198 research outputs found
Anhydramnios, intrauterine growth restriction and Echinacea angustifolia intake: a case report
No full textA preterm newborn developed anhydramnios and intrauterine growth restriction after maternal Echinacea angustifolia intake during pregnancy. A 34-year-old primigravida woman was admitted to the hospital for an emergency caesarean delivery at 35 weeks' gestation due to anhydramnios and intrauterine growth restriction. Maternal laboratory parameters were all within normal limits, while the histological examination revealed several placental infarctions. Before and during pregnancy, she was not affected by a chronic disease and had no complication or problem requiring a drug treatment. At her booking visit at 27 week gestation, clinical examination was unremarkable. Thereafter, she suffered for a fastidious common cold that she successfully treated with a product containing Echinacea angustifolia (one tablet every day for 7 weeks). The newborn (birth weight 1,330 g) did not show serious complications. On the light of a physiological pregnancy where diseases, drug treatments or other risk factors were absent, the only event that could have presumably influenced placental blood flow is a regular and prolonged maternal consumption of the herbal product containing Echinacea angustifolia, given its potential effects on foetal angiogenesis
Oxygen free radicals interact with indomethacin to cause gastrointestinal injury.
No full textIn the present study it was shown that, unlikely MK447, a known oxygen free radical compound, PGE2 is much less effective against indomethacin-induced G.I. ulcers than against ethanol damage. It seems likely that factors other than PG deficiency (such as oxygen free radicals), could be involved in the pathogenesis of NSAID-induced G.I. damage. Some compounds that can capture free radicals (aminopyrine, thiourea and its derivative, MK 447) or that inhibit the lipoxygenase pathway (MK 447, salicylazosulfapyridine, BW 755, benoxaprofen) are able to abolish indomethacin-induced G.I. damage. After irradiation with hydroxyl free radicals, indomethacin reacts with them to cause marked G.I. injury, even at a submaximal dose, one poorly ulcerogenic by itself. The above findings suggest that oxygen free radicals are one of the causal factors in the formation of NSAID-induced G.I. side effects
Comparative investigation of pharmacokinetic properties of sulbenicillin and carbenicillin in rat.
No full textComparative investigation of pharmacokinetic properties of sulbenicillin and carbenicillin in rat.
No full textDistribution of ceftazidime in ascitic fluid
No full textThe pharmacokinetics of ceftazidime were investigated in eight normal subjects and eight patients with ascites after intravenous administration of 1 g of the drug. Samples of blood and ascitic fluid were collected for 6 h after dosage, and urine samples were collected for 24 h. Pharmacokinetic data were calculated by using a one-compartment model. The apparent volume of distribution and half-life of elimination (t1/2 beta) in patients with ascites were approximately three times those in normal subjects. In contrast, renal clearance was greater in the normal subjects. With respect to ascites, the mean area under the concentration-time curve was 95.3 +/- 38.3 micrograms X h/ml. The mean ratio of the area under the concentration-time curve for ascitic fluid to that for plasma was 69.9% (+/- 38.2). These data show that ceftazidime rapidly diffuses into the peritoneal space, in which concentrations greater than 10 micrograms/ml were present for at least 6 h
In vivo and in vitro experimentation with the effects of chlorhexidine in patients who have undergone a periodontal intervention [Sperimentazione in vivo ed in vitro degli effetti della clorexidina in pazienti sottoposti ad intervento parodontale.]
No full textThe periodontal pack is often used to cover the surgical site after surgery, even when associated with local applications of preparations containing chlorexidine, in order to obtain an antiseptic protection. However many people question whether the drug effectively succeeds in penetrating the pack, or if the presence of the pack itself doesn't obstruct the action of the medication. The aim of this work is to evaluate the efficiency of the clorexidine in the surgical area with and without a periodontal pack. In a first stage, a case was chosen and contemporary operated on in two different but anatomically similar sites at the same time. One of the two sites was covered with a chlorexidine gel for the following week, whilst the other was left without medication. After seven days the stitches removed from the two different sites were placed in culture mediums to number and classify the bacterial strains present. In the second stage of the experiment, another eight patients were operated on in the same way, and the two sites covered with periodontal packs. In one of the two sites a layer of chlorexidine gel was positioned under the pack, and the chlorexidine above and on the sides of the pack was continually renewed throughout the week following the operation. The other site was not treated. The results obtained show that the pack partially reduces the action of the drug medication, probably because an insufficient amount reaches the site. The activity and efficiency of chlorexidine against the strains of bacteria found in vivo were tested in vitro. The chlorexidine destroyed all of them.(ABSTRACT TRUNCATED AT 250 WORDS
Effect of acute exercise on some haematological parameters and neutrophil functions in active and inactive subjects
No full textIn this work we studied the possible effects of acute exercise on some haematological parameters and on some functions of neutrophils in seven active and six inactive subjects. Physical exercise (10 min on a cycle ergometer at a heart rate of 150 beats.min-1) induced a significant increase in total leucocyte, lymphocyte and neutrophil concentrations in active subjects; serum iron and ferritin concentrations were lower in active compared to inactive subjects. Cellular adhesion, bactericidal activity and superoxide anion production did not change after exercise, while we also observed some differences between active and inactive subjects before exercise. In particular, the neutrophils from active subjects showed a significantly higher percentage of adhesion, higher bactericidal activity and lower superoxide anion production. In conclusion, the training induced changes in some neutrophil functions, while acute exercise influenced, overall, leucocyte concentrations
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