2,682 research outputs found
Natural Variation of the Circadian Clock in Neurospora
No full textMost living organisms on earth experience daily and expected changes from the rotation of the earth. For an organism, the ability to predict and prepare for incoming stresses or resources is a very important skill for survival. This cellular process of measuring daily time of the day is collectively called the circadian clock. Because of its fundamental role in survival in nature, there is a great interest in studying the natural variation of the circadian clock. However, characterizing the genetic and molecular mechanisms underlying natural variation of circadian clocks remains a challenging task. In this chapter, we will summarize the progress in studying natural variation of the circadian clock in the successful eukaryotic model Neurospora, which led to discovering many design principles of the molecular mechanisms of the eukaryotic circadian clock. Despite the success of the system in revealing the molecular mechanisms of the circadian clock, Neurospora has not been utilized to extensively study natural variation. We will review the challenges that hindered the natural variation studies in Neurospora, and how they were overcome. We will also review the advantages of Neurospora for natural variation studies. Since Neurospora is the model fungal species for circadian study, it represents over 5 million species of fungi on earth. These fungi play important roles in ecosystems on earth, and as such Neurospora could serve as an important model for understanding the ecological role of natural variation in fungal circadian clocks.Advances in Genetics, Vol. 99
Corrigendum to “A generic multi-level framework for microscopic traffic simulation with automated vehicles in mixed traffic” [Transport. Res. Part C: Emerg. Technol. 110 (2020) 291–311] (Transportation Research Part C (2020) 110 (291–311), (S0968090X19304322), (10.1016/j.trc.2019.11.019))
No full textThe authors regret that a contributing author was missing from the list of authors. The complete list of authors should be: “S.C. Calvert, B. van Arem, & J. W. C. van Lint”. All are with Delft University of Technology, Department of Transport & Planning, The Netherlands updated as above. The authors would like to apologise for any inconvenience caused.Transport and Plannin
Towards the Holy Grail: combining system dynamics and discrete-event simulation in healthcare
No full textThe idea of combining discrete-event simulation and system dynamics has been a topic of debate in theoperations research community for over a decade. Many authors have considered the potential benefits ofsuch an approach from a methodological or practical standpoint. However, despite numerous examples ofmodels with both discrete and continuous parameters in the computer science and engineering literature,nobody in the OR field has yet succeeded in developing a genuinely hybrid approach which truly integratesthe philosophical approach and technical merits of both DES and SD in a single model. In this paperwe consider some of the reasons for this and describe two practical healthcare examples of combinedDES/SD models, which nevertheless fall short of the “holy grail” which has been so widely discussed inthe literature over the past decade
Hybrid simulation for health and social care: the way forward, or more trouble than it’s worth?
No full textDeconvolution of the Co\u3csub\u3e3\u3c/sub\u3eO\u3csub\u3e4\u3c/sub\u3e(110) Fuchs–Kliewer phonon spectrum
No full textThe Fuchs–Kliewer phonon spectrum of single crystal Co3O4(110) has been treated with a Fourier transform log deconvolution method, which removes multiple scattering features from the single loss spectrum. Auger electron spectroscopy (AES), x-ray photoelectron spectroscopy (XPS) and low-energy electron diffraction (LEED) were first used to characterize the Co3O4 crystal establishing the cleanliness, composition, and order of the (110) surface. High resolution electron energy loss spectroscopy (HREELS) was then used to obtain the phonon spectrum for an incident electron energy of 3.77 eV. Due to the strong dipole cross section for the Fuchs–Kliewer phonon modes, intense multiple electron scattering was detected, which provided a complicated and overlapping combination of all possible loss modes. Deconvolution removed the multiple loss modes to produce well-resolved Fuchs–Kliewer fundamental phonon losses at 218, 373, 598, and 682 cm-1 (27.0, 46.2, 74.1, and 84.6 meV). These values are compared to the fundamental loss energies obtained by resolving the overlapping peak structure with standard peak fitting procedures, which confirmed the single loss energies obtained with the deconvolution procedure. Deconvolution results from the four fundamental phonon spectrum of single crystal Co3O4(110) were also compared to those from the simpler spectra of CoO(100) and thin-film CoO(100)–Co3O4 epitaxy and some practical aspects of the deconvolution process discussed in this context
Waste and innovation. How waste companies and government can interact to stimulate innovation in the Dutch waste industry
No full textThis thesis answers the question how government and Dutch waste companies can interact in such a way that innovation is stimulated. The author has developed a method to determine the potential for self-regulation and self-control of a company or an industry. This method is based upon the measurement of degree to which the company has assured legal compliance within the own organisation. Furthermore an approach is given to create innovation-friendly regulation using innovation theoretical principles.Industrial Design Engineerin
Policy analysis of water management for the Netherlands. Vol VII: Assessment of impacts on drinking-water companies and their customers
No full textThis volume assesses the impacts of a number of water management policies developed by PAWN on drinking-water (DW) companies and their customers (households, commercial entities, and industrial firms). Chapter 2 summarizes briefly the major water-related problems facing DW companies in the Netherlands today, and shows why the author believes they will become more severe in the future. Chapter 3 describes the methodology in detail. Chapter 4 presents the impacts and associated discussion of PAWN's primary and groundwater cases on DW production, and on DW companies and their customers. Finally, in Chap. 5, the author assesses those impacts, draws some overall conclusions, and discusses the implications of those conclusions for the future supply and costs of DW in the Netherlands.PAW
Author Correction:A 41,500 year-old decorated ivory pendant from Stajnia Cave (Poland)
No full textCorrection to: Scientific Reports https://doi.org/10.1038/s41598-021-01221-6, published online 25 November 2021The original version of this Article contained errors in the author list where Marjolein D. Bosch was omitted from the author list, and Mikołaj Urbanowski was incorrectly listed as an author of the original Article, and has subsequently been removed.The Author contributions section now reads:“S.T. W.N. and A.N. conceived the project; S.T., W.N., A.P., M.B., S.C., M.D., H.F., A.M., M.D. B., D.P., M.P.R., C.M.R., V.S-M., G.M.S., P.S., M.S., K.S., A.V., F.W., H.W., A.W., M.Z., S.B., A.N., J-J. H., performed research; S.T., A.P., W.N., M.B., M.D.B., S.C., M.D., H.F., A.M., D.P., M.P.R., C.M.R., V.S-M., G.M.S., P.S., M.S., K.S., A.V., F.W., H.W., A.W., M.Z., S.B., A.N., J-J. H. analysed all archaeological data; S.T. and A.P. wrote the paper with the collaboration of all the co-authors.”The original Article and its accompanying Supplementary Information file have been corrected
Opkomende technologie met impact
No full textAutomatische voertuigen bieden grote kansen op het gebiedvan toegankelijkheid, mobiliteit en verkeersveiligheid, als wede risico’s op tijd onder ogen zien, zegt Simeon Calvert.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Transport and Plannin
Friends of the Library Guest Lecture: Author S.C. Gwynne
No full textCampus EventsNew York Times bestselling author S. C. Gwynne discusses his books "Rebel Yell: The Violence, Passion, and Redemption of Stonewall Jackson" and "Empire of the Summer Moon: Quanah Parker and the Rise and Fall of the Comanches" in a two part lecture.Angelo State UniversityFriends of the Porter Henderson Library and West Texas CollectionASU History Departmen
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