519 research outputs found
Letter From Leigh Hunt to Dear Sir
No full textabstract: Concerning Hunt's request that the recipient reply with the time in which Hunt's little boy can come pick up payment for an article Hunt wrote.Seller's Description: Attached note reads: 133 Hunt, Leigh. English author, A.L.s. in the third person. 1 p., 4to; with the integral address leaf. "Regents' Park-May" n.d. $50.00.Curator's Note: Handwritten notes read "1833 or 1839" on recto and "From Men, Women, and Books" on verso.Paper details: Glue on verso indicated it was once glued into a book. Originally folded.Creation Date Details: Range given is the author's lifespan.Provenance: Removed from a set of Hunt's
Men, women, and books; a selection of sketches, essays, and critical memoirs, from his uncollected prose writings, by Leigh Hunt. Publisher London, Smith, Elder and co., 1847.
Local Call Numbers: SPEC E-1691 v.1, SPEC E-1691 v.2, SPEC E-1691 v.1,
SPEC E-1691 v.2
Letter From Leigh Hunt to Edward Moxon
No full textabstract: Concerning Hunt's agitation at Mrs. Guest's actions and appeals to Moxon and Hunt's request that Moxon show this note to Mr. Forster.Curator's Note: This letter was partially published in A Sentimental Library, Comprising Books Formerly Owned by Famous Writers, Presentation Copies, Manuscripts and Drawings written by Harry Bache Smith (1860-1936), a successful American lyricist, writer, and composer.Provenance: Most likely donated to Special Collections along with the following three books:
1) Stories from the Italian poets : with lives of the writers / by Leigh Hunt. Publisher London : Chapman and Hall, 1846.
Local Call Number: SPEC E-1906 v.1
2) Stories from the Italian poets : with lives of the writers / by Leigh Hunt. Publisher London : Chapman and Hall, 1846.
Local Call Number: SPEC E-1906 v.2
3) A sentimental library, comprising books formerly owned by famous writers, presentation copies, manuscripts, and drawings collected and described by Harry B. Smith. With fifty-six illustrations. Publisher [New York] Privately Printed [by the De Vinne press] 1914.
Local Call Number: SPEC BA-152Postage Details: Address: Mr Moxon, Bond Street. Marked "Private." Folded for mailing
Retraining displaced workers : what can developing countries learn from OECD nations?
No full textThe governments of most industrial countries provide financial support for adult training programs intended to retrain displaced workers. The author draws lessons from the experience of six industrial countries (Australia, Britain, Canada, Japan, Sweden, and the United States) on how to design and implement such retraining programs in low-income developing nations and middle-income countries. By retraining, the author means both improving job skills and remediating deficiencies in basic education. These are the lessons he emphasizes: Training programs should be independent of the educational system, with its rigid ties to degree requirements and academic schedules; links to employers must be developed and maintained so that trainees have marketable skills on completing the program. Training programs should be designed to minimize trainees'foregone earnings; basic education should be relevant to the jobs the trainees might seek. External providers of education must be made accountable - but with care; the system of accountability should also ensure that the needs of displaced workers most likely to suffer long-term unemployment are met. Not all displaced workers require relatively expansive retraining; some may need only inexpensive job-search assistance services. A permanent, institutionalized training system is preferable to short-term intervention.Labor Standards,Tertiary Education,ICT Policy and Strategies,Health Monitoring&Evaluation,Teaching and Learning
Una nueva categoría de urnas "acompañantes".. Anales del Instituto Nacional de Antropología e Historia. Num. 43 Tomo XIV (1961) Sexta Época (1939-1966)
No full textCaso, A. Las Estelas Zapotecas, Monografías del Museo Nacional de Arqueología, Historia y Etnografía. México, 1928.Caso, A. y Bernal, l. Urnas de Oaxaca. Memorias del lnstituto Nacional de Antropología e Historia. México, 1952.Leigh, H. Boletín de Estudios Oaxaqueños. Mexico City College, No. 2, marzo I, 1958 y No. 6, mayo 15. México, 1958
Title IX vs. NCAA: A Gameplan for Championship Equity
No full textIn 1972, Congress enacted Title IX of the Education Amendments Act (Title IX) to prohibit sex-based discrimination in “any education program or activity receiving federal financial assistance.” While the original legislation did not stipulate “athletics,” Title IX has had a profound impact on intercollegiate sports by expanding the athletic opportunities for women as a covered “program or activity.” However, fifty years after the enactment of Title IX, there are still significant disparities between men’s and women’s intercollegiate athletics, most notably at the high-profile National College Athletics Association (NCAA or Association) Championships.
In 2021, the NCAA hosted the men’s and women’s Division I Basketball Championship tournaments. A viral video featuring inferior weight rooms for women served as a catalyst to address longstanding gender equity issues in intercollegiate athletics. In response to the widely publicized inequities, the NCAA commissioned an independent gender equity review of all NCAA Championships. The external review confirmed gender inequities in ten women’s intercollegiate sports and raised the issue of whether the NCAA should be subject to Title IX.
