3,793 research outputs found
Proceedings, 7th International Workshop on Quantum Chromodynamics Theory and Experiment (QCD@Work 2014)
No full textProceedings of the Conference "QCD@work" Dedicated to the study of Quantum Chromodynamics, theory and experiment
Approfondimenti lessicali "La vita delle parole"
No full textLe schede lessicali approfondiscono etimologia, significati, evoluzione, presenza letteraria e legami con altri idiomi delle voci ragguardevoli, fanatica, discrezione, vortice, tacito, gabinetto, ignavo, conflagra, labile, matrone, cetre, formula, intento, profilo, scaglie, catena, creanza, siti, mercato, fondaciThese lexical boxes deepen the etymology, meanings, evolution, literary uses and relationships with other languages of the words "agguardevoli, fanatica, discrezione, vortice, tacito, gabinetto, ignavo, conflagra, labile, matrone, cetre, formula, intento, profilo, scaglie, catena, creanza, siti, mercato, fondaci
A high resolution beam telescope built with double sided silicon strip detectors
No full textA compact and portable beam telescope has been built using four 1.92 x 1.92 cm(2) double sided silicon microstrip detectors with 50 mu m read-out pitch. Tests using 50 GeV pions have shown that the beam position can be defined with a precision of 5 and 7 mu m on the p-side and n-side respectively with an overall detection efficiency of 93.0%
Implementation of low glycemic index diet together with cornstarch in post-gastric bypass hypoglycemia: Two case reports
No full textPost-bariatric hypoglycemia (PBH) is an increasingly recognized long-term complication of bariatric surgery. The nutritional treatment of PBH includes a high-fiber diet and the restriction of soluble and high-glycemic index carbohydrates; however, these measures are not always enough to prevent hypoglycemia. We evaluated the efficacy of uncooked cornstarch, a low-glycemic index carbohydrate characterized by slow intestinal degradation and absorption, in addition to a high-fiber diet, for the treatment of PBH. We report the cases of two young women suffering from severe postprandial and fasting hypoglycemia following Roux-en-Y gastric bypass (RYGB). The patients underwent Continuous Glucose Monitoring (CGM) before and 12−16 weeks after the administration of uncooked cornstarch (respectively 1.25 g/kg b.w. and 1.8 g/kg b.w.) in addition to a high-fiber diet. In both patients, CGM showed more stable glucose levels throughout monitoring, a remarkable reduction of the time spent in hypoglycemia
A TCT and annealing study on Magnetic Czochralski silicon detectors irradiated with neutrons and 24-GeV/c protons
No full textSilicon diodes (pad detectors) were irradiated with 24GeV/c protons at the CERN PS IRRAD1 facility and with neutrons at the TRIGA reactor in Ljubljana (Slovenia). The diodes were realized on Magnetic Czochralski (MCz) grown silicon, of both n- and p-type. After irradiation, an annealing study with CV measurements was performed on 24GeV/c proton irradiated detectors, looking for hints of type inversion after irradiation and during annealing. Other pad detectors were studied using the TCT (transient current technique), to gather information about the field profile in the detector bulk and thus about the effective space charge distribution within it
Accuratezza diagnostica degli ultrasuoni nelle tumefazioni pelviche: considerazioni su 89 casi
No full textStatistical assessment of discriminative features for protein-coding and non coding cross-species conserved sequence elements
No full textBackground: The identification of protein coding elements in sets of mammalian conserved elements is one of the major challenges in the current molecular biology research. Many features have been proposed for automatically distinguishing coding and non coding conserved sequences, making so necessary a systematic statistical assessment of their differences. A comprehensive study should be composed of an association study, i.e. a comparison of the distributions of the features in the two classes, and a prediction study in which the prediction accuracies of classifiers trained on single and groups of features are analyzed, conditionally to the compared species and to the sequence lengths.
Results: In this paper we compared distributions of a set of comparative and non comparative features and evaluated the prediction accuracy of classifiers trained for discriminating sequence elements conserved among human, mouse and rat species. The association study showed that the analyzed features are statistically different in the two classes. In order to study the influence of the sequence lengths on the feature performances, a predictive study was performed on different data sets composed of coding and non coding alignments in equal number and equally long with an ascending average length. We found that the most discriminant feature was a comparative measure indicating the proportion of synonymous nucleotide substitutions per synonymous sites. Moreover, linear discriminant classifiers trained by using comparative features in general outperformed classifiers based on intrinsic ones. Finally, the prediction accuracy of classifiers trained on comparative features increased significantly by adding intrinsic features to the set of input variables, independently on sequence length (Kolmogorov-Smirnov P-value <= 0.05).
Conclusion: We observed distinct and consistent patterns for individual and combined use of comparative and intrinsic classifiers, both with respect to different lengths of sequences/alignments and with respect to error rates in the classification of coding and non-coding elements. In particular, we noted that comparative features tend to be more accurate in the classification of coding sequences - this is likely related to the fact that such features capture deviations from strictly neutral evolution expected as a consequence of the characteristics of the genetic code
Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study
No full text: Drug-induced blockade of the human ether-à-go-go-related gene (hERG) channel is today considered the main cause of cardiotoxicity in postmarketing surveillance. Hence, several ligand-based approaches were developed in the last years and are currently employed in the early stages of a drug discovery process for in silico cardiac safety assessment of drug candidates. Herein, we present the first structure-based classifiers able to discern hERG binders from nonbinders. LASSO regularized support vector machines were applied to integrate docking scores and protein-ligand interaction fingerprints. A total of 396 models were trained and validated based on: (i) high-quality experimental bioactivity information returned by 8337 curated compounds extracted from ChEMBL (version 25) and (ii) structural predictor data. Molecular docking simulations were performed using GLIDE and GOLD software programs and four different hERG structural models, namely, the recently published structures obtained by cryoelectron microscopy (PDB codes: 5VA1 and 7CN1) and two published homology models selected for comparison. Interestingly, some classifiers return performances comparable to ligand-based models in terms of area under the ROC curve (AUCMAX = 0.86 ± 0.01) and negative predictive values (NPVMAX = 0.81 ± 0.01), thus putting forward the herein proposed computational workflow as a valuable tool for predicting hERG-related cardiotoxicity without the limitations of ligand-based models, typically affected by low interpretability and a limited applicability domain. From a methodological point of view, our study represents the first example of a successful integration of docking scores and protein-ligand interaction fingerprints (IFs) through a support vector machine (SVM) LASSO regularized strategy. Finally, the study highlights the importance of using hERG structural models accounting for ligand-induced fit effects and allowed us to select the best-performing protein conformation (made available in the Supporting Information, SI) to be employed for a reliable structure-based prediction of hERG-related cardiotoxicity
QCD@Work 2018 - International Workshop on Quantum Chromodynamics - Theory and Experiment
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