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SULODEXIDE FOR USE IN THE TREATMENT OF PATHOLOGIES WHEREIN METALLOPROTEINASES ARE INVOLVED
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Rifamycin derivatives
No full textRifamycin derivs., such as I [R is hydrogen or acetyl R1 and R2 are independently selected from the group consisting of hydrogen, ( C1-4) alkyl, benzyloxy, mono- and di-(C1-3) alkylamino-(C1-4)alkyl, (C1-3)alkoxy, (C1-4) alkyl, hydroxy-Me, hydroxy-(C2-4)-alkyl, and nitro or R1R2 taken together with two consecutive carbon atoms of the pyridine nucleus form a benzene ring optionally substituted by one or two Me or Et groups and R3 is hydroxyalkyl (C1-4)], were prepd. for use in antibacterial pharmaceutical compns. The prepd. rifamycin derivs. were claimed for use in the prevention, treatment or amelioration of bacterial overgrowth in a patient suffering from a bowel related disorder, such as irritable bowel syndrome, travelers' diarrhea, small intestinal bacterial overgrowth, Crohn's disease, chronic pancreatitis, pancreatic insufficiency, hepatic encephalopathy, diverticulitis, enteritis or colitis. These rifamycin derivs. may be used optionally in combination with one or more addnl. antibiotics, such as rifamycin, or rifaximin. Thus, rifamycin deriv. I [R = COMe, R1 = 4-Me, R2 = H, R3 = CH2OH] was prepd. via a cyclocondensation reaction of the corresponding cyclic acetal II with 2-amino-4-methylpyridine. The cyclic acetal II was prepd. by a fermn. process mediated by Nocardia mediterranea. The prepd. rifamycin derivs. were evaluated in vitro for antibacterial activity against a panel of pathogenic bacterium, such as E. coli (ATCC 25922), P. aeruginosa (ATCC 27853) and E. faecalis (ATCC 259212). Pharmaceutical formulations for the delivery of these rifamycin derivs. were presented
The structure–property relationship of four crystal forms of rifaximin
No full textThe crystal structures of four crystal forms of rifaximin, named a, b, d and e, have been elucidated by
a combination of single crystal and powder diffraction experiments with synchrotron and X-ray
sources. The crystal structures of the d and e forms have been determined from powder diffraction
data alone. Hot stage microscopy has also been of paramount importance in the understanding of the
b -> a conversion process
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Mucoadhesive xyloglucan-containing formulations for medical devices and pharmaceutical formulations
No full textAppropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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