30 research outputs found
Gli dei romani, il Dio cristiano e Ia questione giuridica della fondazione del «popolo» nel De civitate Dei di Agostino di Ippona
No full textHost Faults Database of central Italy
No full textThe “Q-host faults database” is an original compilation, on a GIS platform, of Quaternary faults hosting the Structural Sites (SS) of the QUIN 1.0 database and neighboring to them.
It is supplementary to: QUaternary fault strain INdicators database - QUIN 1.0 - first release from the Apennines of central Italy
by: Giusy Lavecchia1,2, Simone Bello1,2*, Carlo Andrenacci1,2, Daniele Cirillo1,2, Federica Ferrarini1,2, Noemi Vicentini1,2, Rita de Nardis1,2, Gerald Roberts3, Francesco Brozzetti1,2
1: DiSPuTer - Dipartimento di Scienze Psicologiche, della Salute e del Territorio, Università G. d’Annunzio Chieti-Pescara, Chieti, Italy. 2: CRUST - Centro inteRUniversitario per l’analisi Sismotettonica Tridimensionale, Chieti, Italy. 3: Department of Earth and Planetary Sciences, Birkbeck, University of London
Corresponding author: Simone Bello ([email protected])
Climate projections of the Adriatic Sea: role of river release
No full textThe Adriatic Sea, characterized by unique local features in comparison to the broader Mediterranean Sea, stands out as a highly susceptible region to climate change. In this context, our study involves a focused climate downscaling approach, concentrating on the Adriatic water cycle. This encompasses integrated modeling at the mesoscale, covering the atmosphere, hydrology, and marine general circulation. The study period spans from 1992 to 2050, considering the high emission scenario RCP8.5. We aim at evaluating how the river release projection affects the local density stratification and the sea level rise. Indeed, the river release is found to decrease by approximately 35% in the mid-term future and condition the stratification of the water column with differences between the Northern and Southern sub-basins. The projected runoff decrease has a major impact on the Northern sub-basin, where the stratification is haline-dominated and the foreseen salinization prevails on the heating through the whole water column. Conversely, the runoff decrease has a lower impact on the Southern sub-basin, where the future changes of other mechanisms may play a major role, e.g., the changing properties of the Mediterranean water entering the Otranto Strait and the foreseen heating prevails on the salinization from the intermediate to deep water column. The study provides the first evidence of how the decreasing river discharge locally reduces the density stratification, increases the dense water, and mitigates the sea level rise in the Northern Adriatic Sea, thus acting in the opposite direction to the global warming. To minimize uncertainty in coastal ocean projections around the world, it is essential that the climate downscaling integrates high-resolution hydrology and hydrodynamics models to correctly reproduce the link between surface buoyancy and stratification and the resulting dynamics
Barracca, G. (2020). "Cicerone in Tacito: analisi di un modello nel Dialogus de oratoribus". In Pasta, G. (ed.). Mantua Humanistic Studies. Volume XIII. Mantova: Universitas Studiorum. ISBN 9788833691077. 5-23
No full textThis paper proposes a discussion on the style and the Ciceronian influences on Tacitus’ Dialogus de oratoribus. The dialogue is considered an unicum in Tacitus’ literary work, due to its literary genre and its style, so far from the inconcinnitas of the more famous historical work of Historiae and Annales. The contribution, illustrating the issue of “ciceronism” through various scholars’ different points of view, aims to demonstrate how the author consciously uses the formal style and the language which are typical of the rhetorical genre. It also intends to report and discuss all the passages (words, phrases, formulas, topoi) taken and revised by Tacitus from Cicero’s works, in order to highlight similarities and differences
Una proposta di analisi performativa : intorno alle voci del compositore e del performer che svolge la propria pratica artistica come ricerca
No full textNowadays, the reflections on the relationship between analysis and music performance are objects of an open debate in musicology, artistic research and performance studies.
The approach of the performative analysis in this study aims to contribute to the challenges (which are also characteristics) of the research in arts. Its languages are projected towards the evolution of some terms, in respect of the present philosophical and aesthetical context; its methods cannot marginalize the voice of the performers and their desire to communicate and share knowledge about the performance from their own creative experience conducted as artistic research.
