1,721,274 research outputs found
Nord ed Europa. Identità scandinava e rapporti culturali con il continente nel corso dei secoli. The North and Europe. Scandinavian Identity and Cultural Relations with the Continent through the Centuries. Atti del Convegno Internazionale di Studi, Genova, 25-27 Settembre 2003.
No full textThis paper examines the different attitudes of Nordic linguists and scholars towards
foreign words through the centuries. It has been included in the proceedings of an
International Congress of Scandianvian Studies (“The North and Europe.
Scandinavian Identity and Cultural Relations with the Continent through the
Centuries”) that the author himself organized 2003 in collaboration with Gianna
Chiesa Isnardi. The Congress had an interdisciplinary character and was open to
various themes and disciplines (from fiction to the arts, from history to the theatre,
from religion to anthropology and so on – see Table of contents). The author is also
editor of the proceedings
36. Scherri (G.), Chiesa e Sinagoga nelle opere di Origene
No full textNautin Pierre. 36. Scherri (G.), Chiesa e Sinagoga nelle opere di Origene. In: Revue des Études Grecques, tome 97, fascicule 462-464, Juillet-décembre 1984. p. 583
Recombinant apolipoprotein A-IMilano: a novel agent for the induction of regression of atherosclerotic plaques
No full textApolipoprotein (apo) A-I, because of its anti-atherogenic properties, provides a potentially powerful approach to the management of vascular diseases. In the clinic, patients with low high density lipoproteins (HDL)/apoA-I are at dramatically increased risk of coronary disease, the opposite being true for individuals with high HDL Drug studies, e.g., the VA-HIT trial with gemfibrozil, clearly associated a reduced risk of events with raised HDL-cholesterolemia. A number of animal studies have shown that the infusion of apoA-I containing synthetic HDL can inhibit atherosclerosis progression in experimental animals, being also able to stimulate reverse cholesterol transport in humans. Recently, high interest has been devoted to a molecular variant of apoA-I, apoA-I(Milano) (apoA-I(M)), characterized by a Cys for Arg substitution and formation of apoA-I(M)/A-I(M) dimers. These latter are characterized by a prolonged permanence in plasma and a more effective cholesterol removing function, which may offer an improved approach to the therapeutic management of arterial disease. Aside from a number of clinical studies on human apoA-I(M) carriers, all indicating a clear protection from cardiovascular disease in spite of markedly reduced HDL levels, animal investigations have provided definite indication as to the potential of apoA-I(M) infusion to directly reduce the extent of atherosclerotic plaques. In addition to the well known powerful cholesterol effluxing capacity of apoA-I(M), fibrinolytic properties and possibly antioxidant/vasodilator mechanisms seem to be in play. Ongoing clinical studies will provide final indication as to the potential of this new therapeutic approach
Apolipoprotein A-I(Milano): current perspectives.
No full textPURPOSE OF REVIEW: Strategies to increase HDL are among the major targets of clinical research in atherosclerosis prevention. The mutant apolipoprotein A-I(Milano) has been associated with a reduced incidence of coronary disease in carriers. Furthermore, recombinant apolipoprotein A-I(Milano) has displayed remarkable atheroprotective activities and the possibility of directly reducing the burden of atherosclerosis in experimental models. This review is aimed at providing an update on the experimental studies in which apolipoprotein A-I(Milano), produced as a recombinant protein, has displayed important effects in the treatment of vascular diseases. RECENT FINDINGS: In the past year, two reports have appeared, indicating that a single-dose administration of recombinant apolipoprotein A-I(Milano) dimers formulated into liposomes can reduce atheromas in models such as the apolipoprotein E-deficient mice and a rabbit model of carotid focal lesion, in which a direct 90 min infusion of the product reduced atheroma up to 30%. This finding was associated with an increase in HDL free cholesterol and the permanence of the recombinant product in the lesion for over 72 h. SUMMARY: Recombinant apolipoprotein A-I(Milano), formulated as synthetic HDL with phospholipids, appears to exert a direct removing effect on arterial cholesterol. This is well evident in experimental animals and, more recently in clinical findings, as indicated by a dramatic increase in HDL free cholesterol after the infusion of different doses of the agent. As the product appears to be well tolerated and non-immunogenic, ongoing phase II studies in patients are being awaited with interest to obtain a 'proof of principle' for 'HDL therapy'
Use of recombinant apolipoproteins in vascular diseases: the case of apoA-I
No full textApolipoprotein (apo) A-I, because of its anti-atherogenic properties, represents a powerful approach to the management of vascular diseases. Infusion of apoA-I-containing synthetic high-density lipoprotein (HDL) inhibits atherosclerosis progression or prevents restenosis in experimental animals, and apoA-I liposomes are capable of stimulating reverse cholesterol transport in humans. Moreover, many experimental studies have been conducted with a molecular variant of apoA-I, apoA-I(Milano), characterized by a prolonged residence time in plasma and improved function, which may offer an even better approach to the therapeutic handling of arterial disease
Characterization of commercial antibodies for use in high resolution apo(a) phenotyping by immunoblot analysis
No full textHigh resolution apo(a) phenotyping has been used in conjunction with apo(a) genotyping to elucidate underlying mechanisms of plasma lipoprotein(a) (Lp(a)) level control. With increasing interest in this field more laboratories are now establishing such methods. High resolution apo(a) phenotyping has previously been reported with in-house monoclonal antibodies. Here the effective use of a commercially available monoclonal antibody is demonstrated. Two primary antibodies were compared and apo(a) isoform analysis was performed using an immunobloltting method. When equal quantities of Lp(a) were loaded approximately equal signal intensities were obtained, irrespective of apo(a) isoform size. Serial dilutions of samples with known Lp(a) level and a single expressing apo(a) isoform were used to determine the detection limit of the system. With both monoclonals it was possible to detect 0.05 mg/dl Lp(a)
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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