160,457 research outputs found

    Emerging concepts about prenatal genesis, aberrant metabolism and treatment paradigms in polycystic ovary syndrome

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    The interactive nature of the 8th Annual Meeting of the Androgen Excess and PCOS Society Annual Meeting in Munich, Germany (AEPCOS 2010) and subsequent exchanges between speakers led to emerging concepts in PCOS regarding its genesis, metabolic dysfunction, and clinical treatment of inflammation, metabolic dysfunction, anovulation and hirsutism. Transition of care in congenital adrenal hyperplasia from pediatric to adult providers emerged as a potential model for care transition involving PCOS adolescents.Selma F. Witchel, Sergio E. Recabarren, Frank González, Evanthia Diamanti-Kandarakis, Kai I. Cheang, Antoni J. Duleba, Richard S. Legro, Roy Homburg, Renato Pasquali, Rogerio A. Lobo, Christos C. Zouboulis, Fahrettin Kelestimur, Franca Fruzzetti, Walter Futterweit, Robert J. Norman, David H. Abbot

    Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: A consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society

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    Objective: Women with polycystic ovary syndrome (PCOS) often have cardiovascular disease (CVD) risk factors. The Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society created a panel to provide evidence-based reviews of studies assessing PCOS-CVD risk relationships and to develop guidelines for preventing CVD. Participants: An expert panel in PCOS and CVD reviewed literature and presented recommendations. Evidence: Only studies comparing PCOS with control patients were included. All electronic databases were searched; reviews included individual studies/databases, systematic reviews, abstracts, and expert data. Articles were excluded if other hyperandrogenic disorders were not excluded, PCOS diagnosis was unclear, controls were not described, or methodology precluded evaluation. Inclusion/exclusion criteria were confirmed by at least two reviewers and arbitrated by a third. Consensus Process: Systematic reviews of CVD risk factors were compiled and submitted for approval to the AE-PCOS Society Board. Conclusions: Women with PCOS with obesity, cigarette smoking, dyslipidemia, hypertension, impaired glucose tolerance, and subclinical vascular disease are at risk, whereas those with metabolic syndrome and/or type 2 diabetes mellitus are at high risk for CVD. Body mass index, waist circumference, serum lipid/glucose, and blood pressure determinations are recommended for all women with PCOS, as is oral glucose tolerance testing in those with obesity, advanced age, personal history of gestational diabetes, or family history of type 2 diabetes mellitus. Mood disorder assessment is suggested in all PCOS patients. Lifestyle management is recommended for primary CVD prevention, targeting low-density and non-high-density lipoprotein cholesterol and adding insulin-sensitizing and other drugs if dyslipidemia or other risk factors persist.Robert A. Wild, Enrico Carmina, Evanthia Diamanti-Kandarakis, Anuja Dokras, Hector F. Escobar-Morreale, Walter Futterweit, Rogerio Lobo, Robert J. Norman, Evelyn Talbott and Daniel A. Dumesi

    Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: An Androgen Excess Society guideline

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    Copyright © 2006 by The Endocrine SocietyObjective: The Androgen Excess Society (AES) charged a task force to review all available data and recommend an evidence-based definition for polycystic ovary syndrome (PCOS), whether already in use or not, to guide clinical diagnosis and future research. Participants: Participants included expert investigators in the field. Evidence: Based on a systematic review of the published peer-reviewed medical literature, by querying MEDLINE databases, we tried to identify studies evaluating the epidemiology or phenotypic aspects of PCOS. Consensus Process: The task force drafted the initial report, following a consensus process via electronic communication, which was then reviewed and critiqued by the AES Board of Directors. No section was finalized until all members were satisfied with the contents and minority opinions noted. Statements that were not supported by peer-reviewed evidence were not included. Conclusions: Based on the available data, it is the view of the AES Task Force on the Phenotype of PCOS that there should be acceptance of the original 1990 National Institutes of Health criteria with some modifications, taking into consideration the concerns expressed in the proceedings of the 2003 Rotterdam conference. A principal conclusion was that PCOS should be first considered a disorder of androgen excess or hyperandrogenism, although a minority considered the possibility that there may be forms of PCOS without overt evidence of hyperandrogenism but recognized that more data are required before validating this supposition. Finally, the task force recognized, and fully expects, that the definition of this syndrome will evolve over time to incorporate new research findings.Ricardo Azziz, Enrico Carmina, Didier Dewailly, Evanthia Diamanti-Kandarakis, Hector F. Escobar-Morreale, Walter Futterweit, Onno E. Janssen, Richard S. Legro, Robert J. Norman, Ann E. Taylor and Selma F. Witche

