181 research outputs found
Florica Moisil, Dan Zamfirescu et G. Mihăilă, Învăţăturile lui Neagoe Basarab către fiul său Theodosie. Dan Zamfirescu, Neagoe Basarab şi Învǎţǎturile cǎtre fiul šau Theodosie
No full textDarrouzès Jean. Florica Moisil, Dan Zamfirescu et G. Mihăilă, Învăţăturile lui Neagoe Basarab către fiul său Theodosie. Dan Zamfirescu, Neagoe Basarab şi Învǎţǎturile cǎtre fiul šau Theodosie. In: Revue des études byzantines, tome 32, 1974. p. 395
Neagoe Basarab – modelul „omului desăvârșit și întreg”
No full textThis article is about the teachings of Neagoe Basarab in regards to the behavior of the future ruler. They are presented as a manual for practical morals where the orthodox faith intertwines with the bravery, merging the attributes of the Saint with those of the Hero. The religious significances of this moral code can be found under double appearance, for both division of the virtues (“Indwelling of God”, fasting, patience, love, gentleness, humility) and meeting of sins (lack of moderation in regards to gastronomy, drinking, gossiping, laughter and women, believed to be behind the many sins). Besides the theological instruction, the teachings of Neagoe Basarab puts into the foreground a moralist who knows the pitfalls and subtleties of the language, the finesse of meditation and the skill to push ideas to metaphysics. After Acad. Eugen Simion had commented the discursive levels of the chapters devoted to medieval diplomacy and art of the adorned speech (the parables and biblical parables), in the third part of this study the author focuses on the general meanings of the Teachings … Along with other specialists (Dan Zamfirescu, G. Mihăilă), the author believes that the paternity of the work belongs to Neagoe Basarab – even if specialists’ talks remain open – and this work, written in a liturgical language and translated into Romanian after a century, it has to be added to Romanian literary heritage. This real treatise – with teachings addressed to those who aspire to become fulfilled and upright people – does not avoid any of the great virtues of the ruler (in which Neagoe Basarab embodies the heroism and sanctity vocations) and it is our first masterpiece
Spectroscopy
No full textThroughout the day, we apply experimental methods to estimate time, mass, volume, distance, velocity, and temperature—how much to eat (mass), what clothes to wear (temperature), how long will it take to get somewhere (distance, velocity, and time). Preparing a meal requires some precision with respect to these factors, and the kitchen was the first laboratory for chemists and engineers. We continue to share many concepts related to instrumentation and experimental design. This book presents the basic principles of measurement particular to chemical engineering. Redacting this manuscript has been a collaborative effort; its original inspiration was J.P. Holman’s textbook entitled “Experimental Methods for Engineers.” In this 2nd edition, we revise the text entirely, correct typos (and other errors), and add a chapter on mass and distance and spectroscopy. Each chapter begins with a historical perspective to recognize the work of early pioneers but also to stimulate the imagination of the students. For example, 10 000 years ago, man created plaster from limestone. Plaster requires temperatures nearing 900°C, which is 150°C higher than an open pit fire. It requires 1000 kg of wood (chopped by stone axes), 500 kg of limestone, a pit 2 m in diameter and 0.7 m deep, rocks to insulate, and two days to burn. Modern manufacturing errors are costly and a nuisance; in prehistoric times, errors would have been considerably more than just an inconvenience.
In Chapter 1, we list the seven steps of the scientific method and review the rules of nomenclature—units of physical quantities, abbreviations, conversion between SI and British Units, writing convention. Chapter 2 introduces significant figures and what we mean by accuracy, precision, and error analysis. In this second edition, we report an explicit equation to calculate how many experiments are necessary to achieve a specified confidence interval. Chapter 3 reviews data analysis including hypothesis testing, data smoothing, and statistical tests. We summarize design of experiments, and we include more detail in this edition to describe factorial designs, outlining them and other complementary designs with detailed examples. Chapter 4 is new and introduces stress, strain, and electrical properties that relate to manufacturing sensors for mass and force. We apply these concepts in Chapters 5 and 6 that deal with pressure and temperature measurements. In each of these chapters, we first review basic concepts, including thermodynamics. Then we describe the sensors that rely on mechanical and electrical properties.
