253 research outputs found
Is there really a power shortage in clinical trials testing the "homocysteine hypothesis?".
No full textG.J. Hankey, J.W. Eikelboom, K. Loh, Q. Yi, J. Pizzi, M. Tang, S. Hickling, M. Le, C.J. M. Klijn, P. Dusitanond, F. van Bockxmeer, A. Gelavis, R. Baker and K. Jamrozi
Heidegger and Religion 4: Heidegger and Religion: from Neoplatonism to the Posthuman
No full textPapers from the 4th Heidegger and Religion colloquium, held at Christ Church, May 24th 2008.The attached file contains the programme of the workshop 'Heidegger and Religion: from Neoplatonism to the Posthuman' (24 May 2008, Christ Church, Oxford) and full-text of the following papers presented at the workshop: Wayne Hankey - 'The Ineffable immediately Incarnate: Interplay between French 20th Century Neoplatonism and Heidegger'; Aidan Nichols - 'Von Balthasar and Heidegger'; Bradley Onishi - 'Heidegger and information technologies: tracing views of the posthuman'; Mark Sinclair - 'Heidegger and the technological Absolute' . Each author holds the copyright for their paper
Victim of the Japanese Evacuation and Resettlement Study (JERS)
No full textAn affidavit written to invalidate purported distortions and false accusations made against the author in two books published using research material collected by Rosalie Hankey Wax during de Cristoforo's incarceration at Tule Lake. The books are "Doing Fieldwork: Warnings and Advice" by Rosalie H. Wax and "The Spoilage" by Dorothy Swaine Thomas and Richard S. Nishimoto with contributions by Rosalie Hankey. The affidavit outlines and refutes information collected by Wax while working on the Japanese American Evacuation and Resettlement Study (JERS).The Robert Billigmeier collection is comprised of materials collected during his work and stay at the Tule Lake incarceration camp conducting research for the University of California’s Japanese Evacuation and Resettlement Study (JERS). The collection includes: photographs taken during his time at Tule Lake; a scrapbook created by students at Tule Lake in 1942; camp publications; reports and manuscripts; and student writings. Several of the reports and manuscripts draw from the personality cards written by students in the Tule Lake incarceration camp
Is There Really a Power Shortage in Clinical Trials Testing the "Homocysteine Hypothesis?"
No full textHomocysteine-lowering treatment with folic acid, cobalamin, and pyridoxine does not reduce blood markers of inflammation, endothelial dysfunction, or hypercoagulability in patients with previous transient ischemic attack or stroke: A randomized substudy of the VITATOPS trial
No full textPublished online before print November 29, 2004Background and Purpose— Epidemiological and laboratory studies suggest that increasing concentrations of plasma homocysteine (total homocysteine [tHcy]) accelerate cardiovascular disease by promoting vascular inflammation, endothelial dysfunction, and hypercoagulability. Methods— We conducted a randomized controlled trial in 285 patients with recent transient ischemic attack or stroke to examine the effect of lowering tHcy with folic acid 2 mg, vitamin B12 0.5 mg, and vitamin B6 25 mg compared with placebo on laboratory markers of vascular inflammation, endothelial dysfunction, and hypercoagulability. Results— At 6 months after randomization, there was no significant difference in blood concentrations of markers of vascular inflammation (high-sensitivity C-reactive protein [P=0.32]; soluble CD40L [P=0.33]; IL-6 [P=0.77]), endothelial dysfunction (vascular cell adhesion molecule-1 [P=0.27]; intercellular adhesion molecule-1 [P=0.08]; von Willebrand factor [P=0.92]), and hypercoagulability (P-selectin [P=0.33]; prothrombin fragment 1 and 2 [P=0.81]; D-dimer [P=0.88]) among patients assigned vitamin therapy compared with placebo despite a 3.7-µmol/L (95% CI, 2.7 to 4.7) reduction in total homocysteine (tHcy). Conclusions— Lowering tHcy by 3.7 µmol/L with folic acid-based multivitamin therapy does not significantly reduce blood concentrations of the biomarkers of inflammation, endothelial dysfunction, or hypercoagulability measured in our study. The possible explanations for our findings are: (1) these biomarkers are not sensitive to the effects of lowering tHcy (eg, multiple risk factor interventions may be required); (2) elevated tHcy causes cardiovascular disease by mechanisms other than the biomarkers measured; or (3) elevated tHcy is a noncausal marker of increased vascular risk.P. Dusitanond, J.W. Eikelboom, G.J. Hankey, J. Thom, G. Gilmore, K. Loh, Q. Yi, C.J.M. Klijn, P. Langton, F.M. van Bockxmeer, R. Baker and K. Jamrozi
Management of acute ischaemic stroke: new guidelines from the American Stroke Association and European Stroke Initiative
No full textItem does not contain fulltextBACKGROUND: Ischaemic stroke is an important cause of death and dependency in industrialised countries; it has a high incidence (affecting up to 0.2% of the population each year) and is commonly lethal or disabling. One in six patients die in the first month after ischaemic stroke, and half of survivors are permanently disabled despite best efforts to rehabilitate them and to prevent complications, recurrent stroke, and other serious vascular events. Optimisation of the early, and ongoing, management of patients with acute ischaemic stroke is pivotal to the reduction of both case fatality and long-term disability. RECENT DEVELOPMENTS: Guidelines for the early management of patients with ischaemic stroke have recently been published by the Stroke Council of the American Stroke Association (ASA; Adams and co-workers, Stroke 2003; 34: 1056-83) and the European Stroke Initiative (EUSI; European Stroke Initiative Executive Committee and Writing Committee, Cerebrovasc Dis 2003; 16: 311-38). Although transatlantic differences might create different interpretations, priorities, and views, the guidelines are remarkably similar, even regarding controversial issues. We believe this is not only because both groups have had the opportunity to discuss many of the controversial issues at international meetings, but also because both groups have endorsed the concept of evidence-based medicine and have based their recommendations on similar classifications of the levels of evidence for the effectiveness of interventions. This is a triumph for evidence-based medicine and a major step towards unification of acute stroke management worldwide. WHERE NEXT?: There are three main challenges in stroke management. To increase the body of reliable evidence from large randomised controlled trials (RCTs) of the safety, effectiveness, and cost of promising treatments (eg, thrombolysis, antithrombotic therapy, neuroprotection, and interventional recanalisation, alone and in combination) in a wide range of patients around the world. To facilitate the widespread development of stroke units, delivery of organised stroke care, and emergency transport of patients with stroke to appropriate stroke centres. And finally, to improve the uptake of effective therapies into clinical practice (eg, by widely disseminating the ASA and EUSI guidelines)
Milky way halo objects, IC 4499 and the large magellanic cloud
No full textThe work described in this thesis is that of the candidate alone, except where otherwise acknowledged in the text. The observations of IC 4499 at the AAT were carried out by my supervisor Dr. Andrew A. Cole but the candidate was responsible for the reduction process and all subsequent analysis. The IC 4499 material in this thesis was published in the Monthly Notices of the Royal Astronom- ical Society, volume 411, pages 1536 to 1546, March 2011, with the candidate as first author and with Dr. Cole as co-author contributing part of the discussion. MNRAS hold the copyright for that content, and access to the material should be sought from the journal. The remaining non published content of the thesis may be made available for loan and limited copying and communication in accordance with the Copyright Act 1968. The Monte Carlo Markov Chain program to estimate the velocity dispersion and mass in IC 4499 was scripted in R by Dr. Simon Wotherspoon. The candidate substantially adapted the code and methodology to the larger problem of estimation of LMC rotation model parameters. LMC target selection, field plate setup, sky-fibre, and guide star placement were all carried out by the candidate, Dr. Cole travelled to the AAT to assist with the final LMC observations. Reduction and analysis of the LMC data is that of the candidate alone. Dr. Cole performed a calibration check of the LMC metallicity results and Appendix D is entirely his work. Thanks to Dr. Cole for encouragement, discussions and assistance. Observations at the Mount Pleasant radio telescope supporting the JAXA Selene Moon mission resulted in a co-author credit in Radio Science, volume 45, number 2, April 2010. Travel support for observing was provided by the Anglo-Australian Observatory (AAO). The AAO was funded by the British and Australian governments. Thanks to AAT support astronomer Dr. Rob Sharp and night assistant Winston Campbell for their assistance during the observing run
Higher serum free testosterone is associated with better cognitive function in older men, while total testosterone is not. The health in men study
No full textObjective: To determine the relationship of total and free serum testosterone to cognitive performance in older men. Design: Cross-sectional study of a population-based sample. Participants: A total of 2932 men aged 70–89 years. Measurements: Cognitive function was assessed using the Standardized Mini-Mental State Examination (SMMSE). Early morning sera were assayed for total testosterone, SHBG and LH. Free testosterone was calculated using the Vermeulen method. Results: There were weak positive correlations between SMMSE score and serum free testosterone (Spearman's rho = 0·06, P = 0·001) and total testosterone (r = 0·04, P = 0·027), and a weak negative correlation with LH (r = −0·07, P < 0·001). Men with SMMSE scores in the top quintile had higher serum free testosterone compared with those in the lowest quintile [median (interquartile range, IQR): 278 (228–335) vs. 262 (212–320) pmol/l, P = 0·003], but similar total testosterone [15·2 (11·9–18·8) vs. 14·8 (11·6–18·3) nmol/l, P = 0·118]. Increasing age, non-English-speaking background, lower educational attainment, presence of clinically significant depressive symptoms, and cardiovascular morbidity were associated with the lowest cognitive performance quintile. After their effects were taken into account in a multivariate analysis, serum free testosterone ≥ 210 pmol/l was associated with reduced likelihood of poor cognitive performance on the SMMSE [odds ratio (OR) 0·71, 95% confidence interval (CI) 0·52–0·97]. Conclusions: In community-dwelling older men, serum free testosterone ≥ 210 pmol/l is associated with better cognitive performance. In this context, calculated free testosterone seems to be a more informative measure of androgen status than total testosterone. Studies examining the contribution of androgens to age-related cognitive decline should incorporate an assessment of free testosterone concentration.Bu B. Yeap, Osvaldo P. Almeida, Zoë Hyde, S. A. Paul Chubb, Graeme J. Hankey, Konrad Jamrozik and Leon Flicke
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