Educational institutions are subject to Title IX as “recipients” of federal financial assistance, and courts have found violations when institutions fail to provide female student-athletes with equal opportunities to participate or equitable benefits and services. In contrast to its member institutions, the NCAA has avoided compliance with Title IX on the basis that the Association is not a “recipient” of federal financial assistance. In 1999, the US Supreme Court ruled in NCAA v. Smith that the NCAA’s receipt of membership dues from educational institutions did not constitute the “receipt” of federal aid. Based on this narrow ruling, the NCAA was not subject to Title IX.
The Smith decision exposed the “recipient” loophole in Title IX legislation, which has enabled the NCAA to operate above the law for decades, resulting in significant gender disparities at NCAA Championships. However, Justice Ginsburg’s decision in Smith left open an alternative legal theory to potentially bring the NCAA under the scope of Title IX. The NCAA’s “controlling authority” over federally funded educational institutions’ athletic programs could trigger Title IX coverage, irrespective of whether the NCAA itself is a “recipient” of federal aid. Analyzed within the context of NCAA Championships, where the NCAA controls the postseason intercollegiate tournaments, a court could find that the NCAA is a “controlling authority” over its member institutions and liable for gender inequities.
To the extent courts are unable to bring the NCAA under the scope of Title IX, Congress recently introduced two bills that address gender equity in intercollegiate athletics. In June 2021, Congress passed a concurrent resolution that stipulates Title IX applies to the NCAA; in August 2022, the Senate reintroduced the College Athletes Bill of Rights, which includes a Title IX section that mandates intercollegiate athletic associations shall not discriminate based on sex. While these bills do not have the full force of law, they clearly indicate Congress’ intent to prevent sex-based discrimination in intercollegiate athletics and require the NCAA to comply with Title IX.
This Article asserts that the NCAA should be covered by Title IX, and the Association should comply with the federal law’s mandate to prohibit sex-based discrimination in “any education program or activity.” To achieve gender equity at NCAA Championships, there are three pathways to bring the NCAA under Title IX coverage: the existing federal law could be interpreted to cover the NCAA, Congress could pass a new statute to cover the NCAA, or the NCAA could voluntarily comply with Title IX. This article analyzes these three alternatives and concludes that the NCAA should voluntarily comply with Title IX and uphold the Association’s stated commitment to gender equity
Blame, culture and child protection
No full textIn recent years child protection issues have dominated media and public discourse in the UK. This book offers a unique perspective by giving voice to those social workers working within a profession which has become increasingly embedded in a culture of blame. Exploring how statutory child protection agencies function, Leigh also reveals how 'organisational culture' can significantly affect the way in which social work is practised. Providing a comparative analysis between the UK and Belgium, Leigh uses ethnography to illuminate the differences between the settings by examining how interactions and affected atmospheres impact on their identities. This book reveals how practitioners perceive themselves differently in such environments and explores the impact this has on their identity as well as the work they carry out with children and families. Leigh's enquiry and compelling critique into social work, identity and organisations calls for mutual understanding and respect, rather than a culture of blame. © The Editor(s) (if applicable) and The Author(s) 2017. All rights reserved
Clinical and molecular survey in 124 Chinese patients with Leigh or Leigh-like syndrome
No full textLeigh syndrome is the most common mitochondrial disorder in children characterized by necrotic lesions in the central nervous system. Both mitochondrial DNA (mtDNA) and nuclear DNA defects in the mitochondrial respiratory chain can lead to this disease. To characterize the clinical and genetic traits of Leigh or Leigh-like syndrome patients in China, 124 unrelated cases were collected between 1992 and 2005. Seventy-seven cases (62.1%) met the typical criteria of Leigh syndrome, including symmetrical bilateral abnormal signals in the basal ganglia, thalamus and brain stem, etc. Other cases (37.9%) belonged to Leigh-like syndrome with atypical clinical or radiological manifestations. Late-onset patients accounted for 20.2%, which is more than previously reported. Movement disorder was the most common symptoms in our patients. Thirty-two patients (25.8%) were confirmed to carry mutant genes. Among them, six cases (4.8%) have been demonstrated to have point mutations in mitochondrial DNA. Two separate patients were detected to have mutations on A8344G and A3243G. The T8993G point mutation was identified in one patient and T8993C in one other patient. SURF1 mutations associated with cytochrome-c oxidase deficiency were identified in 25 patients (20.2%). Four unreported variations have been identified in SURF1 gene from three patients. G604C was found in 22 patients. Only one patient had C214T mutation in the pyruvate dehydrogenase E1alpha subunit gene. In the remaining 92 patients (74.2%), a specific molecular dysfunction or underlying metabolic abnormality could not be identified.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000245470900023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Endocrinology & MetabolismGenetics & HereditySCI(E)PubMed16EDITORIAL MATERIAL2265-2653
