2,410 research outputs found
La ricerca pittorica di Pietro Finelli tra citazione e riscrittura
No full textIl volume raccoglie saggi di quattro studiosi, di cui due storici dell'arte e due storici del cinema, sul ciclo di pitture recenti realizzate da Pietro Finelli e ispirate al cinema noir statunitense degli anni '40 del Novecento. In particolare il saggio di Gabriella De Marco evidenzia come la ricerca dell'artista sia un esempio di ekphrasis proprio perchè si muove non solo tra ricerca figurativa e cinema ma attinge anche ai rapporti tra arte, filosofia e letteratura
La première del regime parlamentare in Francia. Il discorso d'insediamento del presidente del Consiglio Casimir Périer (18 marzo 1831)
No full textWho are the Russian oligarchs? Recent Developments in the Case Law of the European Court of Justice
No full textpeer reviewedThis Insight examines the developments in the EU restrictive measures against Russia in the aftermath of the full-scale aggression in Ukraine, focusing on the novel "(g) criterion" designed to target Russian businesspersons (often referred to as Russian oligarchs). The analysis illustrates the recent litigation before the General Court, in which targeted individuals seek to annul their designations. It highlights that, compared to previous sanctions practice, the new criterion adopts an innovative sector-based approach, establishing a new link between businesspersons operating in certain economic sectors and vital source of revenue for the Russian government. The Insight further explores the Court's cautious stance on de-listing Russian businesspersons, emphasizing the prudent assessment of evidence and circumvention attempts. Finally, the Insight points to the broad implications of the "(g) criterion" and suggests that the Council holds considerable political discretion in exerting maximum pressure on Russia's business elite, with the ultimate objective of reducing the Kremlin's ability to finance its war
Studio sulla struttura e sul comportamento dinamico di idrogel polisaccaridici per la formulazione di nuovi dispositivi biomedicali
No full textHyadd4-G è un derivato dell’acido ialuronico avente l’ 1÷3% di gruppi carbossilici legati a catene laterali di esadecilammina. L’introduzione di catene laterali esadeciliche sull’acido ialuronico (HA) porta alla formazione di un polisaccaride con nuove proprietà in grado di formare idrogel fisici, stabili a concentrazioni di polimero molto basse, mentre l’ HA nativo forma soluzioni viscose anche a concentrazioni dieci volte maggiori. Il comportamento strutturale e dinamico dell’idrogel Hyadd4-G riguarda diverse scale temporali e spaziali. Il fattore dinamico di struttura, f(Q,t), ottenuto con misure di DLS, è stato usato per ricavare i tempi microscopici caratteristici e le dimensioni della maglia del network. La metodologia del recupero di fluorescenza dopo photobleaching, FRAP, è stata usata per misurare i coefficienti di diffusione di sonde fluorescenti con diverse dimensioni. Le dimensioni idrodinamiche delle sonde, evidenziando un effetto di setaccio degli idrogel con gli esperimenti di FRAP, possono essere comparate con le dimensioni di maglia, δ, degli idrogel Hyadd4-G studiati con DLS. Misure di reologia nel regime viscoelastico lineare hanno mostrato che Hyadd4-G è un gel “soffice” viscoelastico. Tali misure hanno mostrato inoltre un particolare meccanismo di ricostituzione (“recupero di struttura”) dopo la distruzione del network del gel con misure in flusso e l’iniettabilità dell’idrogel è supportata da un pronunciato comportamento di “shear-thinning” sotto una deformazione non-lineare. La tecnica dello scattering dei neutroni ha fornito informazioni sulla microstruttura e sulle proprietà di diffusione dell’acqua nel network. La caratterizzazione dello Hyadd4-G ha mostrato che la formazione del gel è dovuta all’interazione tra le catene laterali idrofobiche che stabilizzano il network 3D con un’architettura di dimensioni nanoscopiche, nonostante il basso grado di sostituzione. Questa rappresentazione fornisce il necessario background per considerare Hyadd4-G come un potenziale nuovo idrogel utilizzabile per trattamenti di malattie osteoarticolari.
