353 research outputs found
Alien Registration- Chaffey, Ethel G. (Eastport, Washington County)
No full texthttps://digitalmaine.com/alien_docs/1675/thumbnail.jp
Molecular pharmacological characterisation of recombinant and native NR2B- and NR3B- containing NMDA receptors
No full textNMDA receptors are ionotropic, glutamate receptors which mediate fast excitatory transmissions within the central nervous system. They form tetrameric or pentameric heterologous complexes from seven NMDA receptor subunits NRl, NR2A-D and NR3A-B which each convey distinct expression patterns, functional and pharmacological properties to the receptor complex. Due to its involvement in excitatory transmission, over-excitation of the NMDA receptor, particularly the NR2B subunit, has been the focus of pharmaceutical therapeutic targeting for neurodegenerative conditions and chronic pain. This thesis discusses the potential importance and clinical effectiveness of targeting NMDA receptors and the difficulties in drag development arising from the receptor's heteromeric nature. The work herein focuses on the pharmacological characterisation of two novel NR2B-selective antagonists Compound A and Compound B， the physiological and pharmacological effects of NR3 subunit inclusion in the NMDA receptor complex, and the modifications of NMDA receptor physiology and subunit expression during chronic pain states. This research provides novel evidence to suggest that Compound A and Compound В bind with a high selectivity and affinity towards NR1/NR2B containing receptors. It provides novel evidence for a differential cytoprotective effect of the NR3 subunits showing significant cytoprotection in NR1/NR2B, but not NR1/NR2A, receptors and shows that NR3B inclusion in the receptor can differentially modulate the binding affinities ofNR2B-selective antagonists. This study also shows evidence for increased activity of spinal and supra-spinal NR2B-containmg receptors indicating NMDA receptor modulation and involvement in a chronic pain model
Digital Business & E-Commerce Management: Strategy Implementation and Practice, 6/E.
No full textThis text offers a comprehensive introduction to the theory and practice of e-business and e-commerce management. The author, Dave Chaffey, brings his trademarks of authority, clarity of expression and teaching expertise to bear on a subject in which he actively lectures and consults. Popular for its cutting-edge and contemporary coverage, this text offers an international approach and a good balance between the technical and managerial topics of central importance to developing an understanding of this subject. Developed for students studying e-business or e-commerce at undergraduate or postgraduate level, and also used by many business managers, this is the essential text to keep pace with technology, strategy and implementation
Digital Business and E-Commerce Management : Strategy, Implementation and Practice
No full textThis text offers a comprehensive introduction to the theory and practice of e-business and e-commerce management. The author, Dave Chaffey, brings his trademarks of authority, clarity of expression and teaching expertise to bear on a subject in which he actively lectures and consults. Popular for its cutting edge and contemporary coverage, this text offers an international approach and a good balance between the technical and managerial topics of central importance to developing an understanding of this subject. Developed for students studying e-business or e-commerce at undergraduate or postgraduate level, and also used by many business managers, this is the essential text to keep pace with technology, strategy and implementation.xxxi+680p.;19,5x26,5c
Protection and Pole Voltage Rebalancing for Pole-to-ground Faults in Symmetrical Monopolar HVDC Grids
No full textPole rebalancing in symmetrical monopolar HVDC grids is
necessary to remove pole imbalances resulting from pole-toground
faults. For selective protection employing DC circuit
breakers, pole rebalancing considering backup protection operation
in case of breaker failure has until now not been studied.
This paper proposes fault clearing and post-fault restoration sequences
including pole rebalancing to deal with DC-side faults,
considering both primary and backup protection operations.
The performance of the proposed sequences and the impact of
the key breaker parameters on pole rebalancing are investigated
in a four-terminal test system using PSCAD/EMTDC.status: Publishe
Descargar libros en línea ebooks Digital Marketing (6th Edition)
No full textRead Or Download Digital Marketing (6th Edition) Full Books By by {"isAjaxInProgress_B002BLVBHM":"0","isAjaxComplete_B002BLVBHM":"0"} Dave Chaffey (Author) › Visit Amazon's Dave Chaffey Page Find all the books, read about the author, and more. See search results for this author Are you an author? Learn about Author Central Dave Chaffey (Author), Fiona Ellis-Chadwick (Author)
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Beyond HRV: Analysis of ECG Signals Using Attractor Reconstruction // Accompanying data
No full textThis data accompanies the figures and results in the following paper:Lyle, J. V., Charlton, P. H., Bonet-Luz, E., Chaffey, G., Christie, M., Nandi, M., and Aston, P. J. 'Beyond HRV: Analysis of ECG Signals Using Attractor Reconstruction'. In Computing in Cardiology (Rennes, France, 2017), vol. 44.Further details are given in the README.txt file.</p
Living star polymer formation (RAFT) studied via electrospray ionization mass spectrometry
No full textA mass spectrometry analysis has been performed on complex architecture polymeric material produced during reversible addition fragmentation chain transfer (RAFT) polymerizations yielding star polymers. Para-acetoxystyrene (AcOSty) has been polymerized at 60 °C, using azobisisobutyronitrile (AIBN) as the thermally decomposing initiator, in the presence of the R-group approach tetrafunctional RAFT agent (1,2,4,5-tetrakis-(2-phenyl-thioacetyl- sulfanylmethyl)-benzene). In addition to ideal star material, a variety of products unique to this mode of polymerization have been identified. These include star-star couples, stars terminated with initiator fragments, star-star couples terminated with initiator fragments and linear polymers, supporting the notion that these species are responsible for the structured molecular-weight distributions measured for these systems when analyzed via gel permeation chromatography. The analysis begins with a study of AcOSty polymerizing (i) in the absence of any mediating agent and (ii) in the presence of a monofunctional RAFT agent, revealing the mode of termination of propagating poly(AcOSty) radicals as combination and that some ionization biases exist among variants of poly (AcOSty). The interpretation of the mass spectrometry data has been aided by a novel kinetic model of star polymerizations, allowing the rationalization of experimental observations with theoretical expectations. © 2008 Wiley Periodicals, Inc
Living star polymer formation: Detailed assessment of poly(acrylate) radical reaction pathways via ESI-MS
No full textThe generation of star polymers via living polymerization protocols is well documented; however, the impact of midchain radicals (MCRs) on the precise formation pathways under operation in living acrylate star polymerizations is still poorly understood. In the present study, electrospray ionization-mass spectrometry (ESI-MS) technology has been applied to map the products generated in R-group approach reversible addition fragmentation chain transfer (RAFT) methyl acrylate (MA) star polymerizations in order to gain insight into the precise formation pathways under operation in such systems. The polymerizations were conducted at 65°C using the tetrafunctional RAFT agent 1,2,4,5-tetrakis(2-phenylthioacetylsulfanylmethyl)benzene and 2,2′-azobis(isobutyronitrile) (AIBN) as the thermally decomposing initiator. Initiator fragment derived linear chains, ideal stars, star-star couples, and other terminated star products formed as a result of combination and disproportionation reactions were successfully imaged. Additionally, MCR derived products that lie outside of the conventional R-group approach RAFT star polymerization mechanistic scheme were identified. Products associated with termination reactions involving intermolecularly formed MCRs on star arms and linear chains were observed; specifically, structures formed from MCR termination with propagating stars or radical carrying star cores, or with initiator fragments or propagating initiator derived linear chains. Additionally, structures produced via repropagation of intermolecularly formed MCRs on star arms were also identified. The products generated from MCR-derived reaction pathways were imaged from a degree of polymerization (DPn) as low as one, indicating that MCRs can form upon molecules carrying only a single monomer unit. © 2008 American Chemical Society
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