Pathogenic Bi-allelic Mutations in <em>NDUFAF8</em> Cause Leigh Syndrome with an Isolated Complex I Deficiency
No full text\ua9 2019 The Author(s). Leigh syndrome is one of the most common neurological phenotypes observed in pediatric mitochondrial disease presentations. It is characterized by symmetrical lesions found on neuroimaging in the basal ganglia, thalamus, and brainstem and by a loss of motor skills and delayed developmental milestones. Genetic diagnosis of Leigh syndrome is complicated on account of the vast genetic heterogeneity with >75 candidate disease-associated genes having been reported to date. Candidate genes are still emerging, being identified when “omics” tools (genomics, proteomics, and transcriptomics) are applied to manipulated cell lines and cohorts of clinically characterized individuals who lack a genetic diagnosis. NDUFAF8 is one such protein; it has been found to interact with the well-characterized complex I (CI) assembly factor NDUFAF5 in a large-scale protein-protein interaction screen. Diagnostic next-generation sequencing has identified three unrelated pediatric subjects, each with a clinical diagnosis of Leigh syndrome, who harbor bi-allelic pathogenic variants in NDUFAF8. These variants include a recurrent splicing variant that was initially overlooked due to its deep-intronic location. Subject fibroblasts were found to express a complex I deficiency, and lentiviral transduction with wild-type NDUFAF8-cDNA ameliorated both the assembly defect and the biochemical deficiency. Complexome profiling of subject fibroblasts demonstrated a complex I assembly defect, and the stalled assembly intermediates corroborate the role of NDUFAF8 in early complex I assembly. This report serves to expand the genetic heterogeneity associated with Leigh syndrome and to validate the clinical utility of orphan protein characterization. We also highlight the importance of evaluating intronic sequence when a single, definitively pathogenic variant is identified during diagnostic testing
Addressing Challenges of Planning in Multimodal Transportation Nodes with Simulation Games
No full textGlobal transportation knows many different modalities – goods arrive from far away places by ship, plane, railway, or truck. Airports and seaports both represent important nodes within the global transportation network. Both show distinct characteristics, but also similarities when it comes to challenges like required flexibility, robustness, reliability and situational awareness of the stakeholders involved. In this article, we introduce two different simulation games addressing some of these challenges in two complex transportation nodes and discuss the qualitative results of user tests with the games. Within a comparative section, we show how simulation games can be used to address the challenges of multimodal transportation.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Policy Analysi
Engineering tumor-targeted poly(amidoamine) (PAMAM) dendrimers for improved penetration and cellular delivery of short-interfering RNA (siRNA) through solid tumors
No full textCancer remains the second leading cause of death in the United States, despite significant advances in anticancer research. The standard-of-care for the treatment of cancer includes surgery in conjunction with traditional chemotherapy drugs or radiation therapy. However, the inherent cytotoxicity of conventional chemotherapeutics often causes adverse side effects in patients. Nanoscale materials have found utility for drug delivery to tumors as they accumulate in the tumor vasculature , reducing the necessary drug dose to patients. They have also proven useful to deliver unconventional drugs, including short-interfering RNA (siRNA), which is being explored to silence oncogenes. However, the current lack of safe, efficient siRNA delivery systems limits its widespread clinical use. The objective of this dissertation was to study the ability of poly(amidoamine) (PAMAM) dendrimers to facilitate the delivery of siRNA to malignant glioma on the cellular and tumor tissue levels. The intracellular delivery aspects of PAMAM-mediated siRNA delivery to malignant glioma cells were explored by employing partial surface amine acetylation of PAMAM dendrimers to reduce their net positive charge This work demonstrated the importance of endosomal buffering and the advantages of charge reduction on siRNA delivery. The ability of PAMAM dendrimers to mediate tumor-targeted siRNA delivery to tumor tissue was also studied. Dendrimers were modified to display various numbers of RGD peptides, and the number of peptides present influenced the distribution of siRNA cargo throughout a three-dimensional tumor model of malignant glioma. A biophysical analysis was performed to elucidate the transport mechanisms governing the tumoral penetration of these bioconjugates, and cellular binding affinity was found to influence significantly the transport of the bioconjugate materials through solid tumors. The results from this dissertation provide insights into the mechanisms governing siRNA delivery to cancer on both the cellular and tumor tissue levels. Design guidelines for tumor-targeted nanoscale siRNA delivery vectors were derived, and a methodology was developed to understand the mechanisms governing the penetration and transport of siRNA drugs throughout solid tumors. This work will help other researchers to design more effective drug delivery systems for anticancer applications, and it may impact the effect of siRNA and nanoscale materials on human disease.Ph. D.Includes bibliographical referencesIncludes vitaby Carolyn Leigh Wait
- …