Lo xantano e il konjac glucomannano accoppiati forniscono uno dei sistemi di idrogel sinergici maggiormente studiati. Le zone di giunzione che stabilizzano una struttura 3D sono rappresentate da complessi macromolecolari in soluzione formati da catene polisaccaridiche parzialmente depolimerizzate. Le interazioni non-covalnti che stabilizzano la struttura del complesso polisaccaridico causano la distruzione di una struttura ordinata del complesso in soluzione e dell’idrogel. L’introduzione di legami chimici nella struttura 3D dell’idrogel sinergico rimuove questo comportamento, aggiungendo nuove caratteristiche al rigonfiamento e alle proprietà viscoelastiche dell’idrogel. L’utilizzo di epicloridrina come agente reticolante a basso peso molecolare non influisce sulla vitalità di fibroblasti NIH 3T3.Hyadd4-G is a derivatized hyaluronic acid having 1÷3% of the carboxyl groups grafted with a hexadecylic amide side-chains. The introduction of a hexadecyl side chain onto hyaluronic acid (HA) chains yields a polysaccharide with new properties, capable of forming physical hydrogels, stable at very low polymer concentrations, whereas native HA forms viscous solutions at ten times higher concentrations. We addressed the structural and dynamic behavior of Hyadd4-G hydrogels at different time and length scales. Dynamic structural factor, f(Q,t), obtained by DLS, was used to extract the microscopic characteristic times and pore size of the network. Fluorescence recovery after photobleaching methodology, FRAP, was used to measure diffusion coefficients of fluorescent probes with different size. The hydrodynamic coil dimensions of dextrans evidencing a sieving effect of the hydrogels by FRAP experiments can be compared with the mesh size, δ, of Hyadd4-G hydrogels studied by DLS. Rheology measurements in the linear viscoelastic regime show that Hyadd4-G is a soft viscoelastic gel. Rheological measurements showed an unusual self-healing mechanism (structure recovery) after destruction of the gel network in a shear flow and the injectability of the hydrogel is supported by a pronounced shear-thinning behavior under nonlinear deformations. Neutron scattering techniques can provide information about the microstructure and the diffusional properties of water within the pores of the network. Characterization of Hyadd4-G showed that the driving force for its gel-like behavior is the occurrence of hydrophobic interactions involving hydrophobic side-chains stabilizing a 3D-network with nano-sized architecture, despite the low degree of substitution. This picture provides the necessary background to assess Hyadd4-G as one of the potential new hydrogel systems suitable for treatment of osteoarticular diseases.
Xanthan and konjac glucomannan pair provides one of the most studied synergistic hydrogels. The junction zones stabilizing the 3D structure of this gel are present as macromolecular complexes in solution formed by the partially depolymerised polysaccharidic chains. The non-covalent interactions stabilizing the structure of the polysaccharidic complex cause the melting of the ordered structure of the complex in the solution and of the hydrogels. Introduction of chemical cross-links in the 3D structure of the synergistic hydrogel removes this behaviour, adding new features to the swelling and to the viscoelastic properties of the cured hydrogel. The use of epichlorohydrin as low molecular weight cross-linker does not impact on the viability of NIH 3T3 fibroblasts
La ricezione del discorso politico: scatola nera o poliedro «multifaccia»?
No full textCe livre porte sur la mise en place et le fonctionnement des circuits communicatifs et des communautés interprétatives des langages politiques entre XIXe et XXe siècles. En particulier, les contributions de spécialistes italiens (F. Bertoni, I. Veca, R. Camurri, M. Aglietti, E. Fimiani, V. Galimi) et français (L. Jaume, A. Laquièze, J. Hautebert, C. Brice) se focalisent sur la réception du discours politique à la lumière d’une approche méthodologique qui dégage le caractère performatif du discours politique et sa spécificité de «parole en action». Par le biais d’études de cas concernant différents contextes européens (Espagne, France, Italie, Allemagne) ainsi que différents publics (parlementaires, patriotiques, électoraux, national-populistes), les auteurs expérimentent trois voies possibles à l’étude historique des stratégies comunicatives et de la réception du discours politique, puisant à la fois dans la théorie de la littérature, la sociologie de la communication et la stylistique du texte
The mtDNA 15497 G/A polymorphism in cytochrome b in severe obese subjects from Southern Italy
No full textAbstract
BACKGROUND AND AIM:
A large number of mitochondrial DNA (mtDNA) mutations have been implicated in degenerative diseases and aging. The aim of this study was to evaluate whether the 15497 G/A mtDNA polymorphism (G251S) in the cytochrome b subunit of respiratory complex III, which has been associated with obesity-related variables and lipid metabolism in a Japanese population, is associated with severe obesity also in adult Caucasians from southern Italy.
