1,720,955 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mathematical Modeling of Cancer Cell Growth in the Presence of Cytotoxic Drugs
No full textCancer has one of the biggest impacts on our society as almost 2 million new cases will be diagnosed each year and approximately 38% of people in the US will be diagnosed with cancer at some point in their life. Cancer is the uncontrolled proliferation of cells in the body due to mutations that result in tumors. Current systems that model the growth of cancer cells by determining the IC50 are inefficient because they are time dependent and often do not consider the Emax value, leading to inconsistencies in the IC50 value obtained. The IC50 value is important in consistently giving the correct dosage of chemotherapy drugs to patients. Another common issue with chemotherapy drugs is the side effects caused by high dosages and nonspecific cellular targets. These effects can significantly impact a patient's quality of life and cause other significant health problems after the chemotherapy. The use of nanoparticles to deliver anticancer drugs to cancer cells may improve the side effects often associated with chemotherapy by targeting cancer cells with greater specificity and killing smaller amounts of noncancer cells. Carbon allotropes such as carbon nanotubes (CNTs) and nitrogen doped graphene quantum dots (NGQDs) can be linked to chemotherapy drugs to better target cancer cells because they possess qualities such as resistance to degradation, increased circulation time, and high surface area to volume ratio. Our project aims to create a new mathematical model which is time independent to provide a better, more consistent IC50 value to use in the dosage of drug. In addition, we are exploring the use of carbon nanoparticles in targeting cancer cells and their ability to decrease the amount of drug necessary therefore decreasing the IC50 of the drug, resulting in decreased chemotherapy side effects
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Immunologic and Non-Immunologic Paraneoplastic Syndromes Associated with Small Cell Lung Cancer
No full textParaneoplastic syndromes are a heterogeneous group of disorders associated with neoplasms which are caused by secretion of physiologically active substances or immune-mediated tissue damage, but not due to direct tumor growth. Most commonly these syndromes are associated with small cell lung cancer. There are many different types of paraneoplastic syndromes. Paraneoplastic syndromes can be broadly classified as non-immunologic or immunologic in mechanism. First, non-immunologic syndromes such as neuroendocrine paraneoplastic syndromes are those which involve the ectopic secretion of hormones, most commonly anti-diuretic hormone and adrenocorticotropic hormone. Next, immunologic syndromes such as paraneoplastic neurologic syndromes are considered an autoimmune mediated disease process, leading to disorders such as Lambert-Eaton Myasthenic syndrome, subacute sensory neuropathy, and limbic encephalitis. While many different cancers are associated with paraneoplastic syndromes, the most common solid tumor type associated paraneoplastic syndromes is small cell lung cancer. These syndromes, while relatively uncommon, are important to identify as they can significantly impact morbidity and mortality in patients. The diversity of paraneoplastic syndromes makes them difficult to diagnose. Awareness of the clinical presentation and diagnostic criteria of paraneoplastic syndromes can help providers better treat these patients and possibly identify malignancies at an earlier stage. This article aims to increase awareness of these syndromes and expand a provider’s differential diagnosis to help patients reach a diagnosis and improve morbidity and mortality
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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