2,767 research outputs found
GAME PREVIEW: GS Heads to Texas State For Thursday Night Fun
No full textGAME PREVIEW: GS Heads to Texas State For Thursday Night Fu
EBUS-GS and VBN for GGO lesions
No full textBackground: Endobronchial ultrasonography with guide sheath (EBUS-GS) could be useful for diagnosing ground-glass opacity (GGO) predominant-type lesions in the peripheral lung. Furthermore, several studies have reported that transbronchial biopsy using EBUS-GS and virtual bronchoscopic navigation (VBN) was safe and effective for diagnosing small peripheral lung lesions. Our objectives were to diagnose solitary peripheral GGO predominant-type lesions by transbronchial biopsy using EBUS-GS and VBN under radiographic fluoroscopic guidance, and to evaluate the clinical factors associated with diagnostic yield. Methods: The medical records of 169 patients with GGO predominant-type lesions who underwent transbronchial biopsy using EBUS-GS and VBN under radiographic fluoroscopic guidance were retrospectively reviewed. Results: Endobronchial ultrasonography images could be obtained for 156 (92%) of 169 GGO predominant-type lesions, and 116 (69%) were successfully diagnosed by this method (20 of 31 pure GGO lesions [65%]; 96 of 138 mixed GGO predominant-type lesions [70%]). The mean size of diagnosed lesions was significantly larger than that of nondiagnosed lesions (22 mm versus 18 mm, p < 0.01). Regarding diagnostic yield based on computed tomography sign, cases with presence of a bronchus leading directly to a lesion had significantly higher diagnostic yield than the other lesions (p < 0.01). Conclusions: The addition of VBN to EBUS-GS could be useful in clinical practice for diagnosing GGO predominant-type lesions in the peripheral lung
Global sourcing strategy and structure: Toward an integrated conceptual framework
No full textPurpose - The purpose of this paper is to develop a synthesised conceptual framework for global sourcing (GS) strategy and structure.
Design/methodology/approach – We adopt a systematic literature review method and analyse through content analysis techniques 52 peer-reviewed journal articles focused on global sourcing strategy and structure. Based on these analyses, a conceptual model is developed.
Findings - A synthesised construct of GS strategy, consisting of three dimensions, i.e., supply internationalisation, internal integration and external integration, is proposed. The GS structure construct is further broken down into structural design and control and coordination, consisting of three dimensions for each. Propositions for GS strategy, GS structure and, in particular, the relationships between them are developed for future empirical validation.
Originality/value - This is the first study which synthesises various dimensions of GS strategy and GS structure and advances/extends the theory of the strategy-structure nexus to a GS context. The conceptual model provides a comprehensive framework for future empirical work and opens avenues of research on this topic
Turning Maneuver Prediction of Connected Vehicles at Signalized Intersections: A Dictionary Learning-Based Approach
No full textVehicle-to-Infrastructure (V2I) communication has provided a solution for the improvement of the traffic efficiency of smart city intersections. For example, turning maneuvers prediction at signalized intersections in a connected environment helps traffic command centers time traffic lights and dynamically predict traffic flow. However, the modeling methods used in existing research on this topic have some limitations, such as poor scalability and interpretability of machine learning. Thus, this study proposes a dictionary learning-based approach to predict turning maneuvers before the intersection. The proposed dictionary model estimates the LogDet divergence-based sparse inverse covariance matrix (LDbSICM) of driving behavior samples. The graphical lasso method is used to estimate the sparse inverse covariance matrix of the driving samples to construct a dictionary library of the maneuver behavior. The LogDet divergence is used to calculate the difference between each inverse covariance matrix. A driving simulator is utilized to collect experimental data consisting of turning left (TL), turning right (TR), and going straight (GS) behaviors to establish and evaluate the proposed model. The experimental results demonstrate that the proposed dictionary learning-based turning maneuver prediction model achieves 100% prediction accuracy for TL and GS and 97.2% for TR. The proposed model has substantial advantages over existing methods. The model can predict TL, TR, and GS in a connected environment 270, 280, and 290 m, respectively, before the intersection. Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Transport and Plannin
Global sourcing strategy and structure: Toward an integrated conceptual framework
No full textThe strategy-structure nexus has been a mainstream topic in management research. While an increasing number of studies have deepened this issue in general P&SM and in GS context, research is still developing and unified constructs are lacking. Building on a review of GS literature and adapting constructs from organizational theory, we develop a conceptual model of GS strategy and structure. Within the model, a GS strategy construct is advanced, based on three dimensions: supply internationalization, internal integration and external integration. The GS structure construct is broken down into structural design and control/coordination, consisting of three dimensions for each. Some propositions for GS strategy, structure and their relationships are developed