METHODS AND RESULTS:
Unrelated severely obese patients (n = 317; BMI > 40kg/m2) and controls (n = 217; BMI < 25kg/m2) from Southern Italy were genotyped by allelic discrimination TaqMan assay for the 15497 G/A mtDNA polymorphism. In obese patients fasting serum total cholesterol, triglycerides, HDL-cholesterol and glucose were measured enzymatically and sitting blood pressure and heart rate were also collected. Mean levels of total cholesterol, triglycerides and glucose were below the upper reference limit for healthy subjects. Female obese subjects showed lower levels of blood pressure and heart rate and higher levels of HDL cholesterol than male obese patients (P < 0.001). All the control subjects and 315/317 severely obese patients were homozygous for the G allele (wild type), whereas only 2/317, were females homozygous for the A allele.
CONCLUSIONS:
The mtDNA 15497 G/A polymorphism in cytochrome b was present in 0.6% obese subjects, two females whose lipid parameters and BMI were similar to those of the overall group. Therefore, this mutation may appear to contribute in rare instances to severe obesity but does not explain the majority of cases in our population. A more extensive genetic haplogroup characterization is required to identify associations to obesity in Caucasians
The mtDNA 15497 G/A polymorphism in cytochrome b in severe obese subjects from Southern Italy.
No full textBackground and aim: A large number of mitochondrial DNA (mtDNA)
mutations have been implicated in degenerative diseases and aging. The aim of this
study was to evaluate whether the 15497 G/A mtDNA polymorphism (G251S) in the
cytochrome b subunit of respiratory complex III, which has been associated with
obesity-related variables and lipid metabolism in a Japanese population, is
associated with severe obesity also in adult Caucasians from southern Italy.
Methods and results: Unrelated severely obese patients (n Z 317; BMI > 40 kg/m2)
and controls (n Z 217; BMI < 25 kg/m2) from Southern Italy were genotyped by
allelic discrimination TaqMan assay for the 15497 G/A mtDNA polymorphism. In
obese patients fasting serum total cholesterol, triglycerides, HDL-cholesterol and
glucose were measured enzymatically and sitting blood pressure and heart rate
were also collected. Mean levels of total cholesterol, triglycerides and glucose were
below the upper reference limit for healthy subjects. Female obese subjects
showed lower levels of blood pressure and heart rate and higher levels of
HDL cholesterol than male obese patients (P < 0.001). All the control subjects and 315/317 severely obese patients were homozygous for the G allele (wild type),
whereas only 2/317, were females homozygous for the A allele.
Conclusions: The mtDNA 15497 G/A polymorphism in cytochrome b was present in
0.6% obese subjects, two females whose lipid parameters and BMI were similar to
those of the overall group. Therefore, this mutation may appear to contribute in
rare instances to severe obesity but does not explain the majority of cases in our
population. A more extensive genetic haplogroup characterization is required to
identify associations to obesity in Caucasians
Parole in azione. Strategie comunicative e ricezione del discorso politico in Europa fra Otto e Novecento
No full textLa storiografia ha - tranne in rari casi - trascurato il problema dei modi attraverso cui circuiti comunicativi e comunità interpretative prendono forma e agiscono. In particolare, è apparsa ostica a un approccio storico la ricezione del discorso politico, benché la sua specificità rispetto ad altri tipi di discorso (filosofico, letterario) consista proprio nel suo profilo performativo di "parola in azione". Per questo, studiare i canali e le forme della trasmissione del discorso politico, le modalità con cui i destinatari accolgono o respingono messaggi ed enunciati, è fondamentale per comprendere le dinamiche della comunicazione politica. Attraverso case studies relativi a differenti contesti dell'Europa contemporanea, questo volume intende presentare un repertorio di percorsi di ricerca accomunati dall'analisi di testi di intervento politico e dalla ricostruzione delle loro audiences e dei loro dispositivi mediatici
Applications of in-medium chiral dynamics to nuclear structure
No full textA relativistic nuclear energy density functional is developed,
guided by two important features that establish connections with chiral dynamics and the symmetry breaking pattern of low-energy QCD:
a) strong scalar and vector fields related to in-medium changes of
QCD vacuum condensates;
b) the long- and intermediate-range interactions generated by one-and
two-pion exchange,
derived from in-medium chiral perturbation theory, with explicit
inclusion of Delta
excitations. The results are at the same level
of quantitative comparison with data as the best phenomenological
relativistic mean-field models
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