By respecting the authenticity of all the roles, the goal is to bring out the voices (and all the related challenges) that occur in the production of a score and its analysis as a spatial-temporal-sound phenomenon: the composer, who is the creator, and the performer, who is the co-creator. The voice of the performer, in particular, comes out as a scholar-researcher when the aim implies both the creation of a music performance (the proper language of the art) and the creation of knowledge (the verbal meta-language) through a method based on a phenomenological observation.
This work is the result of a collaboration between three musicians, the composer, Carla Rebora, the pianist Alessandra Ammara, and the author of this article, pianist and artist-researcher
La sfida della coproduzione per i contratti di fiume nelle aree interne, guardando da sud. : Riflessioni a margine di un processo di ricerca-azione in Sicilia
No full textNella cornice del dibattito sulla coproduzione, intesa come caratteristica immanente di una pianificazione spaziale strategica mirante a innescare processi trasformativi, lo scritto si interroga su difficoltà e limiti emersi nell'ambito di una partnership di ricerca-azione di lungo termine, che ha condotto alla sperimentazione di un contratto di fiume in un'area interna Siciliana: il Patto di Fiume Simeto. Rileggendo, con sguardo critico, alcune fasi del processo, l'autrice, sulla base del proprio coinvolgimento diretto in esso, si sofferma su alcune sfide aperte dall'approccio co-produttivo in un contesto di area vasta, come una Valle fluviale: questioni di scala, di governance e coordinamento con altri strumenti di programmazione nell'ambito della politica di coesione italiana. In conclusione, lo scritto apre una riflessione sull'importanza del praticare agonismo nella pianificazione co-produttiva, come opportunità per rinsaldare le relazioni tra società civile e istituzioni pubbliche.Within the debate on coproduction, framed as an immanent characteristic of strategic spatial planning aimed at enhancing transformative processes, the paper questions the difficulties and limits that emerged from a long-term action-research partnership leading to the experimentation of the Simeto River Agreement, a river contract in an inner area of Sicily. By discussing some phases of the process through a critical lens, the author, based on her direct engagement in it, reflects on the challenges associated with the co-productive approach experienced in a river valley: issues of scale, governance and coordination with other strategic programmes within the Italian territorial cohesion policy. Finally, the paper calls for a reflection on agonism in co-productive planning, as a way of strengthening the relationship between civil society and public institutions
Targeted and untargeted proteomic approaches to disclose small molecules interactome
No full text2021 - 2022The identification of natural products and synthetic compounds target proteins is pivotal to
understand their mechanism of action for the development of molecular probes and/or potential drugs.
Functional proteomics is a mass spectrometry-based discipline focused on the analysis of the
interactome of small molecules and their targets discovery. Functional proteomics has become an
invaluable tool in targets identification of small molecules since Fishing for Partners strategy, also
named affinity purification mass spectrometry coupled approach (AP-MS), successfully disclosed a
multitude of bioactive compounds interacting proteins in the past 15 years (Rix and Superti-Furga,
2009).
Unfortunately, this strategy is not universally applicable being limited by the need of a covalent
modification of the molecular probe that should contain at least one reactive chemical group and,
most importantly, the compound modification should not influence its original bioactivity. Thus, an
alternative functional proteomics platform, based on a combination of untargeted Drug Affinity
Responsive Target Stability (DARTS) with targeted Limited Proteolysis coupled to Multiple
Reaction Monitoring (t-LiP-MRM), has been exploited during my PhD project to disclose and
characterize the interacting proteins of bioactive compounds (Lomenick et al., 2009; Feng et al.,
2014).
At first, DARTS has been exploited to identify small molecules most reliable cellular partners, then
t-LiP-MRM has been carried out to investigate the molecules/target proteins interaction features.
Moreover, the proteomics results were validated by Western Blotting to confirm small molecules
interaction with their DARTS-identified targets and by in silico molecular docking to corroborate t-
LiP-MRM information about the target region(s) involved in the binding. For an in-deep analysis of
the binding between the investigated compounds and their protein counterparts and for moving
through the activity of such compounds on their putative targets, proper in vitro and/or in cell
biological assays were also employed.
