1,721,119 research outputs found
G. Gioia, La divina filosofia. La Certosa e l'amore di Dio, (Spiritualité n° 19), 1994
No full textSchmitz-Perrin Rudolf. G. Gioia, La divina filosofia. La Certosa e l'amore di Dio, (Spiritualité n° 19), 1994. In: Revue des Sciences Religieuses, tome 69, fascicule 1, 1995. La tradition des logia dans l'Évangile de Jean. pp. 123-124
STUDI DI ESPRESSIONE DI MICRORNA NELLE NEOPLASIE EMATOLOGICHE DEL CANE
Full text linkRecent studies have identified a new class of short noncoding RNAs called microRNAs (miRNA) that are involved in gene expression negative regulation. Until now miRNAs were discovered in a several organisms, such as viruses, protozoa, plants, arthropods, fish, amphibians and mammals. The MicroRNAs constitute about 1-3% of predicted genes in animals genomes, and each miRNA can control hundreds of gene targets. A large number of studies in human medicine have suggested that miRNAs play important roles in innate immune response modulation and they are involved in normal hematopoiesis and haematological malignancies; miRNAs are differentially expressed in hematopoietic lineages and any alteration of these processes is directly associated with a dysregulation of miRNAs. In human the expression profiling of miRNAs serve as biomarkers for hematopoietic tumor classification, diagnosis and prognosis. The frequency and nature of some of these tumors are comparable in dogs and humans, it is possible to hypothesize that the analysis of microRNAs may play an important role also in canine hemato-oncology. The aim of this work was the investigation of the expression profile of a panel of putative miRNAs in dogs with different types of spontaneous lymphoid neoplasms (T-CLL, B-CLL, T Cells Lymphomas, B Cells Lymphomas, Splenic lymphomas). Often to validate a molecular marker in the dog it is difficult to have a sufficient number of clinical samples, for this reason it is necessary to make retrospective studies based on analysis that put to use archival samples, such as tissue formalin-fixed paraffin-embedded (FFPE) or stained smears. It has been reported that miRNA expression profile in FFPE samples correlates well with the corresponding fresh-frozen samples (Xi 2007), on the contrary for the cytological sample smears there is not any methods for the miRNA extraction and analysis. In this work the investigations were conducted both on fresh-frozen and retrospective samples like corresponding FFPE samples and stained smears on which we have standardized a procedure of extraction and analysis of microRNAs. According to the information obtained from literature or from databases, we have selected a panel of putative microRNAs known as ubiquitous or typical of human hematopoietic cells and with conserved sequences in canine genome. The expression levels of the miRNAs selected was determined through real time reverse transcription quantitative PCR (RT-qPCR) in lymphoid tissues of the dog, both healthy and affected by different spontaneous hematopoietic tumors, using TaqMan assays originally designed for the corresponding human microRNAs. Expression data were normalized against the most stable reference miRNAs ranked within a panel of candidate endogenous control (EC) genes through NormFinder and geNorm analysis. The results of this study confirm that also in dogs, as already demonstrated in humans, there is a differential expression of some miRNAs in various hematopoietic malignancies, this suggest the potential utility of miRNAs as a new diagnostic biomarker in the canine hemato-oncology. Moreover with this work makes available a procedure for analysis of microRNAs from cytological slides that allows to obtain comparable data to those obtained from fresh samples, this could be useful for retrospective studies on canine lymphoproliferative disorders, such as lymphoma and leukaemia, where stained smears are often the only archive material available
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
“Assessment of a simplified Runoff Model for the theoretical derivation of the Probability Distribution of floods”.
No full text“Applicabilità di un modello semplificato di deflusso superficiale nell’analisi di frequenza delle piene”
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
SE IL DIALOGO TRA CORTI (INTERNE) RISCHIA DI ESSERE PREGIUDICATO DALLA AMPLISSIMA DISCREZIONALITÀ RICONOSCIUTA AL GIUDICE
No full textSOMMARIO: 1. Premessa - 2. L'ambigua declaratoria di inefficacia contemplata negli articoli 121 e seguenti del c.p.a. - L'articolo 122 c.p.a. e l'amplissima discrezionalità riconosciuta al giudice amministrativo - 3.1 (segue) Cenni sul contrasto con il principio costituzionale della esclusiva soggezione del giudice alla legge - 4. Un'osservazione conclusiva
Il dialogo tra Corti in Europa e l'emersione della proporzionalità amministrativa
No full textL'emersione del principio di proporzionalità nel diritto amministrativo come frutto del dialogo tra Corti: dalla sua origine nell'ordinamento tedesco al suo recepimento nell'ordinamento comunitario e fino al suo arrivo in Italia, come principio distinto da quello di ragionevolezza. L'articolo analizza poi la possibilità che il principio costituisca un vero e proprio criterio operativo per la pubblica Amministrazione e ne individua le applicazioni nella legge sul procedimento amministrativo
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