41,231 research outputs found
1993-1994 T. R. Pearson
No full textT. R. Pearson, a.k.a. Rick Gavin, was born in Winston-Salem, North Carolina. He was a student at North Carolina State University, where he gained a B.A. and M.A. in English. He was the first recipient of the John and Renée Grisham Writer in Residence Fellowship. He is the acclaimed author of fourteen novels, including A Short History of a Small Place and Warwolf, and a dozen screenplays. Top of the Rock is his fifth nonfiction book. He lives in Virginia and Brooklyn, New York. (Photo credit: Marian Young)https://egrove.olemiss.edu/grisham_res/1026/thumbnail.jp
Correction to: female reproductive organs of Brassica napus are more sensitive than male to transient heat stress
No full textThe article Female reproductive organs of Brassica napus are more sensitive than male to transient heat stress, written by Sheng Chen, Renu Saradadevi, Miriam S. Vidotti, Roberto Fritsche-Neto, Jose Crossa, Kadambot H. M. Siddique, Wallace A. Cowling, was originally published Online First without Open Access. After publication in volume 217: 117 the author decided to opt for Open Choice and to make the article an Open Access publication. Therefore, the copyright of the article has been changed t
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Letter from J. R. Eakin to Carl Hayden
No full textLetter from J. R. Eakin to Carl T. Hayden concerning access to Rowe Well and the canyon
Letter from J. R. Eakin to Stephen Mather
No full textLetter from J. R. Eakin to Stephen T. Mather about expenses and reconstruction of the Kaibab Trail
Letter from Carl Hayden to J. R. Eakin
No full textLetter from Carl T. Hayden to J. R. Eakin regarding changes to the Grand Canyon National Park boundaries and the purchase of lands from William Randolph Hearst
Letter from F. R. Goodman to Carl Hayden
No full textLetter from F. R. Goodman to Carl T. Hayden asking for clarification about the agreement to construct an approach road to the par
Letter from Carl Hayden to F. R. Goodman
No full textLetter from Carl T. Hayden to F. R. Goodman concerning the purchase of Bright Angel Trail and construction of an approach road to the park
Slc11a1 limits intracellular growth of Salmonella enterica sv. Typhimurium by promoting macrophage immune effector functions and impairing bacterial iron acquisition
No full textThe natural resistance-associated macrophage protein 1, Slc11a1, is a phagolysosomal transporter for protons and divalent ions including iron that confers host protection against diverse intracellular pathogens including Salmonella. We investigated and compared the regulation of iron homeostasis and immune function in RAW264.7 murine phagocytes stably transfected with non-functional Slc11a1 and functional Slc11a1 controls in response to an infection with Salmonella enterica serovar Typhimurium. We report that macrophages lacking functional Slc11a1 displayed an increased expression of transferrin receptor 1, resulting in enhanced acquisition of transferrin-bound iron. In contrast, cellular iron release mediated via ferroportin 1 was significantly lower in Salmonella-infected Slc11a1-negative macrophages in comparison with phagocytes bearing Slc11a1. Lack of Slc11a1 led to intracellular persistence of S.?enterica serovar Typhimurium within macrophages, which was paralleled by a reduced formation of nitric oxide, tumour necrosis factor-alpha and interleukin-6 in Slc11a1-negative macrophages following Salmonella infection, whereas interleukin-10 production was increased. Moreover, Slc11a1-negative phagocytes exhibited higher cellular iron content, resulting in increased iron acquisition by intracellular Salmonella. Our observations indicate a bifunctional role for Slc11a1 within phagocytes. Slc11a restricts iron availability, which first augments pro-inflammatory macrophage effector functions and second concomitantly limits microbial iron access. <br/
R-boundedness of smooth operator-valued functions
No full textIn this paper we study -boundedness of operator families \mathcal{T}\subset \calL(X,Y), where and are Banach spaces. Under cotype and type assumptions on and we give sufficient conditions for -boundedness. In the first part we show that certain integral operator are -bounded. This will be used to obtain -boundedness in the case that is the range of an operator-valued function T:\R^d\to \calL(X,Y) which is in a certain Besov space B^{d/r}_{r,1}(\R^d;\calL(X,Y)). The results will be applied to obtain -boundedness of semigroups and evolution families, and to obtain sufficient conditions for existence of solutions for stochastic Cauchy problems.Electrical Engineering, Mathematics and Computer Scienc
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