In particular, during this PhD project, MS-based proteomics approaches have been exploited to profile
the interactomes of two natural compounds (Artemetin and Tatridin A), abundant in the extracts from
Achillea millefolium (De Souza et al., 2011) and from Anthemis melanolepis (Saroglou et al., 2010),
respectively, and a synthetic benzodiazepine derivative, called 1g (Parenti et.al., 2016). The
interactomes of Artemetin, 1g and Tatridin A in HeLa, U87MG and THP-1 cells proteome have been
examined unveiling, respectively, the Filamin A and Filamin B (crucial role in the organization of
the cytoskeleton interacting with F-actin) (Zhou et al., 2021; Xu et al., 2017), the Brain Glycogen
Phosphorylase (crucial role in the degradation of the glycogen clusters in the brain and in the
regulation of the cellular glucose concentrations) (Mathieu et al., 2017) and the Phosphoglycerate
Kinase 1 (crucial role in glycolysis) (Zieker et al., 2010) as their principal cellular interactors. [edited by Author]XXX
Lithosphere tectonic context of the carbonatite-melilitite rocks of Italy
No full textABSTRACT. -The occurrence in Italy of Quaternary carbonatite-melilitite rocks, belonging to the Intra-mountain Ultra-alkaline Province (IUP), is considered in order to discuss a likely geodynamic environment for the Tyrrhenian-Apennine system. The IUP tectonic setting is described at the crustal and lithospheric scale and compared with the HK-series of the Roman eo-magmatic Province. It is concluded that a suitable mantle source for the IUP and HKS melts products (e.g. a radiogenic source with a phlogopite-bearing carbonate peridotite composition) does not need either the westward subduction of the Adriatic continental lithosphere or a mantle plume. The IUP and HKS geochemistry, as well as the deformation history of the Tyrrhenian-Apennine system, is explained in the frame of a substantially passive intra-continental rift context. The peculiar metasomatism and high radiogenic content of the HKS and IUP mantle source is attributed to fluids directly deriving from the lower mantle. RIASSUNTO.-L'inquadramento geodinamico del sistema Mar Tirreno-Appenini e stato riconsiderato alia luce della recente scoperta in Italia di una serie di rocce carbonatitico-melilititiche di eta quatemaria appartenenti alia Provincia Ultra-alcalina Intramontana (IUP). Il contesto tettonico di IUP, e delle contigue serie alte in potassio (HKS) della Provincia Comagmatica Romana (RCP), e stato esaminato sia alla scala crostale sia a quella litosferica. Le sorgenti dei magmi IUP e HKS sono rappresentate da una peridotite radiogenica a flogopite e carbonato. L'ipotesi di un arricchimento isotopico della sorgente per azione di fluidi *Corresponding author, E-mail: [email protected] provenienti da uno slab in subduzione e insufficiente, in quanto la posizione di alcuni centri (es. area del Vulture) non e compatibile con quella di un possibile piano di subduzione ovest immergente; inoltre, non e necessaria, in quanto valori isotopici di Sr e Nd, simili a quelli delle rocce italiane, sono stati riscontrati in altre aree geodinamiche in distensione o intra-continentali. Si puo escludere anche l'attivita di un plume astenosferico, poiche non si osservano i fenomeni tipici di questo tipo di ambiente (doming crostale, elevate temperature astenosferiche, attivita magmatica che predata quella tettonica, forti valori di assottigliamento litosferico contro bassi valori di estensione litosferica). La geochimica delle rocce IUP ed HKS e 1' evoluzione geodinamica del sistema Tirreno-Appennini puo essere, invece, ben inquadrata in un contesto di rift passivo intra continentrale, che ha determinato forti estensioni litosferiche con conseguente sollevamento di una astenosfera arricchita in fluidi metasomatici e radiogenici. Questi fluidi potrebbero essere direttamente risaliti dal boundary layer localizza to ad una profondita di circa 670 km, al limite tra mantello superiore ed inferiore
