1,963 research outputs found
Physicochemical properties and 3D geostatistical simulations of the Herten and the Descalvado aquifer analogs
No full textThis data set presents a comprehensive characterisation of the sedimentary structures from important groundwater hosting formations in Germany (Herten aquifer analog) and Brazil (Descalvado aquifer analog). Multiple 2-D outcrop faces are described in terms of hydraulic, thermal and chemical properties and interpolated in 3D using stochastic techniques. For each aquifer analog, multiple 3D realisations of the facies heterogeneity are provided using different stochastic simulations settings. These are unique analogue data sets that can be used by the wider community to implement approaches for characterising aquifer formations
Muon session. Overview of the new muon organization/G Mikenberg. Preparation for the MDT PRR/G Herten. Preparation for the mod-0 production in Greece/C Petridou
No full textTreating the patient not just the disease? : Delving deeper into the possible link between affective disorders and coronary heart disease through statistical analysis of a random sample of Maltese people
No full textBackground: Ischemic heart disease is the leading cause of death in Males in Malta and globally. Affective disorders are the commonest psychological problem. This cross-sectional study utilizes a multiple regression model utilizing binary logistic to delve deeper into the link between affective disorders and coronary heart disease and also the link between coronary heart disease and anxiety and depression separately.
Methods: The study was performed in the small Mediterranean island of Malta through the European health interview survey (EHIS), at a national level involving 5500 participants. The response rate attained in the actual field work was 72%. Statistical analysis involved performing chi-squared tests on all contributing variables and retaining those variables that were significant to both diseases. These were then placed in a multiple regression model using forward stepwise binary logistic to retain only the most significant variables.
Results: Age, gender, BMI, diabetes prevalence, depression prevalence, anxiety prevalence, hypertension prevalence, affective disorders( having either anxiety or depression), smoking status, frequency of alcohol intake, and educational level all had a significance of <0.05, some; than less than 0.01. On fitting a multiple regression model, Anxiety (p=0.033), age (p=<0.001), gender (p=<0.001), hypertension (p=0.016) retained their significance in the model. Diabetes could not be analyzed due to power issues.
Conclusion: BMI was not retained in the model having been replaced by associated conditions such as hypertension, together with age and gender as strongly associated risk factors. Anxiety nevertheless retained its independent association with coronary heart disease, in spite of the presence of the other stronger predictors described above.peer-reviewe
The survey and reference assisted assembly of the Octopus vulgaris genome
No full textThe common octopus, Octopus vulgaris, is an active marine predator known for the richness and
plasticity of its behavioral repertoire, and remarkable learning and memory capabilities. Octopus
and other coleoid cephalopods, cuttlefish and squid, possess the largest nervous system among
invertebrates, both for cell counts and body to brain size. O. vulgaris has been at the center of a longtradition
of research into diverse aspects of its biology. To leverage research in this iconic species, we
generated 270 Gb of genomic sequencing data, complementing those available for the only other
sequenced congeneric octopus, Octopus bimaculoides. We show that both genomes are similar in size,
but display different levels of heterozygosity and repeats. Our data give a first quantitative glimpse into
the rate of coding and non-coding regions and support the view that hundreds of novel genes may have
arisen independently despite the close phylogenetic distance. We furthermore describe a referenceguided
assembly and an open genomic resource (CephRes-gdatabase), opening new avenues in the
study of genomic novelties in cephalopods and their biology.sponsorship: We are recognizing the contribution of Drs A. Cole (currently at University of Vienna), N. Tublitz (Oregon University), and C. Di Cristo (University of Sannio and CephRes) for their generous support at an earlier stage of this project. The contribution of the State Key Laboratory of Agricultural Genomics (grant No. 2011DQ782025) to GEM is also appreciated. EAR and OS are supported by a grant from the Austrian Science Fund (FWF): P30686-B29. We thank the COST Action (FA1301) that facilitated the networking initiative underlying this study. Genome browsers are integrated in the CephRes databases-website platform (http://www.cephalopodresearch.org/ceph_gdatab/) based on a bilateral agreement with University of Vienna. This study was supported by BGIShenzhen and by the Association for Cephalopod Research 'CephRes' a no-profit organization. (State Key Laboratory of Agricultural Genomics|2011DQ782025, Austrian Science Fund (FWF)|P30686-B29, COST Action|FA1301, BGIShenzhen, Association for Cephalopod Research 'CephRes' a no-profit organization, Austrian Science Fund (FWF)|P30686)status: Published onlin
Association of Genetic Polymorphisms with Abdominal Aortic Aneurysm in the Processes of Apoptosis, Inflammation, and Cholesterol Metabolism
No full textBackground and Objectives: This study aims to identify the minor allele of the single nucleotide polymorphisms (SNPs) DAB2IP rs7025486, IL6R rs2228145, CDKN2BAS rs10757278, LPA rs3798220, LRP1 rs1466535, and SORT1 rs599839 in order to assess the risk of abdominal aortic aneurysm (AAA) formation and define the linkage among these SNPs. Materials and Methods: A case-control study with AAA patients (AAA group) and non-AAA controls (control group) was carried out in a study population. DNA was isolated from whole blood samples; the SNPs were amplified using PCR and sequenced. Results: In the AAA group of 148 patients, 87.2% of the patients were male, 64.2% had a history of smoking, and 18.2% had relatives with AAA. The mean ± SD of age, BMI, and aneurysmal diameter in the AAA group were 74.8 ± 8.3 years, 27.6 ± 4.6 kg/m2, and 56.2 ± 11.8 mm, respectively. In comparison with 50 non-AAA patients, there was a significantly elevated presence of the SNPs DAB2IP rs7025486[A], CDKN2BAS rs10757278[G], and SORT1 rs599839[G] in the AAA group (p-values 0.040, 0.024, 0.035, respectively), while LPA rs3798220[C] was significantly higher in the control group (p = 0.049). A haplotype investigation showed that the SNPs DAB2IP, CDKN2BAS, and IL6R rs2228145[C] were significantly elevated in the AAA group (p = 0.037, 0.037, and 0.046) with minor allele frequencies (MAF) of 25.5%, 10.6%, and 15.4%, respectively. Only DAB2IP and CDKN2BAS showed significantly higher occurrences of a mutation (p = 0.028 and 0.047). Except for LPA, all SNPs were associated with a large aortic diameter in AAA (p < 0.001). Linkage disequilibrium detection showed that LPA to DAB2IP, to IL6R, to CDKN2BAS, and to LRP1 rs1466535[T] had D’ values of 70.9%, 80.4%, 100%, and 100%, respectively. IL6R to LRP1 and to SORT1 had values for the coefficient of determination (r2) of 3.9% and 2.2%, respectively. Conclusions: In the investigated study population, the SNPs CDKN2BAS rs10757278, LPA rs3798220, SORT1 rs599839, DAB2IP rs7025486, and IL6R rs2228145 were associated with the development of abdominal aortic aneurysms. Individuals with risk factors for atherosclerosis and/or a family history of AAA should be evaluated using genetic analysis
Von den Grenzen einer theologischen Musikästhetik. Eine religionsphilosophische Expansion
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