100,789 research outputs found
Myositis ossificans
No full textDefinition: Myositis ossificans is a self-limiting benign lesion that can arise in any type of soft tissue most frequently in muscle as a solitary lesion. It consists of a process in which soft tissues are interested by mature lamellar bone formation in association with inflammation mostly caused by traumatic or neurological injury surgery burns or other diseases
Fibromatosis (all types)
No full textFibromatosis consists in a wide group of benign mesenchymal proliferation. In WHO 2013 it belongs to the group of fibroblastic/miofibroblastic neoplasms not metastasizing but with a potential locally aggressive behavior. They can arise either from fasciae (superficial type) or from deep tissue
Corrigendum to “SELNET clinical practice guidelines for bone sarcoma” Critical reviews in oncology/hematology, vol. 174 (2022), 1–10 (Critical Reviews in Oncology / Hematology (2022) 174, (S1040842822001093), (10.1016/j.critrevonc.2022.103685))
No full textThe authors regret, the “IRCCS Istituto Ortopedico Rizzoli, University of Bologna, Via Pupilli, 1, 40136 Bologna, Italy” related author affiliations reported in the article is not correct; therefore, we kindly ask you to forward a request for rectification. E Palmerini 2, D M Donati2, T Frisoni 2, A Righi 2, K Scotlandi2. 2 - IRCCS Istituto Ortopedico Rizzoli, Via Pupilli, 1, 40136, Bologna, Italy. The authors would like to apologise for any inconvenience caused
Cognitive impairment modulates the effect of depressive symptoms on mortality in elderly people
No full textLetter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Resting state cortical electroencephalographic rhythms in covert hepatic encephalopathy and Alzheimer's disease
No full textPatients suffering from prodromal (i.e., amnestic mild cognitive impairment, aMCI) and overt Alzheimer's disease (AD) show abnormal cortical sources of resting state electroencephalographic (EEG) rhythms. Here we tested the hypothesis that these sources show extensive abnormalities in liver cirrhosis (LC) patients with a cognitive impairment due to covert and diffuse hepatic encephalopathy (CHE). EEG activity was recorded in 64 LC (including 21 CHE), 21 aMCI, 21 AD, and 21 cognitively intact (Nold) subjects. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). EEG cortical sources were estimated by LORETA. Widespread sources of theta (all but frontal), alpha 1 (all but occipital), and alpha 2 (parietal, temporal) rhythms were higher in amplitude in all LC patients than in the Nold subjects. In these LC patients, the activity of central, parietal, and temporal theta sources correlated negatively, and parietal and temporal alpha 2 sources correlated positively with an index of global cognitive status. Finally, widespread theta (all but frontal) and alpha 1 (all but occipital) sources showed higher activity in the sub-group of LC patients with CHE than in the patients with aMCI or AD. These results unveiled the larger spatial-frequency abnormalities of the resting state EEG sources in the CHE compared to the AD condition
Impact of corrosion products on the IFMIF Lithium loop activation induced by neutrons: inventories, gamma decay sources and dose rate estimations
No full textThe Report presents a first assessment of the impact of corrosion products produced in IFMIF lithium loop from the perspective of worker doses. Activation of the impurities contained in liquid lithium occurs during the passage through the target both due to irradiation of neutrons and of the deuteron beam. Only the impact due to neutron activation, produced in the d+Li interactions, has been considered in this Report. Contact dose rates, as a measure of the biological potential hazard of the total decay gamma-ray source, as a direct contact, of the activated material, have been evaluated via the ANITA-IEAF activation code package. The dose rates due to the transport of decay gamma rays on the surfaces and at 50 cm, 1m and 5m of main lithium loop components, Longest Pipe, Heat Exchanger and Quench Tank, have been estimated at shutdown and at different cooling times. These calculations were performed via the deterministic Vitenea-IEF/SCALENEA-1 shielding sequence and MCNP-4C2 code, as a check.
Main conclusions of these first calculations are:
- the worker radiation protection could be a concern for IFMIF if a good purification system of Li will not continuously run,
- all Li loop area have to be declared “Restricted Access Zone” and,
- specific procedures and worker protection equipments (such as Remote Handling tools) and shielding have to be considered to maintain the Li loop.
Future work have to be dedicated to perform further parametric evaluations varying main input data, such as corrosion rates and irradiation scenarios, and to evaluate effects of deuteron beam
FDG-PET/CT Guided Biopsy in Angiosarcoma of Bone: Diagnosis, Staging and Beyond.
No full textPrimary angiosarcoma of the bone (PAB) is a particularly rare and aggressive form of malignancy in the spectrum of vascular tumours, and it accounts for less than 1% of sarcomas. This case of PAB, diagnosed thanks to FDG-PET/CT guided biopsy, is a paradigm of how powerful are clinical informations that can be derived by a F-FDG PET/CT, in view of negative or inconclusive imaging of conventional radiology, starting from the metabolic characterization of an equivocal finding, the possibility to drive the biopsy towards the most active site, the accurate total body staging, the stratification of prognosis and early therapy assessmen
The accomplishment of the Engineering Design Activities of IFMIF/EVEDA: The European-Japanese project towards a Li(d,xn) fusion relevant neutron source
No full textThe International Fusion Materials Irradiation Facility (IFMIF), presently in its Engineering Validation and Engineering Design Activities (EVEDA) phase under the frame of the Broader Approach Agreement between Europe and Japan, accomplished in summer 2013, on schedule, its EDA phase with the release of the engineering design report of the IFMIF plant, which is here described. Many improvements of the design from former phases are implemented, particularly a reduction of beam losses and operational costs thanks to the superconducting accelerator concept, the re-location of the quench tank outside the test cell (TC) with a reduction of tritium inventory and a simplification on its replacement in case of failure, the separation of the irradiation modules from the shielding block gaining irradiation flexibility and enhancement of the remote handling equipment reliability and cost reduction, and the water cooling of the liner and biological shielding of the TC, enhancing the efficiency and economy of the related sub-systems. In addition, the maintenance strategy has been modified to allow a shorter yearly stop of the irradiation operations and a more careful management of the irradiated samples. The design of the IFMIF plant is intimately linked with the EVA phase carried out since the entry into force of IFMIF/EVEDA in June 2007. These last activities and their on-going accomplishment have been thoroughly described elsewhere (Knaster J et al [19]), which, combined with the present paper, allows a clear understanding of the maturity of the European-Japanese international efforts. This released IFMIF Intermediate Engineering Design Report (IIEDR), which could be complemented if required concurrently with the outcome of the on-going EVA, will allow decision making on its construction and/or serve as the basis for the definition of the next step, aligned with the evolving needs of our fusion community. © 2015 IAEA, Vienna
Computer assisted surgery and 3d printing in orthopaedic oncology: A lesson learned by cranio-maxillo-facial surgery
No full textPrimary bone sarcomas are rare tumors and surgical resection in combination with chemo and radiation therapy is the mainstay of treatment. Some specific anatomical sites still represent a reconstructive challenge due to their complex three-dimensional anatomy. In recent years, patient specific instruments along with 3D printing technology has come to represent innovative techniques in orthopaedic oncology. We retrospectively reviewed 23 patients affected by primary bone sarcoma treated with patient-specific instruments and 3D printing custom made prostheses. At follow up after approximately two years, the infection rate was 26%, mechanical complication rate 13%, and local recurrence rate 13% (with a five-years implant survival rate of 74%). Based on our experience, patient-specific instruments and 3D custom-made prostheses represents a reliable and safe technique for improving the accuracy of resection of primary bone tumour, with a particular use in pelvic surgery ameliorating functional results
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