    The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report

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    ObjectiveTo review all available data and recommend a definition for polycystic ovary syndrome (PCOS) based on published peer-reviewed data, whether already in use or not, to guide clinical diagnosis and future research.DesignLiterature review and expert consensus.SettingProfessional society.PatientsNone.Intervention(s)None.Main outcome measure(s)A systematic review of the published peer-reviewed medical literature, by querying MEDLINE databases, to identify studies evaluating the epidemiology or phenotypic aspects of PCOS.Result(s)The Task Force drafted the initial report, following a consensus process via electronic communication, which was then reviewed and critiqued by the Androgen Excess and PCOS (AE-PCOS) Society AE-PCOS Board of Directors. No section was finalized until all members were satisfied with the contents, and minority opinions noted. Statements were not included that were not supported by peer-reviewed evidence.Conclusion(s)Based on the available data, it is the view of the AE-PCOS Society Task Force that PCOS should be defined by the presence of hyperandrogenism (clinical and/or biochemical), ovarian dysfunction (oligo-anovulation and/or polycystic ovaries), and the exclusion of related disorders. However, a minority considered the possibility that there may be forms of PCOS without overt evidence of hyperandrogenism, but recognized that more data are required before validating this supposition. Finally, the Task Force recognized and fully expects that the definition of this syndrome will evolve over time to incorporate new research findings.Ricardo Azziz, Enrico Carmina, Didier Dewailly, Evanthia Diamanti-Kandarakis, Héctor F. Escobar-Morreale, Walter Futterweit, Onno E. Janssen, Richard S. Legro, Robert J. Norman, Ann E. Taylor, and Selma F. Witchel (Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society

    Prof. Th. W. Adorno and the author Hans Erich Nossack.

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    Prof. Th. W. Adorno and the author Hans Erich Nossack at a reception of Insel Verlag, Buchmesse Frankfurt 1966LB

    Nowe spojrzenie na planowanie architektury mieszkaniowej w afryce subsaharyjskiej

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    The author shares his reflections on state of art in housing and urban planning, deficiencies, expectations and possibilities in the Sahel region of Africa. He notices, that the housing problem in Africa is one of the challenges, which should be solved in order to recover life dignity of African people and secure their rights to traditional family life in acceptable conditions. The paper describes the studies on the typical dispersed urban structures and the need to foster this type of settlement structure and proposals of introduction of new on light steel frame housing system in the area of Sahel, combining the traditional way of building houses with modern technology. The particularly analysed case, is the housing problem in the Republic of Chad. The author presents the basic discussion on this topic and his architectural proposals. Unfortunately, the gap between the needs and the financial feasibility of housing construction in this area, makes this project already at the starting point extremely difficult to be realized without external subventions.Problem mieszkaniowy w Afryce jest jednym z wyzwań, które należy rozwiązać, aby Afrykanie mogli odzyskać godność życiową i zabezpieczyć swoje prawa do tradycyjnego życia rodzinnego w akceptowalnych warunkach. W artykule opisano badania nad typowymi rozproszonymi strukturami miejskimi i potrzebą wspierania tego typu struktur osadniczych oraz propozycji wprowadzenia nowego systemu konstrukcji domów, opartym na lekkim szkielecie stalowym, łączącym tradycyjny sposób budowania domów z nowoczesną technologią. Przypadkiem szczególnie analizowanym jest problem mieszkaniowy w Republice Czadu. Autor przedstawia podstawową dyskusję na ten temat i swoje propozycje architektoniczne. Niestety luka między potrzebami mieszkaniowymi w Czadzie a finansową wykonalnością budownictwa mieszkaniowego w tym obszarze sprawia, że projekt ten, już w punkcie wyjścia, jest niezwykle trudny do realizacji bez uzyskania zewnętrznych dotacji

    Seeing the world anew : the radical vision of Martin Waldseemüller's 1507 & 1516 world maps /

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    9781929154470 (ISBN). 192915447X (ISBN). First edition 2012. Accompanied by 2 foldeds map in front and back pockets: 1507 map -- 1516 map.; Includes bibliographical references: pages 98-107.; Maps from pockets also available online http://nla.gov.au/nla.map-vn6254227; Original version of the 1507 map: Universalis cosmographiae secundum Ptholomaei traditionem et Americi Vespucii alioru que lustrationes. [St. Dié, France? : s.n., 1507]; Original version of the 1516 map: Carta marina, navigatoria Portugallen, navigationes atque tocius cogniti orbis terre marisque formam naturamq[u]e situs et terminos nostris temporibus recognitos et ab antiquorum traditione differentes eciam quor[um] vetusti non meminerunt auctores hec generaliter indicat / consumatum est in oppido S. Deodati compositione et digestione Martini Waldseemuller Ilacomili. [St. Dié, France? : s.n., 1516]. Prologue: In a Renaissance Vision, a Glimpse of the Modern / John W. Hessler -- "An island surrounded on all sides by sea" : The World Map, 1507 / John W. Hessler -- "Land of Cuba, part of Asia" : The Carta marina, 1516 / Chet Van Duzer -- Epilogue: A Renaissance That Resonates Still / John W. Hessler -- Notes -- Afterword / Ralph E. Ehrenberg -- About the authors -- Acknowledgments -- The Maps: The 1507 World Map, 12 sheets, with commentary -- Composite: front pocket -- The 1516 Carta marina, 13 sheets, with commentary -- Composite: back pocket

