1,721,264 research outputs found
MOLECULAR HETEROGENEITY AND PROGNOSTIC IMPLICATIONS OF SYNCHRONOUS ADVANCED COLORECTAL NEOPLASIA
Full text linkIntroduzione e scopo. In letteratura molte ipotesi sono state formulate sull’insorgenza dei tumori sincroni del colon retto (S-CRC). Infatti, non è ancora del tutto chiaro se questo tipo di malattia sviluppa attraverso un particolare pathway molecolare legato ad una elevata suscettibilità della mucosa colica a divenire neoplastica e se a livello clinico evidenzia una prognosi peggiore. Dal momento che i tumori con instabilità dei microsatelliti (MSI) possono costituire un bias nel valutare la presenza di metilazione e l’andamento clinico dei S-CRC, abbiamo analizzato per neoplasia sincrona e per disease-specific survival (DSS), una ampia casistica di CRC caratterizzata per la mutazione di BRAF e per lo stato dei microsatelliti. Pazienti e Metodi. Nello studio sono stati arruolati 881 pazienti consecutivi, i quali sono stati sottoposti a resezione del cancro del colon e hanno eseguito a livello perioperatorio una colonscopia completa. Per ogni paziente, i dati demografici e clinico-patologici sono stati recuperati e il DSS è stato valutato in modo retrospettivo. Tutti i tumori sono stati sottoposti a screening per MSI, per identificare pazienti con HNPCC, mediante l’analisi di marcatori mononucleotidici come BAT 26 e BAT25. Nei tumori con instabilità dei microsatelliti, il difetto proteico è stato individuato mediante immunoistochimica (IHC) e successivamente sono stati testati per la mutazione germinale del gene corrispondente. Inoltre, tutti i tumori sono stati anche analizzati per la mutazione di BRAF c.1799T> A. Risultati. Il S-CRC è stato associato con lo stadio IV (p = 0.01) e con l’HNPCC (p A era associata con gli MSI CRC sporadici (p A (HR 2.16, 95% CI 1.25-3.73, p = 0.01) risultano essere variabili predittori di un aumentato rischio di morte indipendenti dallo stadio di malattia. Conclusioni. I MSS S-CRC evidenziano una prognosi peggiore, e lo stesso vale per la presenza di un sincrono adenoma avanzato. Dallo studio emerge che né la presenza di multiple avanzate neoplasie in tumori MSS né la loro maggiore aggressività sono mediati da un effetto epigenetico. Per cui la sorveglianza e i protocolli terapeutici per i pazienti con un MSS CRC dovrebbero tener conto del peso prognostico dato dalla presenza di neoplasie sincrone avanzate del colon-retto.Background and Aim. It is uncertain whether synchronous colorectal cancers (S-CRC) develop through a preferential carcinogenetic pathway and whether they have a poorer prognosis. Since microsatellite unstable tumors (MSI) might act as a bias when assessing methylation and outcome of S-CRC, we analysed for synchronous neoplasia and for disease-specific survival (DSS) a large series of CRC systematically characterized by BRAF and MS status.
Patients and Methods. 881 patients consecutively resected for CRC and perioperatively investigated with complete colonoscopy, were included in the study. For each patient, demographic and clinico-pathological records were retrieved and DSS was retrospectively assessed. All cancers were screened for MSI by BAT 26/BAT25 mononucleotide analysis. MSI tumors had the MMR protein defect identified at immunohistochemistry (IHC) and were tested for germline mutation of the corresponding gene. All tumors were also analysed for BRAF c.1799T>A mutation.
Results. S-CRC was associated with stage IV (p=0.01) and with HNPCC (pA mutation (HR 2.16; 95%CI 1.25-3.73; p=0.01) were stage-independent predictors of death related to MSS CRC.
Conclusions. Microsatellite-stable CRC have a worse prognosis if S-CRC, or even a synchronous advanced adenoma, is diagnosed. Neither the occurrence of multiple MSS advanced neoplasia nor their enhanced aggressiveness are mediated by an epigenetic field effect. Surveillance and therapeutic protocols for MSS CRC should take into account the prognostic burden of synchronous advanced colorectal neoplasms
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Utilita' della fibrobroncoscopia in eta' pediatrica
No full textViene riferita la esperienza degli autori nell'uso del broncoscopio flessibile in età pediatrica
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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