1,721,092 research outputs found
High dose intravenous IgG in immune diseases: A rational approach to off-label uses [La prescrizione delle immunoglobuline IgG ad alte dosi in malattie del sistema immunitario. Criteri di uso off-label e razionale: Critica della ragion pratica]
No full textTreatment with intravenous immunoglobulins IgG has been approved for immunodeficiencies and various immunerelated diseases, including thrombocytopenic purpura, demyelinating neuropathies, Guillain-Barré syndrome, and Kawasaki disease. In the past thirty years, off-label Intravenous Immunoglobulin IgG treatment of an increasing number of disorders has shown to be a useful approach with good clinical results. Here we review the rational approach to off-label use of high dose Intravenous Immunoglobulins IgG in several diseases, and the complex different mechanisms of action, including expression and function of Fc receptors, modulating idiotype network, complement and cytokine interactions, and natural antibodies role. The potential of recently introduced subcutaneous administration of immunoglobulins IgG is briefly discussed
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Scavi archeologici nell'area delle terme romane a Tifernum Mataurense (Sant'Angelo in Vado - PU) per il biennio 2017-2018 (XVII e XVIII campagna)
No full textIl progetto prevede il proseguimento delle indagini di scavo stratigrafico a Tifernum Mataurense, odierna Sant'Angelo in Vado (PU) ad opera dell'Università di Macerata, che qui opera dal 2000; in particolare le ricerche riguarderanno l'area delle terme romane, di cui verranno indagati il settore centrale (Testimone B) e quello meridionale (quadrante II)
Vado per la città antica
No full textNel biennio 2015-16 durante la XV e la XVI campagna di scavo archeologico a Tifernum Mataurense (Sant'Angelo in Vado - PU) l'Università ha ideato, curato ed attuato il progetto 'Vado per la città antica', concernente un ciclo di attività ed eventi per la valorizzazione dell’area archeologica tifernate, inserito nel programma dell’Estate vadese: 'Aperiterme', 'la Domus del mito tra terra e cielo', 'I lunedì dell'archeologia', 'A lavoro con gli archeologi', 'Facciamo il punto', 'Per un cantiere aperto'. Le iniziative sono state curate e realizzate su base scrupolosamente scientifica con conoscenze e personale universitario, a titolo gratuito e in sinergia con il Comune, che ha atteso agli aspetti organizzativi e logistici
Tifernum Mataurense: un laboratorio tra beni culturali e turismo
No full textLa constatazione della considerevole valenza storico-archeologica del comprensorio di Sant’Angelo in Vado, l'antica Tifernum Mataurense, dell'immenso patrimonio storico-artistico, naturalistico ed eno-gastronomiche dell'area e del conseguente possibile indotto economico e turistico per la città ha spinto l'Università di Macerata, da circa un ventennio impegnata in ricerche archeologiche nel municipio tifernate, a elaborare in sinergia col Comune di Sant'Angelo in Vado, un progetto-laboratorio, che, partendo dalla realtà archeologica ‘militante’, possa creare un efficiente e moderno allestimento dell'area archeologica, come dettagliatamente proposto, una dinamica musealizzazione dei reperti (Museo in quadri) e una comunicazione efficace, innovativa e diversificata, che tenga conto di ‘pubblici’ differenti, anche stranieri, e comprenda gli altri beni culturali storico-artistici, ambientali ed eno-gastronomici.
La finalità è quella di creare un circuito di approfondite conoscenze scientifiche relative ai beni culturali della zona, tra loro sinergicamente collegate, per trasformarle in prodotti di una intelligente promozione turistica ed economica del territorio, effettuata secondo il più moderno approccio del Management dei Beni Culturali
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Arteriomegaly and inflammatory abdominal aortic aneurysm. Case report.
No full textIn this case report inflammatory abdominal aortic aneurysm (IAAA) was superimposed on an arteriomegaly condition complicated by bilateral aneurysm of the common iliac arteries. Obstruction of the right ureter, mild hydronephrosis of the left system and a slight impairment of renal function were also present. Preoperative cellular and humoral immunological parameters were within normal limits while the erythrocyte sedimentation rate (ESR) was elevated (74 mm). Histological analysis showed numerous scattered lymphoid cells or organized in follicles with germinal centers within the adventitial thickening of the IAAA wall. Immunohistochemical analysis on frozen sections demonstrated that dispersed and perivascular lymphoid cells were mainly composed of similar amounts of CD3+/CD4+ and CD3+/CD8+ T lymphocytes. Histological analysis of the common iliac artery aneurysm showed a mild intimal thickening will small aggregates of macrophages. After aneurysm repair all peripheral blood analysis normalized within one month after surgery. The IAAA observed in our patient with arteriomegaly as underlying arterial disease cannot be interpreted as an inflammatory variation of an atherosclerotic aneurysm. The histological pattern of the inflammatory reaction and its resolution after surgery give, in our opinion, more credit to the etiopathogenetic hypothesis of a reaction elicited by an antigen within the arterial wall of the infrarenal aorta which might be enhanced by the lymphatic stasis subsequent to aneurysm compression
- …
