163 research outputs found
“The media will always have axes to grind but the police have the capacity to project their side of the story better” – Neeraj Kumar
No full textNeeraj Kumar recently retired as the Commissioner of Police Delhi, having served in the Indian Police Service for over 37 years in a wide range of roles. He has now penned his first book, a collection of stories pertaining to high-profile cases solved during his nine year tenure at the Central Bureau of Investigation. Ahead of the London launch of the book, he spoke to Sonali Campion about the IPS, security and corruption in India. Dial D for Don: Inside stories of CBI missions will be launched at the Nehru Centre on 13 July at 6.30pm. The event is free and open to all and will include a panel with leading journalist Owen Bennett Jones and the author. Details here
Synthesis, Characterization, Cytotoxicity Analysis and Evaluation of Novel Heterocyclic Derivatives of Benzamidine against Periodontal Disease Triggering Bacteria
No full textPeriodontal disease (PD) is multifactorial oral disease that damages tooth-supporting tissue. PD treatment includes proper oral hygiene, deep cleaning, antibiotics therapy, and surgery. Despite the availability of basic treatments, some of these are rendered undesirable in PD treatment due to side effects and expense. Therefore, the aim of the present study is to develop novel molecules to combat the PD triggering pathogens. The study involved the synthesis of 4-((5-(substituted-phenyl)-1,3,4-oxadiazol-2-yl)methoxy)benzamidine (5a-e), by condensation of 2-(4-carbamimidoylphenoxy)acetohydrazide (3) with different aromatic acids; and synthesis of 4-((4-(substituted benzylideneamino)-4H-1,2,4-triazol-3-yl)methoxy)benzamidine (6a-b) by treatment of compound 3 with CS2 followed by hydrazination and a Schiff reaction with different aromatic aldehydes. Synthesized compounds were characterized based on the NMR, FTIR, and mass spectrometric data. To assess the effectiveness of the newly synthesized compound in PD, new compounds were subjected to antimicrobial evaluation against P. gingivalis and E. coli using the micro-broth dilution method. Synthesized compounds were also subjected to cytotoxicity evaluation against HEK-293 cells using an MTT assay. The present study revealed the successful synthesis of heterocyclic derivatives of benzamidine with significant inhibitory potential against P. gingivalis and E. coli. Synthesized compounds exhibited minimal to the absence of cytotoxicity. Significant antimicrobial potential and least/no cytotoxicity of new heterocyclic analogs of benzamidine against PD-triggering bacteria supports their potential application in PD treatment
Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides
No full textIn this study a series ofnew1-(2-aryl-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanones 2a-e was synthesized by the cyclization of imines 1a-e using acetic anhydride. The products were evaluated for anti-bacterial and anti-fungal activity. Among the newly synthesized compounds, 1-(2-(4-(dimethylamino)phenyl)-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2a)and1-(2-(4-chlorophenyl)-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanone (2b)were found to possess maximum activity against the tested strains of S. aureus and P. aeruginosa. It was concluded that para-substitution enhances the activity of synthesized oxadiazoles
Enhanced thermoelectric power factor of Cu2ZnSnS4 in the presence of Cu2-xS and SnS2 secondary phase
No full textFunctionalization and migration of bromine adatoms on zigzag graphene nanoribbons: A first-principles study
No full textSynthesis, Characterization and Biological Evaluation of Novel Benzamidine Derivatives: Newer Antibiotics for Periodontitis Treatment
No full textPeriodontal disease (PD) is complex polymicrobial disease which destroys tooth-supporting tissue. Although various synthetic inhibitors of periodontitis-triggering pathogens have been recognized, their undesirable side effects limit their application. Hence, the present study intended to perform the synthesis, characterization, antimicrobial evaluation, and cytotoxicity analysis of novel benzamidine analogues (NBA). This study involved the synthesis of novel imino bases of benzamidine (4a–c), by reacting different aromatic aldehydes with 2-(4-carbamimidoylphenoxy) acetohydrazide (3), which was synthesized by the hydrazination of ethyl 2-(4-carbamimidoylphenoxy) acetate (2), the derivative of 4-hydroxybenzene carboximidamide (1). This was followed by characterization using FTIR, 1H, 13C NMR and mass spectrometry. All synthesized compounds were further tested for antimicrobial potential against PD-triggering pathogens by the micro broth dilution method. The cytotoxicity analysis of the NBA against HEK 293 cells was conducted using an MTT assay. The present study resulted in a successful synthesis of NBA and elucidated their structures. The synthesized NBA exhibited significant antimicrobial activity values between 31.25 and 125 µg/mL against tested pathogens. All NBA exhibited weak cytotoxicity against HEK 293 cells at 7.81 µg, equally to chlorhexidine at 0.2%. The significant antimicrobial activity of NBA against PD-triggering pathogens supports their potential application in periodontitis treatment
Synthesis, molecular docking and anti-inflammatory potential of novel hydrazones of eugenol in tuberculosis treatment
No full text551-558The hydrazone derivatives of eugenol have been designed and synthesized via esterification, hydrazination and treatment
with different aldehydes or ketones. All these compounds have been docked with 4COX and 3LN1 (COX-2 enzymes) using
Schrodinger v7.4. The compounds have been characterized by IR, 1H NMR and LCMS. The compounds have been
evaluated for their anti-inflammatory potential using in vivo carrageenan induced rat hind paw method and in vitro protein
denaturation. The study reveals that most compounds have significant anti-inflammatory activity. Tested compounds as per
literature prove that they show antitubercular activity. Among tested compounds, compounds 4, 34, 37 and 42 exhibit the
highest anti-inflammatory activity. The present study shows that anti-inflammatory activity of the novel hydrazone
derivatives of eugenol is strongly connected with the position of the substituent on aromatic aldehyde or ketone. As these
compounds possess both the activities, therefore they may be useful in tuberculosis treatment
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