3,178 research outputs found
Resting state cortical electroencephalographic rhythms in covert hepatic encephalopathy and Alzheimer's disease
No full textPatients suffering from prodromal (i.e., amnestic mild cognitive impairment, aMCI) and overt Alzheimer's disease (AD) show abnormal cortical sources of resting state electroencephalographic (EEG) rhythms. Here we tested the hypothesis that these sources show extensive abnormalities in liver cirrhosis (LC) patients with a cognitive impairment due to covert and diffuse hepatic encephalopathy (CHE). EEG activity was recorded in 64 LC (including 21 CHE), 21 aMCI, 21 AD, and 21 cognitively intact (Nold) subjects. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). EEG cortical sources were estimated by LORETA. Widespread sources of theta (all but frontal), alpha 1 (all but occipital), and alpha 2 (parietal, temporal) rhythms were higher in amplitude in all LC patients than in the Nold subjects. In these LC patients, the activity of central, parietal, and temporal theta sources correlated negatively, and parietal and temporal alpha 2 sources correlated positively with an index of global cognitive status. Finally, widespread theta (all but frontal) and alpha 1 (all but occipital) sources showed higher activity in the sub-group of LC patients with CHE than in the patients with aMCI or AD. These results unveiled the larger spatial-frequency abnormalities of the resting state EEG sources in the CHE compared to the AD condition
Commento critico. Fonti
No full textPagine scritte da Carlo Lanfossi: 15-16, 17-20, 34-41, 51-53, 61-67, 76-77, 79-82, 92-104
Mutational and expression analysis of ELIP1 and ELIP2 in Arabidopsis thaliana
No full textCasazza AP, Rossini S, Rosso MG, Soave C. Mutational and expression analysis of ELIP1 and ELIP2 in Arabidopsis thaliana. Plant Molecular Biology. 2005;58(1):41-51.Plants exposed to photoinhibitory conditions respond by accumulation of the early light-induced proteins (ELIPs) with a potential photoprotective function. In Arabidopsis thaliana two genes (Elip1 and Elip2) encode for two ELIP proteins: evidence exists that the two genes are differentially regulated but their precise function is unclear. Mutants null for one or the other Elip gene can help in elucidating ELIPs role and here we describe the expression profile of ELIP1 and ELIP2, and the phenotype of such null mutants. Both ELIPs accumulate during greening of etiolated seedlings and in mature plants the transcripts fluctuate diurnally without protein accumulation. Steady-state transcript level of both genes increases in response to high light with transcription of Elip1 much more sensitive than that of Elip2 to increasing irradiation at 22 degrees C. At 4 degrees C instead Elip2 is strongly transcribed even at growing light. Furthermore, only ELIP1 accumulates under high light at 22 degrees C while both proteins accumulate at 4 degrees C. These results indicate the existence of a differential regulation of ELIPs expression in response to light or chilling stress with mechanisms active either at transcriptional and post-transcriptional level. Phenotypically, the mutants behave as the wild type as far as sensitivity to light- or light and cold-induced short-term photoinhibition, while both ELIPs are necessary to ensure a high rate of chlorophyll accumulation during deetiolation in continuous high light
Genotype (Cystatin c) and EEG phenotype in Alzheimer disease and mild cognitive impairment: a multicentric study.
