339 research outputs found
Dissociative excitation transfer in the reaction of O-2(a(1)Delta(g)) with OH-(H2O)(1,2) clusters.
No full textRate constants for the dissociation of OH-(H2O) and OH-(H2O)(2) by transfer of electronic energy from O-2(a(1)Delta(g)) were measured. Values of 1.8x10(-11) and 2.2x10(-11) cm(3) molecule(-1) s(-1), respectively, at 300 K were derived and temperature dependences were obtained from 300 to 500 K for OH-(H2O) and from 300 to 400 K for OH-(H2O)(2). Dissociative excitation transfer with OH-(H2O) is slightly endothermic and the reaction appears to have a positive temperature dependence, but barely outside the uncertainty range. In contrast, the reaction of OH-(H2O)(2) is exothermic and appears to have a negative temperature dependence. The rate constants are analyzed in terms of unimolecular rate theory, which suggests that the dissociation is prompt and is not affected by collisions with the helium buffer gas
Mode of action of human β-defensin 3 (hBD3) against Staphylococcus aureus and transcriptional analysis of responses to defensin challenge
No full textHuman β-defensin 3 (hBD3) is a highly charged (+11) cationic defence peptide, which retains activity against staphylococci even at elevated salt concentrations. We studied the antibiotic mode of action of hBD3 against Staphylococcus aureus SG511, using whole-cell assays and analysing the transcriptional response to hBD3 treatment. hBD3 caused rapid killing and simultaneously blocked all biosynthetic pathways, however, significant depolarisation was not observed and permeabilisation of the membrane was incomplete. The transcriptional response pattern was in part similar to those of strongly cationic amphiphiles, e.g. in that anaerobic energy production was downregulated. Significantly, part of the staphylococcal cell wall stress stimulon were upregulated. The most prominent microbial counterstrategy appears to be based on the upregulation of ABC transporters possibly functioning in detoxification of the membrane environment; the transporter genes were highly upregulated in both, a short-term response and a long-term adaptation experiment. Knockout of the most highly induced transporter VraDE significantly enhanced hBD3 susceptibility. We propose that the antibiotic activity of hBD3 is based on interference with the organisation over space and time of membrane-bound multienzyme machineries such as the electron transport chain and, in particular, the cell wall biosynthesis complex rather than on formation of defined transmembrane pores. © 2008 Elsevier GmbH. All rights reserved
Die Hallig, oder, Die Schiffbrüchigen auf dem Eiland in der Nordsee [microform] : Novelle /
No full textFilmed with: Studenten-Beichten / Otto Julius Bierbaum -- Studenten-Beichten / Otto Julius Bierbaum -- Aus dem Irrgarten der Liebe / Otto Julius Bierbaum -- Brüder / Hans Friedrich Blunck -- Zwei Spiele / Richard Billinger -- Geschichten vom Reich / Werner Beumelburg -- Lieder aus Norwegen / Max Brewer -- Das verlorene Vaterland / Walter Bloem -- Dreiklang des Krieges / Walter Bloem -- Keuschheitslegende / Rudolf G. Binding -- Feurio! / Bernhard Blume -- Rosse, Rauhnacht / Richard Billinger -- Die Jägerin / Hans Friedrich Blunck -- Gesicht und Maske / Ilse Weiss.Master Negative No. 95-4371.Microfilm.Mode of access: Internet
Vier Gedichte von Otto Julius Bierbaum für eine Singstimme mit Klavierbegleitung komponiert von Henry Hadley, op. 42. Nr.3.
No full text3 p. 33 c
Augst, Clifford G. (Death, 1898-03-16)
No full textAddress: 1414 Walnut St.Age at death: 6mo. 14da.279/Pg 29/1898/M W S/City/Dr. F.H. Bierbaum/Dusterberg/Carthage Rd.Original record filed in drawer labeled 'AUG-BACHMANN'
Proceedings coping with climate change : national summit , May 8-10, 2007 Ann Arbor, Mi/ Edit.: Rosina M. Bierbaum; Daniel G. Brown; Jan L. McAlpine
No full textvii, 245 hal.: ill.; 28 cm
Proceedings coping with climate change : national summit , May 8-10, 2007 Ann Arbor, Mi [cd]/ Edit.: Rosina M. Bierbaum; Daniel G. Brown; Jan L. McAlpine
No full textvii, 245 hal.: ill.; 28 cm
Brumbaugh, Infnat (Death, 1908-03-09)
No full textAddress: 2010 Dunlap St.Age at death: 7 Hours209/Pg. 33/1908/M W S/B. P- City/Dr. F. H. Bierbaum/Joseph Huth/Carthage Rd. Cem.Original record filed in drawer labeled 'BROWN,G.-BRUN'
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