143 research outputs found
Alessandro Bosi, Una città per raccontarsi, in Anita Gramigna, Carlo Pancera (a cura di), Poietica dell'educazione, Este Edition, Ferrara, 2012, pp. 41-52.
No full text
[Clinical evaluation of metolazone in edematogenic syndromes]
No full text[Clinical evaluation of metolazone in edematogenic syndromes
Intensive weekly chemotherapy for locally advanced gastric cancer using 5-fluorouracil, cisplatin, epidoxorubicin, 6S-leucovorin, glutathione and filgrastim: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD).
No full textLocal extension prevents curative resection in more than two-thirds of gastric cancer patients. Unfortunately, resectability is one of the main prognostic factors in these patients, and survival is longer when tumours are completely removed. Preoperative chemotherapy is an attractive concept for obtaining curative resection. Thirty-two locally advanced unresectable gastric cancer patients were enrolled in five Italian Group for the Study of Digestive Tract Cancer (GISCAD) centres. For 16 patients, surgical unresectability was based on computerized tomography scan evaluation of tumour size (four patients) and invasion of adjacent structures (12 patients), whereas in another 16 patients locally advanced disease was confirmed by laparotomy. They received weekly administration of cisplatin 40 mg m(-2), 5-fluorouracil 500 mg m(-2), epidoxorubicin 35 mg m(-2), 6S-stereoisomer of leucovorin 250 mg m(-2) and glutathione 1.5 g m(-2). From the day after to the day before each chemotherapy administration, filgrastim was administered by subcutaneous injection at a dose of 5 microg kg(-1). One cycle of therapy consisted of eight weekly treatments. Fifteen of 32 patients (47\%) responded to chemotherapy, whereas 13 (41 \%) had stable disease and four (12\%) progressed on therapy. Of the 15 responding patients, 13 were completely resected after chemotherapy and two of them had a complete pathological response. Two clinically responding patients were found unresectable at operation because of peritoneal seeding. At a median follow-up from the start of treatment of 24 months (range 11-39 months), 10 of 13 resected patients are alive and eight are relapse free. Three patients died after 11, 12, and 14 months respectively. Toxicity was acceptable: side-effects consisted mainly of grade II National Cancer Institute common toxicity criteria (NCICTC) leucopenia and thrombocytopenia in ten patients. Neither treatment-related death nor surgical complications in patients undergoing surgery were observed. This weekly intensive regimen enabled resection in half of previously inoperable tumours with a moderate toxicity. It can be offered to patients with locally advanced unresectable gastric cancer to obtain curative resection
Pharmacokinetics of ceftazidime and ceftriaxone and their penetration into the ascitic fluid
No full textPharmacokinetics of ceftazidime and ceftriaxone and their penetration into the ascitic fluid
Evidence of parasympathetic impairment in some patients with cardiac syndrome X
No full textObjectives: Cardiac syndrome X (SX) is a clinical condition characterised by angina, positive exercise stress test and negative coronary angiography it has often been attributed to sympathetic hyperactivity. Here we tested the hypothesis that a parasympathetic, rather than a sympathetic, dysfunction could be the cause of the autonomic imbalance observed in SX. Methods: In 20 subjects with diagnosed SX and in 12 age-matched controls, we studied autonomic function by performing spectral analysis of RR interval and finger arterial pressure (SAP), in supine position and during head-up tilting. We also carried out a set of tests of parasympathetic function. Results: The group of SX patients did not differ significantly from control subjects in any of the variables tested. In a subgroup of 13 SX, however, tilting increased the low-frequency power of SAP, but did not induce the expected increase in low-frequency and decrease in high-frequency power of RR. These patients, in supine position, had significantly lower sinus arrhythmia and a higher ratio of low to high frequency of RR, in comparison with control subjects. We interpreted these differences as signs of reduced parasympathetic, but essentially normal sympathetic, activity. The parasympathetic tests confirmed vagal impairment in the same SX subjects. On the other hand, all the tests indicated normal parasympathetic functions in the control subjects and in those SX patients who displayed the expected spectral changes in tilting. Conclusions: In about two thirds of the patients with SX, the pathophysiological mechanism causing the symptoms could be related to the reduced parasympathetic tone, rather than to an augmented sympathetic activity. (C) 2001 Elsevier Science B.V. All rights reserved
An innovative method to model run-out phenomena in micro-milling by using cutting force signal
No full textThis work deals with the modeling of micro-milling processes by considering the phenomena generated by the transition from conventional size to the micro-scale machining. The concomitant effects of different cutting regimes, and the deviation of the cutting edges from their theoretical trajectories due to tool run-out, are important aspects to be considered during the process modeling. Several models are available in literature to describe how ploughing and shearing regimes influence cutting forces and how the tool run-out impacts on the actual chip thickness. In a previous authors research, a comprehensive model was published achieving a good agreement with the experimental data, but its calibration requires the measurement of the width of the micro-milled slots. This practice is time consuming and subjected to experimental errors, while a calibration of the model based only on the elaboration of the cutting force signal appears a promising strategy. Starting from the mathematical description of the geometrical model, a new equation to compute the tool run-out parameters was found. The parameters depend on eight variables that must be calculated from tool geometry, material composition, cutting parameters and the cutting force signal. An experimental procedure was developed to compare the prediction achieved by the new method and the conventional technique
Totally implantable venous devices in clinical oncological practice: A single institution experience
No full textAim. Long-term central venous catheters in cancer patients have become standard procedure for prolonged infusional therapy, for both chemotherapy and supportive care. A wide range of potential complications related to implants procedure and catheter management are described, but their low prevalence allows the increasing use in oncology. Methods. The authors report their single institution experience in 125 consecutive neoplastic patients. Operative procedures for totally implantable venous access device and catheters management are described. Results. The immediate complications were pneumothorax (4%), wound bleeding (1.6%) and incorrect catheter position (0.8%). Late complications included local or systemic infections (4%), vascular thrombosis (3.2%) and catheter permanent occlusion (0.8%). Conclusion. The conclusion is drawn that with long-term usage of totally implantable venous access device the complication rate remains low, making it a safe and well-accepted procedure
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