Chapters 7 and 8 continue with chemical engineering fundamentals of fluid flow and physicochemical properties. The former begins with Bernoulli’s equation and Reynolds number, then lists common flow meters. The three physicochemical properties that Chapter 8 presents include viscosity, thermal conductivity, and diffusion. It demonstrates how these properties are related and introduces non-dimensional numbers. Examples throughout the book help the students grasp the mechanics of solving problems but also to underline pitfalls in solving them. Measuring gas and liquid concentration by chromatography and mass spectrometry is the subject of Chapter 9. In this edition, we dedicate more scope to troubleshooting the chromatographic instruments. Spectroscopic instruments we detail in Chapter 11. This summary includes sections written by eminent chemists. We have selected the most powerful techniques used to characterize the physicochemical properties of solids and include infrared spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, nuclear magnetic resonance, UV/Vis, X-ray absorption, and refractometry Whereas Chapter 11 probes the nature of the solids phases, composition and morphology, Chapter 10 concentrates on powder properties—particle shape, size distribution, density, and surface area. The first edition of this book was a collaborative effort in which Melina Hamdine early on drafted several chapters in French, including Physicochemical Properties, Analysis of Powders and Solids, and Design of Experiments. Prof. Bala Srinivasan contributed to Chapter 3 on experimental design. Katia Senécal was “instrumental” in gathering the essential elements for the chapters, including Measurement Analysis, Pressure, Temperature, and Flow Rate. Prof. Bruno Detuncq collaborated in the revision of these chapters. Danielle Béland led the redaction of the chapter on chromatography to determine concentration, with some assistance from Cristian Neagoe. He also wrote the section concerning spectroscopy. Amina Benamer contributed extensively to this project, including preparing solutions to the problems after each chapter, writing sections related to refractometry and X-ray, and translating. Second-year students from the Department also participated by proposing original problems that were added at the end of each chapter (together with the name of the author of the problem). I would particularly like to recognize Paul Patience for his tremendous contribution throughout the creative process of preparing this manuscript. The depth of his reflection has been appreciated tremendously (LATEX). He also co-authored the section on pyrometry. Christian Patience prepared many of the drawings and Nicolas Patience helped with translating from French to English, as did Nadine Aboussouan.
This second edition is no less a collaborative effort. Ariane Bérard expanded Chapter 3 with examples of experimental designs. Prof. J. Gostick contributed the chapter on Mass and Force instrumentation. Stefano Lucini wrote the section on troubleshooting GC and HPLC instruments, while F. Galli contributed to the section on mass spectrometry with Patrice Perreault, who was devout at identifying errors and proposing additional problems. Marco Rigamonti and He Li wrote sections of Chapter 10. Collaborators on Chapter 11 included Daria C. Boffito, Cristian Neagoe, Giuseppina Cerrato, Claudio Boffito, Gian Luca Chiarello, Claudia L. Bianchi, Marco G. Rigamonti, and Amina Benamer. This chapter is a tremendous contribution to the book because it details simply which instruments measure which physicochemical property and then describes how they work
Macrophages Interaction and MicroRNA Interplay in the Modulation of Cancer Development and Metastasis
No full textAdvancement in cancer research has shown that the tumor microenvironment plays a crucial role in the installation, progression, and dissemination of cancer cells. Among the heterogeneous panel of cells within the malignant microenvironment are tumor-associated macrophages that are sustaining the malignant cells through strict feedback mechanisms and spatial distribution. Considering that the presence of metastasis is one of the main feature associated with decreased survival rates among patients, in the present article we briefly present the involvement of tumor-associated macrophages in the hallmarks of metastasis and their microRNA-related regulation with a focus on lung cancer in order to coordinate the vast information under one pathology. As shown, these cells have emerged as coordinators of immunosuppression, angiogenesis and lymphangiogenesis, vessel intravasation and extravasation of cancer cells, and premetastatic niche formation, transforming the macrophages in potential therapeutic targets and also prognostic markers according to their density within the tumor and polarization phenotype. An indirect therapeutic approach on tumor-associated macrophages can be also represented by regulation of microRNAs involved in their polarization and implicit oncogenic features. Examples of these microRNAs consist in the highly studied miR-21 and miR-155, but also other microRNA with less feedback in the literature: miR-1207-5p, miR-193b, miR-320a, and others
