384 research outputs found
Testez, testez, encore et encore les boîtes noires de l'IA.
No full textInterview de Dominique Desbois ua sujet de l'IA en milieu professionnel, dans un ouvrage conçu comme un guide sur le plan juridique pour mieux maîtriser l’IA dans notre environnement proche
Carte de France, offerte par les principales maisons de commerce aux habitants du département de la Sarthe. (Signé : G. Desbois.)
No full textPaving the way to acceptance of Galleria mellonella as a new model insect
No full textFirst paragraph: The larva of the greater wax moth Galleria mellonella is an alternative host used commonly in studies of microbial infection and innate immunity. Indeed, this insect host is often used when quantifying or comparing the virulence of bacterial and fungal pathogens of vertebrates and it has been used successfully to establish the importance of microbial virulence factors and to determine the relative virulence of different isolates of the same species. The recent popularity of G. mellonella as an alternative host system stems from numerous benefits, including the ability to perform experiments at a range of temperatures including human body core temperature; the technical simplicity of establishing infections by various routes such as through feeding, topical application or injection; the convenient size of the insect, which means it is large enough to permit simple injection of inoculums or chemicals but small enough to require little space in the laboratory; the ability to assess the efficacy and toxicity of antimicrobial therapies; and the ease and reliability with which these insects can be sourced in their final instar stage from commercial suppliers. It has also found approval amongst many researchers due to the favourable reproducibility between experiments in the same laboratory. Nevertheless, relatively small variations in susceptibility to infection can occur between batches of larvae from the same supplier and such variation probably arises from factors such as age, size and nutritional status on receipt; conditions encountered during transit to the laboratory; and the presence of any underlying natural infections. These issues are largely uncontrollable when purchasing larvae from a commercial supplier but on reaching the laboratory standardised pre-experimentation storage conditions can improve reproducibility between studies. In recent years the Kavanagh group have raised awareness for the role of a number of variables during storage that require consideration to ensure optimal reproducibility when experimenting with this insect, and factors influencing G. mellonella susceptibility to infections include physical stress, incubation temperature and access to food. In this edition of Virulence, the Kavanagh group report that larvae become increasingly susceptible to infection by pathogens as laboratory storage time increases, highlighting the need to consider this parameter when using the G. mellonella model. Browne et al. elaborate further in the study and relate this observation to a reduction in the total abundance of haemocytes that function in immune defence against pathogens and changes in the relative flux of metabolic pathways. Interestingly, the number of haemocytes after 3 weeks of incubation was approximately half that compared to the population at one week, while qualitative changes in the relative abundance of the various types of haemocytes were also reported. Both these factors probably contribute to reduced immune capacity and thus increased susceptibility to infection.Output Type: Editoria
Ryhiner-Kartensammlung / 12 L' Afrique : dressée sur les relations et nouvelles decouvertes de differens voyageurs, conformes aux observatio.ns astronomiques
No full textmise aujour par le Sr. G. Danet"Avec privilege du roy"Rahmen mit Wappen um die Kart
Conventional and unconventional antimicrobials from fish, marine invertebrates and micro-algae
No full textAll eukaryotic organisms, single-celled or multi-cellular, produce a diverse array of natural anti-infective agents that, in addition to conventional antimicrobial peptides, also include proteins and other molecules often not regarded as part of the innate defences. Examples range from histones, fatty acids, and other structural components of cells to pigments and regulatory proteins. These probably represent very ancient defence factors that have been re-used in new ways during evolution. This review discusses the nature, biological role in host protection and potential biotechnological uses of some of these compounds, focusing on those from fish, marine invertebrates and marine micro-algae
Ryhiner-Kartensammlung / 25 L' Europe : divisée dans ses principaux etats subdivisés en leurs principales provinces : sur les memoires tant anciens que nouveaux : suivant les nouv.les observations astronomiques
