1,720,954 research outputs found
Diagnostic analysis of concrete dams based on seasonal hydrostatic loading
No full textThe procedure proposed and examined in this paper for diagnosis of possible damage in aged large concrete dams can be outlined as follows. Zone-wise uniform Young’s moduli of concrete are traditionally the parameters to identify as representative of structural damage due to past physico-chemical processes
or/and extreme loads. Change of reservoir level with annual periodicity in plant service is considered as inexpensive significant external action for nondestructive diagnostic experiments. Many displacements, concomitant with the transition from highest to lowest level, are measured on the downstream surface of the dam by radar instruments, which at present are promising innovations in dam engineering.
Clearly nonnegligible contributions to measurable displacements due to seasonal thermal effects are taken into account by temperature measurements at time intervals through thermometers inside the dam, identification by them of parameters governing simplified thermal boundary conditions, timedependence expressed by truncated Fourier series over a one-year period. Finally, damage diagnosis is carried out by minimization, with respect to the sought Young’s moduli, of a batch discrepancy function between measured and computed displacements, as inverse analysis in a linear thermoelasticity context.
The proposed method is computationally validated also through its stochastic extension
CD and Fluorescence Screening of α-Synuclein-Peptide Interactions.
No full textα-Synuclein (AS), a natively unfolded protein, is the major components of the intracellular protein-aggregates, the Lewy bodies, found in the dopaminergic neurons of Parkinson's disease patients. The aggregates called "protofibrils," an intermediate in the fibrillogenesis process, are more cytotoxic than the amyloid-like fibrils in most of the proteins which generate fibrils. On one hand, aggregation inhibitors are expected to reduce AS cytotoxicity by preventing protofibril formation; on the other, an aggregation accelerator has recently been reported to reduce AS cytotoxicity, likely by causing protofibril precipitation. Therefore, amyloid aggregation modulating ligands are expected to serve as therapeutic medicines.
In the present study, we evaluated the interaction of peptide ligands with AS by CD and fluorescence spectroscopies. For this purpose, we synthesized two peptides, H-RKVFYTW-NH2 and H-RGAVVTGR-NH2, named BB1 and BB2, respectively, and their all-D amino acid analogues. In addition, a rotamer-scan of the phenylalanine residue into the BB1 peptide was performed with the aim to evaluate the influence of the topography of this residue in the binding process. To this end, the Phe residue was replaced by L- or D-NMePhe, L- or D-Tic and Ala residues.
Far-UV CD studies showed that AS conformation was strongly influenced by the interaction with these peptides. While the interaction with BB1 and BB2 induced an increase of the negative band at 198 nm, suggesting a corresponding increase of the unordered conformation of AS, other peptides caused a decrease of the same band. Surprisingly, L-NMePhe and L-Tic BB1 analogues did not interact with AS. The binding properties of the BB1 analogues was also confirmed by near-UV CD and fluorescence spectroscopies
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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