1,720,969 research outputs found
Esthesioneuroblastoma : a general review of the cases published since the discovery of the tumour in 1924
No full textEsthesioneuroblastoma (ENB) arises from the neuroepithelium in the olfactory rim of the nasal cavity. It accounts for about 3% of all intranasal tumours. Reviews since the first description by Berger and Luc in 1924 never reported more than a hundred cases, stressing the rarity of the tumour. However, a thorough literature review revealed a total of 945 reported cases. In our search we found a total of 1,457 cases chronicled in the literature of which perhaps 487 were cited in more than one paper, bringing the total of reported cases to 945. Author cases accounted for 198 and therefore collaborative efforts accounted for 747 cases. Sex distribution was 53.36% male and 46.64% female. Kadish classification was applied to 553 cases revealing 103 (18.29%) class A cases, 182 (32.33%) class B and 278 (49.38%) class C cases. This distribution was generally stable through the decades. Treatment could be classified in 898 cases. It consisted of surgery alone in 25.17% (226 cases), radiotherapy alone in 18.37% (165 cases), combined surgery and radiotherapy in 43.21% (388 cases) and chemotherapy in 13.2% (119 cases), followed in 11 cases (1.22%) by bone marrow transplant. In the reported cases an overall follow up could be evaluated in 477 cases, while in only 234 cases a five-year follow up was done. The outcome was 68.38% alive and disease free, 12.82% alive with disease and 18.80% dead. From these 20.51% had surgery only, 11.11% radiotherapy and 68.38% combined surgery and radiotherapy. The best survival rates were obtained by combined therapy (72.5% vs. 62.5% surgery alone and 53.85% radiotherapy alone). Death rates were highest after radiotherapy alone (30.77% versus 18.75% in combined therapy and 12.50% after surgery alone). In conclusion, ENB is a rare but not exceptional tumour. It is best treated with combined surgery and radiotherapy. Unfortunately early diagnosis is still uncommon and no significant changes to the proportions of Kadish classes at first diagnosis have been noted in recent decades. A greater awareness of the tumour and earlier diagnosis seems the major focus for future research
Carcinoma of the vocal cord. Results after subperichondral cordectomy
No full textThe clinical outcome of 110 patients operated upon by subperichondral cordectomy between 1982 and 1992 for T1s/T1a, NO, MO carcinomas of the vocal cord has been evaluated in this longitudinal epidemiological study. Patients have been followed up until the end of 1993 by examinations done once a month (first year), every three months (years 2 to 4), every six months (years 5 to 8), and then once a year. Life-tables have been computed according to Kaplan and Meier and raw survival has been 90.0%. Considering only the mortality due to any type of neoplastic disease, the survival reached 93.6%. Finally, considering only deaths due to recurrences or metastases of the primary tumor, the survival rate was 95.5%. Mortality after the first recurrence was 27.3%, after a second recurrence 50.0%. A correlation between number of cigarettes smoked and the risk of recurrence of the tumor could be observed (p < 0.01), while gross appearance and histologic grading of the vocal cord carcinoma proved to be uncorrelated with the risk of recurrences
Prognostic value of Delphian lymph node in T1b glottic carcinoma
No full textBackground: The published papers concerning Delphian lymph node (DN) involvement in laryngeal tumours generally consider advanced laryngeal and hypopharyngeal cancer. We investigated the role of DN in a selected group of patients with T1b glottic squamous cell carcinoma. Materials and Methods: The study involved 53 patients with T1b glottic squamous cell carcinoma who underwent horizontal glottectomy. DN was isolated in 46 (86.8%). Histological evaluation of the isolated nodes revealed the presence of metastases in three cases (6.5%). Results: Forty-six of the 53 patients (86.8%) are still alive and disease-free; four (7.5%) died because of their disease and three (5.7%) because of unrelated causes. The 3- and 5-year overall survival was, respectively, 94.3% and 90.6%. Both the 3- and 5-year disease-free survival was 92.5%. Two of the three patients with a metastatic DN died because of a recurrence: laterocervical lymph node metastases in one case and parastomal recurrence in the other. The frequency of local relapse was at the threshold of significance in the patients with a positive DN (p=0.0540). Of the four patients who died of their disease, two were DN-positive. Mortality was statistically higher in the DN-positive patients (p=0.0166). Conclusion: The presence of DN metastases was statistically associated with recurrence and overall survival in T1b glottic cancer
PCNA--a cell proliferation marker in vocal chord cancer. Part I: Premalignant laryngeal lesions
No full textLaryngeal hyperkeratotic lesions can progress to fully developed malignant carcinoma in some cases. These premalignant lesions are proliferative disorders whose potential for further tumour progression is perhaps difficult to assess by mere histology. Immunostaining with PCNA, a protein correlated with cell proliferation, has been used to study tissue behavior in 30 cases of premalignant laryngeal vocal chord lesions treated by epithelial stripping in microlaryngoscopy, 15 of whom had no progression and 15 had recurrence and final development of full malignancy. The results showed a statistically significantly higher PCNA-index in the cases which underwent further tumour progression towards malignancy. PCNA testing may thus be suggested as a marker for tumour progression potential and help in determining clinical treatment choices
PCNA--a cell proliferation marker in vocal cord cancer. Part II: Recurrence in malignant laryngeal lesions
No full textLaryngeal squamous cell carcinoma constitutes the most frequent carcinoma found in the head and neck region. A precise prediction for recurrence potential cannot be done on site, treatment and histologic grading. Since Proliferating Cell Nuclear Antigen (PCNA) and DNA-cytometry have shown a good correlation between premalignant lesions and their progressive potential towards full-fledged carcinoma in the larynx as described in part I of this work, we have analyzed the PCNA index and DNA cytometry in specimen taken from vocal chord carcinomas with a 5-year follow-up, in order to assess its relationship with the presence or absence of tumour progression. 42 cases with (21) and without (21) recurrence have been examined. The DNA-index ranged from 1.01 to 1.43 (mean 1.10) in the group without and from 1.02 to 1.59 (mean 1.38) in the group with recurrent carcinoma (p = 0.002). The PCNA-index ranged from 0.00% to 18.90% (mean 6.97%) in the non-recurrent group and from 0.00 to 3g.50% (mean 16.35%) in the patients with recurrence (p = 0.001). Both indices also correlated in a highly significant way. From these data emerges a highly significant correlation between the cytometric indices of cell proliferation and PCNA immunostaining. Furthermore the high correlation between PCNA and DNA-index is of special interest for single case assessment. High DNA aberration and PCNA-index in vocal chord carcinoma may indicate a higher cellular aggressiveness of the tumour, resulting in a greater overall risk of metastases and local recurrences. Our results support the thesis that the indices of cellular proliferation within some cancers can define subsets of patients of high risk and help in isolating a population in which a more aggressive clinical protocol may be proposed
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Intranasal cocaine and lidocaine are equally effective on nitroglycerin-induced pain in cluster headache
No full textAppropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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