular tumor heterogeneity and paving the way for the development of new targeted therapies. Moreover, the use of NGS analyses in the molecular profiling of formalin-fixed paraffin-embedded (FFPE) specimens will improve patient selection for the enrolment in novel clinical trials. In conclusion, the application of NGS in precision oncology will revolutionize the diagnosis and clinical management in gastric cancer patients
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Current role of non-coding RNAs in the clinical setting
No full textNon-coding RNAs (ncRNAs) have long been considered as “junk” material of the human genome until functional studies have exposed them as critical regulators of gene expression in both physiological and pathological conditions. Mounting evidences have also shown that ncRNAs may serve as diagnostic markers for several disorders, predictor for drugs response, and targets for new therapeutic approaches. In this mini-review, we discuss the state of the art of non-coding RNAs in drug development and their involvement in conventional treatments response
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Gastric xanthomatosis: a rare finding in the paediatric age.
No full textBackground: Gastric xanthoma are rare benign lesions most
frequently found in the antrum. They can be associated with
inflammation of the gastric mucosa, especially in patients with chronic
gastritis, Helicobacter pylori, intestinal metaplasia, bile reflux. Their
etiology is nevertheless not completely known as they are rarely
described. Just a few number of adult cases aging >35 years has been
reported [1], whereas to our knowledge only one previous paediatric
case was described as yet [2].
Specific aim: We report a rare paediatric case of gastric
xanthomatosis, whose endoscopic follow-up demonstrates the
evolution of lesions and their correlation with Proton Pump Inhibitors
(PPI) treatment administered.
Case Report: A 13 year old girl came to our attention for disphagia,
chest burning, feeling of regurgitation and rumination after each
meal. Neither abdominal pain, nor alteration in stool frequency were
referred. The clinical assessment was normal, except for a mild
decrease in body weight (from 25th to 10th percentile) with respect
to the height (50th percentile). The general blood tests performed
were all negative, gastro-panel included [3]. A first upper-GI tract
endoscopy previously performed had identified two whitish kissing
lesions with diameter of 0.3 cm surrounded by hyperhaemic mucosa,
in the middle of the small gastric curve, and a mild hyperhaemic antral
mucosa. The histologic examination demonstrated inactive chronic
gastritis at the antrum as well as in the areas next to the two lesions;
no Helicobacter pylori was detected. A therapeutic trial with PPI was
suggested and performed for one month, with only partial remission
of symptoms. Given a relapse of symptoms fifteen days after the
suspension of the PPI treatment, we decided to perform at our Unit
another upper-GI-tract endoscopy two months after the previous one,
in order to evaluate the effect of the ongoing treatment on the gastric
lesions. Six gastric lesions were found this time: they appeared as
nodules and soft pseudo-polyps and measuring 0.5−1 cm, with a
greyish-whitish top resembling a papilloma. The presence of bile
reflux was observed. The histologic examination evidenced foamy
histiocytes being compatible with gastric xanthoma.
Discussion: It is important not to misrecognize the nature of these
lesions, since they may present at endoscopy an ulcer-like aspect,
so that an anti-acidic treatment could be therefore inappropriately
prescribed. Taking biopsies during upper GI-endoscopy is thus
fundamental to diagnose gastric xanthoma as well as to exclude
gastric tumors.
Reference(s)
[1] Gravina AG, Iacono A, Alagia I, D’Armiento FP, Sansone S, Romano
M. Image of the Month: Gastric xanthomatosis associated with gastric
intestinal metaplasia in a dyspeptic patient. Dig Liv Dis 2009; 41: 765.
[2] Wetzler G, Felix AA, Lipton JF. Image of the Month: Gastric Xanthelasma.
Jour Ped Gastroenterol Nutr 2010; 51: 1.
[3] Guariso G, Basso D, Bortoluzzi CF, Meneghel A, Schiavon S, Fogar
P, Farina M, Navaglia F, Greco E, Mescoli C, Zambon CF, Plebani M.
GastroPanel: evaluation of the usefulness in the diagnosis of gastroduodenal
mucosal alterations in children. Clin Chim Acta 2009; 402(1−2):
54−60
Synchronous medullary, papillary and follicular carcinomas in the same thyroid: case report and review of literature.
No full text
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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