1,721,006 research outputs found
From Genetics to Implantation and Early Fetal Development in Infertile Couples - 24-25 October 2003 - Milan, Italy
No full textOnly severe intrauterine growth restriction (IUGR) alters expression levels of low density lipoprotein receptor-related protein (LRP) and scavenger receptor class B type I (SR-BI)
No full textPlacental fatty acid transport in maternal obesity
No full textPregestational obesity is a significant risk factor for adverse pregnancy outcomes. Maternal obesity is associated with a specific proinflammatory,
endocrine and metabolic phenotype that may lead to higher supply of nutrients to the feto-placental unit and to excessive fetal fat
accumulation. In particular, obesity may influence placental fatty acid (FA) transport in several ways, leading to increased diffusion driving
force across the placenta, and to altered placental development, size and exchange surface area. Animal models show that maternal obesity is
associated with increased expression of specific FA carriers and inflammatory signaling molecules in placental cotyledonary tissue, resulting in
enhanced lipid transfer across the placenta, dislipidemia, fat accumulation and possibly altered development in fetuses. Cell culture experiments
confirmed that inflammatory molecules, adipokines and FA, all significantly altered in obesity, are important regulators of placental lipid
exchange. Expression studies in placentas of obese–diabetic women found a significant increase in FA binding protein-4 expression and in
cellular triglyceride content, resulting in increased triglyceride cord blood concentrations. The expression and activity of carriers involved in
placental lipid transport are influenced by the endocrine, inflammatory and metabolic milieu of obesity, and further studies are needed to
elucidate the strong association between maternal obesity and fetal overgrowth
Preface: from infertility treatment to reproductive health
No full textThe paper introduces the proceedings of the conference 'From infertility treatment to reproductive health', Milano, October 3-4, 2008
Severe intrauterine growth restriction (IUGR) is associated with impaired lipoprotein receptor expression levels in human placenta
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Endothelial lipase is the predominant triglyceride-lipase family member in the human placenta and dysregulated in intrauterine growth-restricted pregnancies but not in gestational diabetes
No full textThe insulin-like growth factor system in mammalian pregnancy - workshop report
No full textSupplement subtitled: 'Trophoblast Research. Placenta: Comparative, Experimental and Clinical Aspects'. Edited by R. Leiser, G. Burton, K. Shiverick, G. Desoye
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