No full textPrevious findings demonstrated that haplotype B of CST3, the gene coding for cystatin C, is a recessive risk factor for late-onset Alzheimer's disease (AD; Finckh, U., von der Kammer, H., Velden, J., Michel, T., Andresen, B., Deng, A., Zhang, J., Muller-Thomsen, T., Zuchowski, K., Menzer, G., Mann, U., Papassotiropoulos, A., Henn, R., Zurdel, J., Hoist, F., Benussi, L., Stoppe, G., Reiss, J., Miserez, A.R., Staehelin, H.B., Rebeck, G.W., Hyman, B.T., Binetti, G., Hock, C., Growdon, J.H., Nitsch, R.M., 2000. Genetic association of the cystatin C gene with late-onset Alzheimer disease. Arch. Neurol. 57, 1579-1583). In the present multicentric electroencephalographic (EEG) study, we analyzed the effects of CST3 haplotypes on resting cortical rhythmicity in subjects with AD and mild cognitive impairment (MCI) with the hypothesis that sources of resting EEG rhythms are more impaired in carriers of the CST3 B haplotype than non-carriers. We enrolled a population of 84 MCI subjects (42% with the B haplotype) and 65 AD patients (40% with the B haplotype). Resting eyes-closed EEG data were recorded in all subjects. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography (LORETA). Results showed that the amplitude of alpha 1 (parietal, occipital, temporal areas) and alpha 2 (occipital area) was statistically lower in CST3 B carriers than noncarriers (P < 0.01). Whereas there was a trend towards statistical significance that amplitude of occipital delta sources was stronger in CST3 B carriers than in non-carriers. This was true for both MCI and AD subjects. The present findings represent the first demonstration of relationships between the AD genetic risk factor CST3 B and global neurophysiological phenotype (i.e., cortical delta and alpha rhythmicity) in MCI and AD subjects, promting future genotype - EEG phenotype studies for the early prediction of AD conversion in individual MCI subjects. (c) 2005 Elsevier Inc. All rights reserved
Optimization of an Independent Component Analysis approach for artifact identification and removal in MEG signals
No full textRossini Farming Company Research Final Report
No full textR: RFC Avena Ranch Zin 1990-96B: Bronco Tables 1995 & 1996 Hawk Crest 1995-1997R: Rossini Farming 1996 Final ReportBox 5 M-S 16; Box 5 M-S 19; Box 2 C-E 28; Box 2 C-E 29; Box 7 T-W7B: Bronco 1998 - 1999 ppl.B: Bronco Tables 1997TC: Treessentials Rossini 19971993_36; 1995_22; 1996_26; 1997_19; 1998_2
“La réclame recommence, elle mûrit la solennité”: critica musicale e recezione della versione orchestrale della Petite messe solennelle
No full textSHEPHERD SCHOOL CHAMBER ORCHESTRA LARRY RACHLEFF, conductor Sunday, October 3, 1993 8:00 p.m. Stude Concert Hall
No full textPlaylist: Overture to L'Italiana in Algeri -- Gioacchino Rossini (1792-1868) / Piano concerto no. 1 in G minor, op. 25 -- Felix Mendelssohn-Bartholdy (1809-1847) / Symphony no. 1 in C major, op. 21 -- Ludwig van Beethoven (1770-1827)
Fig. 4. – Sinningia hoehnei Chautems. A.P. Fontana & Rossini. A in Three new species of Sinningia (Gesneriaceae) endemic to Espírito Santo, Brazil
No full textFig. 4. – Sinningia hoehnei Chautems. A.P. Fontana & Rossini. A. Habit; B. Lateral view of flower with calyx; C. Calyx and style; D. Dorsal view of nectary glands; E. Schematic arrangement of the nectary glands; F. Dorsal surface of anthers; G. Ventral surface of anthers; H. Fruit split open. [Kollmann & Fontana 12720, MBML] [Drawing: J. Rossini
Functional topography of the secondary somatosensory cortex for nonpainful and painful stimulation of median and tibial nerve: an fMRI study.
No full textFunctional magnetic resonance imaging (fMRI) was used to study the cortical activity of the bilateral secondary somatosensory cortex (SII) during nonpainful (motor threshold) and painful electrical stimulation of median and tibial nerves. fMRI recordings were performed in eight normal young adults. The aim was at evaluating the working hypothesis of a spatial segregation of nonpainful and painful populations not only in the bhandQ representation of SII [Ferretti, A., Babiloni, C., Del Gratta, C., Caulo, M., Tartaro, A., Bonomo, L., Rossini, P.M., Romani, G.L., 2003. Functional topography of the secondary somatosensory cortex for nonpainful and painful stimuli: an fMRI study. NeuroImage 20, 1625– 1638.] but also in its bfootQ representation. Results showed that, in both bhandQ and bfootQ representations of bilateral SII, the activity elicited by the painful stimulation was localized more posteriorly with respect to that elicited by the nonpainful stimulation. A fine spatial analysis of the SII responses revealed a clear somatotopic organization in the bilateral SII subregion especially reactive to the nonpainful stimuli (i.e., segregation of the hand and foot representations). In contrast, it was not possible to disentangle the bhandQ and bfootQ representations of SII for painful stimuli. These results extended to the SII bfootQ representation previous evidence of a spatial segregation in the SII bhandQ representation of subregions for the painful and nonpainful stimuli. Furthermore, they suggest that noxious information is not somatotopically represented in human bilateral SII, at least as inferred from fMRI data at 1.5 T
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