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Inhibition of adenosine uptake by selective inhibitors of phosphodiesterases in PC12 cells.
No full text
Biochemical and morphological changes in PC12 cells after short-term exposure to inhibitors of adenosine uptake and of cyclic AMP transporter.
No full textRole of nitrobenzylthioinosine-sensitive nucleoside transport in modulating the cyclic AMP response of PC12 cells to exogenous adenosine
No full textAmrinone potentiates catecholamine-induced lipolysis in fat cells
No full textAm&tone, a bipyridine derivative, exerts a positive
inotropic action in vitro 11-31 and in viuo 141. In addition,
the drug produces a marked relaxation of vascular [5,6]
and intestinal [5,7-91 smooth muscle.
In patients with cardiac failure the haemodynamic effects
of amrinone are accompanied by an increase in plasma
fatty acids and glycerol concentration [lo].
The present study was undertaken in order to test the
possibility that amrinone may exert a direct stimulatory
effect on hormone-sensitive lipolysis in fat cells. This
hypothesis is based on the consideration that amrinone
inhibits phosphodiesterase activity [3,11,12] and hinders
the response to endogenous adenosine [2,9] in various
tissues. In fat cells, cyclic AMP formation is an intermediate
step in the activation of triglyceride Iipase by hormones
and neurotr~s~tte~ interacting with stimulatory recep tors [13]. This activation can be also induced by agents, such
as methylxanthines, that act as antagonists at inhibitory
membrane receptors coupled to adenylate cyclase and/or
increase cyclic AMP levels by inhibiting phosphodiesterase
113-151.
Because of these similarities between the actions of amri none and of theophylline, a typical lipolytic methyl xanthine, the influence of the two drugs on lipolysis was
compared and their possible interaction at this level was
examined.
Finally, since activation of Ca2+ flux in vascular [5],
intestinal IS, 161 and cardiac muscle 13,171 is involved in
the final effects of amrinone, and many results indicate
an outstanding role of Ca2+ in the regulation of lipolysis
[18,20], the inguence of external Ca2+ concentration on
the effects of amrinone was also tested
[Interferon-alpha. Results of a pharmaco-epidemiologic study]
No full textIn the present study we evaluated the use of alpha-IFN in the ULSS 21 of Veneto Region. All outpatients treated with interferon during the period June-July 1992 (114 subjects) were interviewed using a standard questionnaire which was meant to collect information about therapy, side effects and quality of life. Alpha-IFN was mostly prescribed for chronic non-A non-B hepatitis (as approved by the FDA in the USA and by the Ministero della Sanità in Italy), while 35% of the patients were suffering from diseases for which interferon use is approved by Ministero della Sanità but not by FDA. In most cases, independently of the specific disease, a standard dose of 9 MU/week was used, which often resulted to be below the recommended doses reported in the literature. Adverse effects were frequently reported. The most common include fever, chills, headache, fatigue, myalgia. Mild mental disturbances (irritability and/or depression) and thyroid dysfunction were also reported but were less frequent. Finally, a negative influence of alpha-IFN therapy on the quality of life was reported by about half of the interviewed patients
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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