1,721,107 research outputs found
Solidarietà, o delle sorti della democrazia. Libertà ed eguaglianza nel pensiero politico di Pierre Leroux (1830 – 1871).
No full textQual è il portato politico della solidarietà? In che modo essa può contribuire al consolidamento e alla tenuta della democrazia? In un momento nel quale il ruolo della solidarietà è sfidato e svilito dal prevalere di una visione economicistica e fortemente individualistica della vita in comune, il volume ricostruisce il cruciale ruolo politico che le assegna un autore ancora relativamente poco studiato quale Pierre Leroux. In un contesto caratterizzato dalla progressiva diffusione del capitalismo, dalla nascita del movimento operaio e dal drammatico manifestarsi della questione sociale, egli individua nella solidarietà il principio in grado di consentire la conciliazione tra la costituzione repubblicana garante delle libertà civili e un assetto sociale ispirato al principio dell'eguaglianza. Proponendo una riflessione originale e ancora rilevante per il contesto attuale, Leroux mostra come la solidarietà, fornendo sostanza al formalismo repubblicano e opponendo resistenza a qualunque progetto organicistico e totalizzante, permetta di arginare i rischi per la democrazia posti tanto dall’individualismo assoluto, quanto dal socialismo assoluto, favorendo l’instaurazione di una repubblica democratica e sociale nella quale i problemi lasciati aperti dalla modernità sono suscettibili di trovare risposta e la triade repubblicana Liberté, Égalité, Fraternité può finalmente trovare compimento
Influence of protein net charge on the nucleic acid helix-destabilizing activity of various pancreatic ribonucleases
No full textIn vitro synthesis of pig pancreas ribonuclease.
No full textFrom studies on the in vitro synthesis of the heavily glycosylated pig pancreas ribonuclease (molecular weight of the protein moiety is 13 786, on the basis of the amino acid composition), the following points emerge: (1) the enzyme is synthesized as a precursor having an apparent molecular weight about 7000 higher than that of the mature non-glycosylated protein; (2) the mRNA coding for the enzyme protein consists of about 950 nucleotides
Small-Fiber Neuropathy: An Etiology-Oriented Review
Full text linkBackground: Small-fiber neuropathy (SFN), affecting Aδ or C nerve fibers, is characterized by alterations of pain and temperature sensation, as well as autonomic dysfunction. Its diagnosis may still remain challenging as methods specifically assessing small nerve fibers are not always readily available, and standard techniques for large-fiber neuropathies, such as electroneuromyography, yield negative results. Still, skin biopsy for epidermal innervation and quantitative sensory testing allow for diagnosis in the presence of a congruent clinical picture. Objectives: Many different etiologies may underlie small-fiber neuropathy, of which metabolic (diabetes mellitus/impaired glucose tolerance) and idiopathic remain prevalent. The aim of this narrative review is to provide a general picture of SFN while focusing on the different etiologies described in the literature in order to raise awareness of the variegated set of different causes of SFN and promote adequate diagnostic investigation. Methods: The term “Small-Fiber Neuropathy” was searched on the PubMed database with its different recognized etiologies: the abstracts of the articles were reviewed and described in the article if relevant for a total of 40 studies. Results: Many different disorders have been associated with SFN, even though often in the form of case reports or small case series. Conclusions: Idiopathic forms of SFN remain the most prevalent in the literature, but association with different disorders (e.g., infectious, autoimmune) should prompt investigation for SFN in the presence of a congruent clinical picture (e.g., pain with neuropathic features)
Influence of protein net charge on the nucleic acid helix-destabilizing activity of various pancreatic ribonucleases
No full textRepression of the IL-6 gene is associated with hypermethylation
No full textThe expression of the IL-6 gene is usually tightly controlled and may be induced in specific tissues after treatment with appropriate stimuli. Although much is known about the inducible expression of the IL-6 gene, the molecular mechanisms responsible for its repression in specific tissues or cell types remain poorly defined. To address this question we have studied two human breast carcinoma cell lines, MDA-MB-231, in which the IL-6 gene is expressed, and, MCF-7, in which the IL-6 message is undetectable by Northern blot assay even in the presence of inducers. The expression of the IL-6 message was estimated after treatment with 5-aza-2'deoxycytidine and the methylation state of the IL-6 gene was analyzed. We show herein that treatment of MCF-7 cells with an agent which reduces DNA methylation correlates with IL-6 gene hypomethylation and increases the level of its expression
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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