    Klimat społeczny w szkole inkluzyjnej

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    Author presented in this paper theoretical approach to the building of social climate in an inclusive school. The publication indicatessome tendencies and directions of changes to improve the functioning of these institutions and to implement the idea of inclusive education.Autorka przedstawiła w artykule teoretyczne ujęcie zagadnienia związanego z budowaniem klimatu społecznego w szkole inkluzyjnej. W publikacji ukazano pewne dążenia i kierunki zmian, jakich należy dokonywać w masowych szkołach, aby poprawić jakość funkcjonowania tych placówek, tak by kierowały się one ideą edukacji włączającej

    Ewolucja programowa FDP w polityce wschodniej w latach 1949-1969 w świetle nowych zasobów Archiwum Niemieckiego Liberalizmu

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    Zasadniczym celem artykułu jest analiza działalności programowej FDP w polityce wschodniej Republiki Federalnej Niemiec w latach 1949-1969. Autor wykorzystał nowe zasoby Archiwum Niemieckiego Liberalizmu w Gummersbach, co umożliwiło przedstawienie nowej oceny wpływu FDP na politykę wschodnią Republiki Federalnej Niemiec.The main goal of the article is to analyze the FDP's program activities in the eastern policy of the Federal Republic of Germany in the years 1949-1969. Of great importance here is the fact that the author used in this work new archives from the Archives of German Liberalism in Gummersbach. This enabled him to present a new assessment of the FDP's impact on the eastern policy of the Federal Republic of Germany

    Zasady szacowania gruntów w postępowaniach scaleniowych w Polsce

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    The subject of the study was the principles of land estimation used for the purpose of consolidation proceedings, as they are applied in Poland. The work examines the legal conditions relating to the estimation of land for the purposes of consolidation. Documents prepared in the years 2005–2017 concerning land estimation (resolutions of the consolidation participants, and protocols from the value estimates) have been collected for 41 consolidated sites, located in 28 districts of 11 voivodships (regions). A survey was conducted among the surveyors-designers of the consolidation proceedings, consisting of 19 questions. In the current year, the co-author of the present article was present at meetings of consolidation proceedings’ participants, convened in order to determine the rules for estimating land value on two sites located in different regions, and the material she collected during those meetings was used in the article. The collected data were subjected to an analysis, which showed that within Poland there is no homogeneity in the method of estimating land value for the purpose of consolidation proceedings, and that the method used to determine the value of land, taking into account the 1-hectare estimated rate, and the price of 1dt of rye grain, according to the provisions of the agricultural tax, is incompatible with the principles for the valuation of agricultural real estate, as specified in the law on real estate management.Przedmiotem badań były zasady szacowania gruntów stosowane w postępowaniach scaleniowych w Polsce. W ramach pracy przeanalizowano uwarunkowania prawne odnoszące się do szacunku gruntów na potrzeby scaleń. Zebrano dokumentację sporządzoną w latach 2005-2017 dotyczącą szacunku gruntów (uchwały uczestników scalenia i protokoły z przeprowadzonego szacunku) dla 41 obiektów scaleniowych, położonych na terenie 28 powiatów z 11 województw. Przeprowadzono ankietę wśród geodetów-projektantów scaleń, składającą się z 19 pytań. Współautorka artykułu w bieżącym roku była obecna na spotkaniach uczestników scalenia, zwołanych w celu ustalenia zasad szacowania gruntów na dwóch obiektach, zlokalizowanych w różnych województwach i zebrane materiały dotyczące tych spotkań wykorzystane zostały w artykule. Zgromadzone dane poddano analizie, która wykazała, że w Polsce nie ma jednolitości w sposobie szacowania gruntów na potrzeby postępowań scaleniowych oraz że stosowany sposób określania wartości gruntów z uwzględnieniem stawek szacunkowych 1 ha oraz ceny 1dt żyta wg przepisów o podatku rolnym jest niezgodny z zasadami wyceny nieruchomości rolnych określonymi w ustawie o gospodarce nieruchomościami
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