1,818,626 research outputs found

    Evolution of the G+C content frontier in the rat cytomegalovirus genome

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    Within the 230138 bp of the rat cytomegalovirus (RCMV) genome, the G+C content changes abruptly at position 142644, constituting a G+C content frontier. To the left of this point, overall G+C content is 69.2%, and to the right it is only 47.6%. A region of extremely low G+C content (33.8%) is found in the 5 kb immediately to the right of the frontier, in which there are no predicted coding sequences. To the right of position 147501, the G+C content rises and predicted coding sequences reappear. However, these genes are much shorter (average 848bp, 50% G+C) than those in the left two-thirds of the genome (average 1462bp, 70% G+C). Whole genome alignment of several viruses indicates that the initial ultra-low G+C region appeared in the common ancestor of the genera Cytomegalovirus and Muromegalovirus, and that the lowering of G+C in the right third has been a subsequent process in the lineage leading to RCMV. The left two-thirds of RCMV has stop codon occurrences at 67.5% of their expected level, based on a modified Markov chain model of stop codon distribution, and the corresponding figure for the right third is 78%. Therefore, despite heavy mutation pressure, selective constraint has operated in the right third of the RCMV genome to maintain a degree of gene length unusual for such low G+C sequences

    G. C. Ellis

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    "Private G.C Ellis. H Q Company. 8th Aust Inf Bn. Pioneer Platoon."Private G. C. Ellis. Headquarters Company. 8th Australian Infantry Battalion, Pioneer Platoon

    Letter from G. C. Baugham

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    Letter from G. C. Baugham, sending in report on former students

    Vermischte Gedichte / von G. C. Jürgens

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    VERMISCHTE GEDICHTE / VON G. C. JÜRGENS Vermischte Gedichte / von G. C. Jürgens (1) Cover (1) Titelseite (2) Anstatt der Vorrede (3) Inhalt (5) An die Günstigen - Der Harzer Leben (7) Für die Kinder des Herrn P. M. - Meine liebsten Phantasien (20) Die rasselnde Mühle - Die Quellen (33) Graf Felsberg. Ballade (48) Lied vom kranken Jüngling - Der reiche Landmann (60) Ueber Goethes Faust - Mein Schwert (71

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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