1,720,975 research outputs found
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF CYCLIC AND OPENED THIOANALOGUES OF PIPEROXAN
No full textThree piperoxan analogues, derived from the opening of the benzodioxane ring and/or replacement of the oxygen atom with the less polar sulfur, were synthesized. The decrease of the -blocking activity found for these compounds showed that the binding site of benzodioxane-like compounds does not accept the substitution with less polar groups
SYNTHESIS AND PHARMACOLOGICAL EVALUATIONOF PROPRANOLOL-CYCLIC ANALOGUES
No full textThree propranolol analogues' bearing the oxygen ol the-OH group enclosed in a 1,4-dioxanic ring system,were synthetized.The lack of beta-blocking activity found for these compounds demonstrates theimportant role played by a free -OHgroup in the drug-receptor interaction
Synthesis and pharmacophore generation of new pyridazinone derivatives with affinity towards alpha1-alpha2 adrenoceptors
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Synthesis and biological activity of new 1,4-benzodioxan-related compounds. Further validation of a pharmacophore model for alpha1-adrenoceptors
No full textSYNTHESIS AND PHARMACOLOGICAL EVALUATIONOF SOME V/84101 ANALOGUES BEARING ANAPHTODIOXANIC NUCLEUS
No full textThree WB4101 analogues, bearing system a 1,4-naphtodioxanic system, were svnthesized.. The decrease of alpha-blocking activity found for these compounds. showed that extension of aromatic area in the dioxanic mojety of such benzodioxanic deerivative, hinders the drug-receptor interaction
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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