Beyond conventional: The new horizon of anti-angiogenic micrornas in non-small cell lung cancer therapy
No full textGLOBOCAN 2018 identified lung cancer as the leading oncological pathology in terms of incidence and mortality rates. Angiogenesis is a key adaptive mechanism of numerous malignancies that promotes metastatic spread in view of the dependency of cancer cells on nutrients and oxygen, favoring invasion. Limitation of the angiogenic process could significantly hamper the disease advancement through starvation of the primary tumor and impairment of metastatic spread. This review explores the basic molecular mechanisms of non-small cell lung cancer (NSCLC) angiogenesis, and discusses the influences of the key proangiogenic factors—the vascular endothelial growth factor-A (VEGF-A), basic fibroblast growth factor (FGF2), several matrix metalloproteinases (MMPs—MMP-2, MMP-7, MMP-9) and hypoxia—and the therapeutic implications of microRNAs (miRNAs, miRs) throughout the entire process, while also providing critical reviews of a number of microRNAs, with a focus on miR-126, miR-182, miR-155, miR-21 and let-7b. Finally, current conventional NSCLC anti-angiogenics—bevacizumab, ramucirumab and nintedanib—are briefly summarized through the lens of evidence-based medicine
Courier, Vol.X, No.2, Winter 1973
No full textThe Westcotts and David Hamm / Richard G. Case, p.3 -- The Romanian Village in Peter Neagoe\u27s Short Stories / loan A. Popa, p.15 -- Inside Bird, p.25 -- The Mayer Wetherill Collection: Music of the Nineteenth Century / Peter Korff, p.36 -- Open for Research ... Notes on Collections, p.44 -- News of the Library and Library Associates, p.4
Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2
No full textRedis, R.S., Vela, L.E., Lu, W., Ferreira de Oliveira, J., Ivan, C., Rodriguez-Aguayo, C., Adamoski, D., Pasculli, B., Taguchi, A., Chen, Y., Fernandez, A.F., Valledor, L., Van Roosbroeck, K., Chang, S., Shah, M., Kinnebrew, G., Han, L., Atlasi, Y., Cheung, L.H., Huang, G.Y., Monroig, P., Ramirez, M.S., Catela Ivkovic, T., Van, L., Ling, H., Gafà, R., Kapitanovic, S., Lanza, G., Bankson, J.A., Huang, P., Lai, S.Y., Bast, R.C., Rosenblum, M.G., Radovich, M., Ivan, M., Bartholomeusz, G., Liang, H., Fraga, M.F., Widger, W.R., Hanash, S., Berindan-Neagoe, I., Lopez-Berestein, G., Ambrosio, A.L.B., Gomes Dias, S.M., Calin, G.A
Courier, number 29, 1968
No full textFront cover(description) -- Swinburne\u27s Autumn in Cornwall -- The Greatest America: A close-up -- S.C. [Stephen Crane] at S.U. -- A Friend gone for a while -- From Mrs. Anna Neagoe -- War declared -- Lafacadio Hearn\u27s The Perfume of Women -- No more Smith -- Hart Crane -- In memory of Rufus Stanley Miller -- More Fred Ellis -- Ekholm of Ithaca -- A few more words abiout Emma G. -- Collectors choice -- A New Voltaire Lette
ELEMENTE DE TEOLOGIE ÎN OPERA LUI DIMITRIE CANTEMIR
No full textIn the history of Orthodox theological thought, the name of Dimitrie Cantemir should be placed among the important Romanian personalities such as Neagoe Basarab, Petru Movilă, and Nicolae Milescu Spătarul. There are some Cantemir’s works which form a substantial part pf this specific topic such as: „The Divan or The Wise Man's Parley with the World or The Judgment of the Soul with the Body”, the third part of Description of Moldova and others. Cantemir used to write his works while Baroque culture was blooming both in Europe and Romanian counties. So, it was favorable to use the same literary motives as fortuna labilis and vanitas vanitatum which are familiarly to earlier medieval works as The Teachings of Neagoe Basarab to his Son (written in Slavonic in 513-1521, translated in Romanian in 1654) or The Life of the World (1671-73) by Miron Costin. Another Cantemir’s important work is An introduction to Islam written for Europeans, in which the author expresses an Christian vision upon Muslim religion
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