1,720,960 research outputs found
Novel nano-composite multi-layered biomaterial for the treatment of multifocal degenerative cartilage lesions
Full text linkWe report on a 46-year-old athletic patient, previously treated with anterior cruciate ligament reconstruction, with large degenerative chondral lesions of the medial femoral condyle, trochlea and patella, which was successfully treated with a closing-wedge high tibial osteotomy and the implant of a newly developed biomimetic nanostructured osteochondral bioactive scaffold. After 1 year of follow-up the patient was pain-free, had full knee range of motion, and had returned to his pre-operation level of athletic activity. MRI evaluation at 6 months showed that the implant gave a hyaline-like signal as well as a good restoration of the articular surface, with minimal subchondral bone oedema. Subchondral oedema was almost non-visible at 12 month
Maioregen
No full textL’obiettivo del nostro studio pilota, era di testare la validità e le performance del recente scaffold sviluppato a tre gradienti (collagene tipo I ed idrossiapatite), nanostrutturato e biomimetico. Lo studio preclinico in vivo da noi precedentemente condotto in conformità con le norme vigenti italiane ed europee, ha evidenziato buoni risultati in termini di ricostruzione dei relativi strati di tessuto cartilagineo ed osseo. Abbiamo osservato gli stessi risultati sia con l’utilizzo di scaffold caricati di condrociti autologhi sia con l’utilizzo dei soli scaffold senza cellule. Gli scaffold hanno rivelato la loro capacità di stimolare la rigenerazione “in situ” di tessuto, utilizzando le cellule staminali provenienti dal midollo osseo. Nella pratica clinica abbiamo utilizzato lo scaffold cell-free. Sono stati reclutati 30 pazienti (9 femmine e 21 maschi con età media di 29,3 anni) fra gennaio 2007 e luglio 2007. Presentavano difetti osteocondrali compresa fra i 2cm2 ed i 6cm2. Tutti i pazienti sono stati valutati con IKDC score (oggettivo e soggettivo) e Tegner score, ad un follow-up minimo di un anno. Tutti gli scores hanno evidenziato un miglioramento ad 1 anno. E’ stato notato come i peggiori risultati sono stati evidenziati nei pazienti che avevano una chirurgia pregressa, mentre non sono state osservate variazioni notevoli in coloro che hanno fatto una chirurgia associata. Abbiamo avuto un fallimento, dove è stato notato che lo scaffold non si era integrato, ed il paziente è stato rioperato. I risultati di questa tecnica chirurgica “open” e “one-step” evidenzia risultati promettenti ed incoraggianti
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Bioingegneria tissutale nella riparazione delle lesioni osteocondrali
No full textIl trattamento dei difetti condrali estesi, rappresenta un problema rilevante nella pratica ortopedica. Promettenti risultati sono stati ottenuti grazie all’ausilio dell’ingegneria tissutale ed al giorno d’oggi il trapianto di condrociti di seconda generazione (matrix-assisted) è ampiamente utilizzato in Europa. I risultati ottenuti per il trattamento delle lesioni cartilaginee sono però ancora oggetto di discussione. Inoltre, il trattamento di lesioni osteocondrali presenta problematiche di ancor più difficile soluzione coinvolgendo due tessuti con caratteristiche biologiche differenti e le tecniche attualmente più utilizzate come il trapianto autologo (mosaicoplastica) od il trapianto omologo presentano alcuni limiti. L'ingegneria tissutale possiede le potenzialità per superare tali problematiche. Gli innesti 3-D bioingegnerizzati possono essere ottenuti coltivando le cellule del paziente su scaffold composti da biomateriali porosi, che rappresentano il substrato per lo sviluppo del tessuto. Gli impianti osteocondrali bioingegnerizzati permettono in questo modo di evitare la morbosità del sito donatore e possono essere adattati facilmente alle dimensioni ed alla posizione del difetto. Inoltre, l’approccio con l’ingegneria tissutale consente di adattare le caratteristiche biologiche e biomeccaniche dell’impianto alla specifica articolazione da trattare in modo da indurre una riparazione biologica e quindi durevole nel tempo.The treatment of large chindral articular defects represents a relevant problem in orthopaedic practic
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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