1,721,007 research outputs found
Tumore rabdoide del rene ad insorgenza neonatale: descrizione di un caso con osservazioni ultrastrutturali.
No full textDivalent metal-acetate complexes in concentrated aqueous solutions.An X-ray diffraction and N.M.R. spectroscopy study.
No full textIron chelating agents for the treatment of iron overload
No full textThe importance of iron chelators in medicine has significantly increased in recent years. Iron is essential for life but it is also potentially more toxic than other trace elements. This is because we lack effective means to protect human cells against iron overload and because of the role of iron in the generation of free radicals. In order to protect patients from the consequences of iron toxicity, iron chelating agents have been introduced in clinical practice. Unfortunately, the ideal chelator for treating iron overload in humans has not been identified yet. In this paper we examine a few characteristics of iron chelators, with some emphasis on the effects of redox cycling, on absorption mechanisms and on some properties of the pFe. A brief summary is then made of the chelators recently proposed or in development for the treatment of iron overload
An 27Al N.M.R. study on complexes between A13+ and imidazoline-2-one in concentrated aqueous solution.
No full textAl, N M R, structure, aqueous solution
Para-aminosalicylic acid in the treatment of manganese toxicity
No full textManganese excess associated with occupational and environmental
exposure can induce acute effects, with a syndrome known
as manganism, similar for a number of symptoms to Parkinson’s
disease. A possible remedy should be chelation therapy. Paraaminosalicylic
acid (PAS) in its use in China demonstrated effective
in reducing symptoms of manganism. There is evidence of a Nacetylated
metabolite (AcPAS) that seems effective in reducing
manganese levels in brain. Based on these reports we studied the
protonation and the complex formation equilibria of PAS and of
AcPAS with the target metal ion Mn2+. This study has documented
a substantial Mn chelating potential of both ligands. In the actual
case, the metabolism of PAS leads to a derivative with unusual
stronger chelating ability than the parent molecule. It is presumed
that the relatively small molecule Ac-PAS can penetrate across the
blood-to-brain border and exert its Mn2+ mobilizing action intracellularly
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