IKEA: Global sourcing and sustainable leather initiatives
No full textAims: the aim of this teaching case is to illustrate the Sustainable Global Sourcing (SGS) practices of IKEA influenced by its Global Sourcing (GS) strategy and structure aspects through a case study of the sustainable leather initiative.Scope: this study is developed though 20 face-to-face interviews with IKEA managers in both Sweden and China, covering all the major SGS-related departments i.e. purchasing,sustainability, IWAY, and competence center (sustainable project team).Contribution: we provide a benchmark of SGS for other multinational companies and allows for a thorough discussion of a sustainability initiative in a GS context. The case can be used to teach graduate/postgraduate in agricultural economics, MBA and executive students on sustainable supply chain management and corporate social responsibility.<br/
Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon
No full textN Ashwanikumar,1,* Nisha Asok Kumar,2,* S Asha Nair,2 GS Vinod Kumar11Chemical Biology, 2Cancer Research Programme, Rajiv Gandhi Center for Biotechnology, Poojappura, Thiruvananthapuram, Kerala, India *These authors contributed equally to this workAbstract: Methacrylic-based copolymers in drug-delivery systems demonstrate a pH-sensitive drug-releasing behavior in the colon. In this study, copolymers of methacrylic acid and 2-ethyl hexyl acrylate were prepared using a microemulsion polymerization technique. The purified copolymer was characterized by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and differential scanning calorimetry. 5-Fluorouracil (5-FU) was entrapped within methacrylic-based copolymers by a solvent evaporation method. The size of the nanogels formed was characterized by transmission electron microscopy and atomic force microscopy. In vitro drug-release studies using phosphate-buffered saline at different pH levels demonstrated the sustained release of 5-FU and its pH dependence. Cell proliferation assay of a human colon tumor colon cancer cell line (HCT-116) was performed and showed that the nanogels containing 5-FU exhibited considerable cytotoxicity in comparison with free 5-FU. Cell uptake of the nanogels was also monitored using confocal microscopy. Western blot analysis and flow cytometry studies confirmed that the nanogels could be successfully used as an efficient vector for pH-sensitive and controlled delivery of drugs specifically targeted to the colon.Keywords: 5-FU, methacrylic polymer, colon cancer, nanoge
Effect of transmembrane Ca2+ gradient on Gs function
No full textAbstractGs and adenylate cyclase from bovine brain cortices were co-reconstituted into asolectin liposomes with or without 1000-fold transmembrane Ca2+ gradient. Obtained results showed that Gs activities of both binding GTPγS and stimulating adenylate cyclase were the highest in proteoliposomes, with a transmembrane Ca2+ gradient similar to the physiological situation and the lowest while the transmembrane Ca2+ gradient was in the inverse direction. Such a difference could be diminished following the dissipation of the transmembrane Ca2+ gradient by A23187. Time-resolved fluorescence anisotropy of diphenylhexatriene (DPH) has been used to compare the physical state of phospholipids among those proteoliposomes. It is suggested that a proper transmembrane Ca2+ gradient is essential for higher membrane fluidity, which may favor Gs function with higher GTP-binding activity and stimulation of adenylate cyclase
Rigorous results on the strongly correlated electron systems by the spin-reflection-positivity method
No full textIn this talk, we shall briefly review some results on the strongly correlated electron systems, derived recently by applying Lieb's spin-reflection-positivity method. To explain the basic ideas of this method to a wide audience, we emphasize the important role played by Marshall's rule in studying the many-body systems.Physics, AppliedPhysics, Condensed MatterPhysics, MathematicalSCI(E)CPCI-S(ISTP)
Antiferromagnetic correlation in the half-filled strongly correlated electron models at nonzero temperature: A rigorous result
No full textAs an extension of our previous rigorous investigation on the spin correlations in the ground states of the half-filled Hubbard model and the periodic Anderson model [G. S. Tian, Phys. Rev. B 50, 6246 (1994)], in the present paper we study the behavior of these correlation functions at finite temperature. We show rigorously that, at any T not equal0, the predominant spin correlations in these systems are antiferromagnetic. Furthermore, based on this result, we also show that a quasi-one (or two)-dimensional itinerant electron ferrimagnet must have a gapless branch of ferromagnetic excitations. This conclusion is consistent with the previous results derived by the spin-wave theory.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000169283000058&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Physics, Condensed MatterSCI(E)10ARTICLE22null6
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