No full textmise au jour par le Sr. G. Danet"Avec privilège du roy"Bildrahmen mit WappenNullmeridian: Ferr
Note de lecture : La survie des civilisations. Après 1177 av. J.-C
No full textNotes de lecture parues dans la rubrique "Les livres du mois" de "Le Monde diplomatique".Archaeologist and historian Eric H. Cline is the author of 1177 BC. The Day Civilisation Collapsed, which described the end of the Bronze Age. In this new essay, he continues his examination of ancient civilisations in the eastern Mediterranean and analyses how societies coped with them.Archéologue et historien, Eric H. Cline est l’auteur de 1177 avant J.-C. Le jour où la civilisation s’est effondrée , qui rendait compte de la fin de l’âge du bronze. Avec ce nouvel essai, il analyse, en poursuivant l’examen des civilisations antiques en Méditerranée orientale, comment les sociétés y ont fait face
Surface‐observed and satellite‐retrieved cloudiness compared for the 1983 ISCCP Special Study Area in Europe
No full textInternational audienceA comparison has been undertaken between surface-observed total low-and high-cloud amount and retrievals from METEOSAT radiance data made using the cluster technique of Desbois eli al. (1982). The aim of the study was to establish whether surface-observed cloud information could be usefully exploited to benefit satellite-based cloud retrievals. Observations from 124 surface stations at 1200 UT for the 20-day period from July 22 to August 10, 1983, were compared with retrievals made from METEOSAT radiances measured at 1130 UT. The comparisons for total and low-cloud amount are made for France and southern Britain. The high-cloud amount comparison was limited to 34 stations in southern Britain. The location and time period were selected to coincide with one of the regions designated for special study in the International Satellite Cloud Climatology Project (ISCCP) (Schiffer, 1982). For total cloud amount, 29% of the retrievals were fully in agreement with the surface observations and 64% of differences were within •1 okra (•1 eighth of sky cover). In the case of layer cloud amounts, 64% of the low-cloud amount differences and 50% of the high-cloud amount differences were within •1 okra, although many of these successes (71% in the low-cloud amount) were for cases of totally clear or totally cloudy skies. Surface observations, which offer the only source of accurate low-cloud amount evaluation in any multilayered situation, were found to identify thin cirrus which was not detected by the satellite retrieval and to detect small gaps in cloud decks and small clouds missed by the satellite retrieval. In addition, cloud retrievals in coastal locations seemed to be more successfully accomplished by surface observers than by the satellite retrieval algorithm used here, which does not take into account land-sea partition
JUDOKADANSE / RAY TCHICORAY et son orchestre
No full textComprend : UNE SIMPLE CARTE POSTALE : boléro / G. BERTRET, R. DESBOIS, R. DENONCIN - SUCU-SUCU : cha cha cha / TARATEMO RAJOS - LA PACHANGA : cha cha cha / J. EIGEL, E. DAVIDSON - LA BAMBA / arrgt G. JOUVIN - NOUS LES AMOUREUX : moderato / J. DATIN, M. VIDALIN - BLUE MOON : rock / HART, RODGERS, R. VALAIRE, J. VALMY - LES CROQUETS : cha cha cha / P. DELANOE, H. GIRAUD - OUA-CA-DOU ROCK : charleston / R. LANDY, G. JOUVIN, D. WHITEBnF-Partenariats, Collection sonore - BelieveContient une table des matière
Saleemul Huq (1952-2023), défenseur de la justice climatique
No full texthttps://esprit.presse.fr/actualites/This Bengali climatologist has been a spokesman for those left behind by climate change, from less developed countries and island states. As co-principal author of assessment reports for the Intergovernmental Panel on Climate Change (IPCC), Saleemul Huq was the promoter of the United Nations Sustainable Development Goals on climate action and partnerships. In this way, he played a key role in devising global climate action, for which the IPCC was collectively awarded the Nobel Peace Prize in 2007.Ce climatologue bengali a été le porte-parole des laissés-pour-compte du changement climatique, issus des pays moins développés et des États insulaires. Co-auteur principal de rapports d’évaluation du Groupe d’experts intergouvernemental sur l’évolution du climat (Giec), Saleemul Huq fut le promoteur des objectifs de développement durable des Nations unies sur l’action climatique et les partenariats. Ainsi a-t-il joué un rôle essentiel dans la conception d’une action globale en faveur du climat, pour laquelle le Giec a reçu collectivement le prix Nobel de la paix en 2007
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