225 research outputs found
Central indwelling catheter to prevent phlebosclerosis by Peptichemio in patients with multiple myeloma
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Monoclonal antibody Ki-67 as marker of proliferative activity in monoclonal gammopathies.
No full textDeformation history of ultra high-pressure ophiolitic serpentinites in the Zermatt-Saas zone, Créton, upper Valtournanche (Aosta Valley, Western Alps)
No full textDetailed multiscale structural analyses and mapping (1:20 scale) integrated with petrological investigation were used to study a portion of the Zermatt-Saas serpentinites that crop out in upper Valtournanche (north-western Italy). Results are synthesized in a foliation trajectory map that displays the transposed original lithostratigraphy of a serpentinite body exposed at Créton. The serpentinite body comprises magnetite sheets and rare, decimetre-thick, diopsidite layers and lenses. Moreover, veins and aggregates of Ti-chondrodite and Ti-clinohumite, olivine-rich layers and lenses, veinlets of olivine, and layers of dark pyroxenite are embedded in the serpentinites. Serpentinites and associated rocks record three relative age groups of ductile structures: D1 consists of rare folds and S1 foliation; D2 is a group of isoclinal folds and a very pervasive foliation (S2), which is the dominant structure; D3 includes a crenulation and shear zones affecting S2. The detailed meso-structural and microstructural analyses allowed individuating the metamorphic environment of successive deformation stages and correlating the resulting tectono-metamorphic investigation with those already inferred in surrounding areas. In addition, metre- to submillimetre-sized pre-D2 structural, mineralogical, and textural relics have been clearly identified in spite of the strong transposition imposed during the development of S2 high pressure - ultra-high pressure foliation
Repeated aripiprazole treatment regulates Bdnf, Arc and Npas4 expression under basal condition as well as after an acute swim stress in the rat brain
No full textDespite the rapid control of schizophrenic symptoms is due to the ability of antipsychotic drugs (APDs) to block D2 receptors in the mesolimbic pathway, it is now well-established that the therapeutic effects rely on adaptive mechanisms set in motion by their long-term administration. Such neuroplastic mechanisms depend on the pharmacological profile of the drug employed, with marked differences existing between first and second generation APDs. On these bases, the major accomplishment of this work was to investigate neuroadaptive changes set in motion by repeated treatment with aripiprazole, a novel APD that is unique for being a partial agonist at dopamine D2 receptors. Moreover, given that stress plays a critical role in the exacerbation of disease symptoms, we also investigated whether aripiprazole could influence the dynamic response of the brain to an acute challenge. We found that repeated aripiprazole treatment in rats regulates the expression of different markers of neuroplasticity such as Bdnf, Arc and Npas4 in a brain-region specific fashion; more importantly, the expression of these molecules was significantly up-regulated by an acute swim stress only in aripiprazole-treated animals, which is suggestive of increased ability to cope with the adverse event. We indeed found an overall facilitation of Bdnf expression, an effect that is mainly evident in the prefrontal cortex on the pool of transcripts undergoing dendritic localization. Overall, our results provide novel information regarding the mechanisms through which aripiprazole may regulate brain function and could contribute to improve neuroplastic defects that are associated with schizophrenia symptomatology
Presentation features of monoclonal gammopathies: analysis of 684 newly diagnosed cases.
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