198,145 research outputs found
Alheimer (548 m) bei Rotenburh a. Fulda
No full textALHEIMER (548 M) BEI ROTENBURH A. FULDA
Alheimer (548 m) bei Rotenburh a. Fulda ( -
Job: Digitalisierung Stiftsarchiv Fulda
No full textIm Hessischen Staatsarchiv Marburg sind zum nächstmöglichen Zeitpunkt für 27 Monate eineinhalb Stellen – alternativ: drei Teilzeitstellen – für Wissenschaftliche Angestellte (m/w; BAT IIa) in dem DFG Projekt „Online-Edition des Stiftsarchivs der Reichsabtei Fulda“ zu besetzen. Das Staatsarchiv Marburg verwahrt umfangreiche und wertvolle Urkundenbestände (insgesamt ca. 122.000 Urkunden). Darunter befindet sich das Stiftsarchiv der Reichsabtei Fulda mit 2400 Urkunden für die Zeit 751-1837. Durc..
How to target apoptosis signaling pathways for the treatment of pediatric cancers
No full textApoptosis represents one of the most important forms of cell death in higher organisms and is typically dysregulated in human cancers, including pediatric tumors. This implies that ineffective engagement of cell death programs can contribute to tumor formation as well as tumor progression. In addition, the majority of cytotoxic therapeutic principles rely on the activation of cell death signaling pathways in cancer cells. Blockade of signaling networks that lead to cell death can therefore confer treatment resistance. A variety of genetic and epigenetic events as well as dysfunctional regulation of signaling networks have been identified as underlying causes of cell death resistance in childhood malignancies. Apoptosis pathways can be therapeutically exploited by enhancing proapoptotic signals or by neutralizing antiapoptotic programs. The challenge in the coming years will be to successfully transfer this knowledge into the development of innovative treatment approaches for children with cancer
Replication files for "Planning until death do us part"
No full textThese are the replication files for the following publication: Fulda, Barbara E. & Lersch, Philipp M. (forthcoming): Planning Until Death Do Us Part: Partnership Status and Financial Planning Horizon. Journal of Marriage and Family. doi: 10.1111/jomf.124
Replication files for "Planning until death do us part"
No full textThese are the replication files for the following publication: Fulda, Barbara E. & Lersch, Philipp M. (forthcoming): Planning Until Death Do Us Part: Partnership Status and Financial Planning Horizon. Journal of Marriage and Family. doi: 10.1111/jomf.124
The combined role of long chain acyl-CoA synthetase 2, long chain acyl-CoA synthetase 4 and long chain acyl-CoA synthetase 9 in lipid metabolism of Arabidopsis
No full textThe combined role of long chain acyl-CoA synthetase 2, long chain acyl-CoA synthetase 4 and long chain acyl-CoA synthetase 9 in lipid metabolism of Arabidopsis
No full textRegulation of cell death in cancer - possible implications for immunotherapy
No full textSince most anticancer therapies including immunotherapy trigger programmed cell death in cancer cells, defective cell death programs can lead to treatment resistance and tumor immune escape. Therefore, evasion of programmed cell death may provide one possible explanation as to why cancer immunotherapy has so far only shown modest clinical benefits for children with cancer. A better understanding of the molecular mechanisms that regulate sensitivity and resistance to programmed cell death is expected to open new perspectives for the development of novel experimental treatment strategies to enhance the efficacy of cancer immunotherapy in the future
Aerndtfest-Predigt zu Otterwisch am XV. Sonnt. nach Trin. 1784. : Dem Andenken der Hochfürstl. Vermählung in dieser Kirche
No full textvon M. Joh. Julius Christian Fulda, Pfarrer zu Otterwisch und Stockheim in Grimm. Diöcös.Autopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Leipzig, gedruckt mit Breitkopfischen Schriften, 1784
Shifting the balance of mitochondrial apoptosis: therapeutic perspectives
No full textSignaling via the intrinsic (mitochondrial) pathway of apoptosis represents one of the critical signal transduction cascades that control the regulation of cell death. This pathway is typically altered in human cancers, thereby providing a suitable target for therapeutic intervention. Members of the Bcl-2 family of proteins as well as cell survival signaling cascades such as the PI3K/Akt/mTOR pathway are involved in the regulation of mitochondria-mediated apoptosis. Therefore, further insights into the molecular mechanisms that form the basis for the control of mitochondria-mediated apoptosis will likely open new perspectives to bypass evasion of apoptosis and treatment resistance in human cancers
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