1,721,036 research outputs found
Long-term treatment with cinacalcet and conventional therapy reduces parathyroid hyperplasia in severe secondary hyperparathyroidism
No full textAbstract
Background. The effect of cinacalcet on the structural
pattern of hyperplastic parathyroid glands was evaluated,
using high-resolution colour Doppler (CD) sonography,
in haemodialysis patients with severe, inadequately controlled,
secondary hyperparathyroidism (sHPT).
Methods. Nine patients (6 males, 3 females; mean age
± SD, 55.5 ± 12.6 years) received cinacalcet, with adaptation
of existing concomitant therapies. Biochemical parameters
and the morphology and vascular pattern of hyperplastic
parathyroid glands were measured at baseline and
every 6 months thereafter, for a follow-up period of 24–30
months.
Results. At baseline, 28 hyperplastic glands were identified.
Cinacalcet led to a reduction in glandular volume
during the course of the study: 68% in glands with a baseline
volume <500 mm3 and 54% in glands with a baseline
volume ≥500 mm3. The mean volume ± SD of glands
<500 mm3 changed significantly from the baseline (233 ± 115 mm3) to the end of follow-up (102 ± 132 mm3, P = 0.007). Levels of mean serum phosphorus, calcium and
calcium–phosphorus product decreased, but not significantly,
whereas there were significant decreases in mean
parathyroid hormone ± SD levels (1196 ± 381 pg/ml versus
256±160 pg/ml; P<0.0001) and alkaline phosphatase
± SD levels (428 ± 294 versus 223 ± 88 IU/l; P = 0.04),
accompanied by an improvement in a subjective clinical
score.
Conclusions. Cinacalcet, in combination with conventional
treatments, led to an improvement in biochemical and clinical
parameters of sHPT and reduced glandular volume in
patients with severe sHPT. Volume reduction was more evident
in smaller glands. Longer term, larger, randomized
clinical trials are needed to confirm these preliminary findings
and to further define a more systematic approach in
the treatment of sHPT
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Metabolic and nutritional abnormalities in kidney disease. Proceedings of the Scientific Meeting of the European Study Group for the Conservative Management of Chronic Renal Failure. Trieste, Italy, September 5-7, 1991.
No full textUso di sostanze e composizioni di natura polimerica per il trattamento dell'uremia tramite il controllo di fattori tossici e/o dipsogenici e dell'equilibrio idricosalino
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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