3,204 research outputs found

    Grotza: étymologies possibles

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    M. G. Cossu (éd.), I limoni sono verdi di speranza. Scritti in memoria di Antonio Cossu [Mélanges en mémoire d'Antonio Cossu], Cagliari, Condaghes: 413-419Mélanges d'article

    Fusion of bone marrow-derived stem cells with striated muscle may not be sufficient to activate muscle genes

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    Several studies have demonstrated the existence of pluripotent bone marrow– derived stem cells capable of homing to injured cardiac and skeletal muscle; however, there has been little evidence demonstrating the induction of tissue-specific endogenous genes in donor stem cells following engraftment. A new study in this issue reports an intriguing finding that raises additional concerns relating to stem cell plasticity and stem cell therapy in an already heated and controversial field. The study demonstrates that wild-type bone marrow–derived side population stem cells are indeed readily incorporated into both skeletal and cardiac muscle when transplanted into mice that lack δ-sarcoglycan — a model of cardiomyopathy and muscular dystrophy. However, these cells fail to express sarcoglycan and thus to repair the tissue, which suggests that this stem cell population has limited potential for cardiac and skeletal muscle regeneration (see the related article beginning on page 1577)

    Recent achievements on underwater optical wireless communication [Invited]

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    The growing number of underwater activities is giving momentum to the development of new technologies, such as buoys, remotely operated vehicles, and autonomous underwater vehicles. The data collected by these vehicles need to be transmitted to a high-speed central unit. Clearly, wired solutions are not suitable, since they strongly impact the mobility. In this scenario, a promising solution is offered by underwater optical wireless communication (UOWC) technology, which can achieve both high-speed and wireless operation. Here, we provide a comprehensive survey on the challenges, the experimental realizations, and the state of the art in UOWC researches

    New therapies for muscular dystrophy: cautious optimism.

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    The quest for a therapy for muscular dystrophy has been the driving force behind the past 40 years of advances in this field. Numerous results, such as the identification of satellite cells and gene mutations that are responsible for most forms of dystrophies, advances in gene transfer and modification technology and, more recently, stem cells, have fueled hopes. However, administering corticosteroids still remains the only effective treatment available. Several recent advances have uncovered a diversity of possible therapeutic approaches, from pharmacological treatments to gene therapy (exon-skipping and adeno-associated viruses) and cell therapy with different types of newly identified stem cells. Importantly, a combination of these strategies might greatly enhance the possibility of successful therapy
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